Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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ST-Align: A Multimodal Foundation Model for Image-Gene Alignment in Spatial Transcriptomics

Spatial transcriptomics (ST) provides high-resolution pathological images and whole-transcriptomic...

Prob-cGAN: A Probabilistic Conditional Generative Adversarial Network for LSD1 Inhibitor Activity Prediction

The inhibition of Lysine-Specific Histone Demethylase 1 (LSD1) is a promising strategy for cancer ...

BioDSNN: a dual-stream neural network with hybrid biological knowledge integration for multi-gene perturbation response prediction.

Studying the outcomes of genetic perturbation based on single-cell RNA-seq data is crucial for under...

Nov 2024 39584702
Bayesian unsupervised clustering identifies clinically relevant osteosarcoma subtypes.

Identification of cancer subtypes is a critical step for developing precision medicine. Most cancer ...

Nov 2024 39701601
A review of deep learning models for the prediction of chromatin interactions with DNA and epigenomic profiles.

Advances in three-dimensional (3D) genomics have revealed the spatial characteristics of chromatin i...

Nov 2024 39708837
scRGCL: a cell type annotation method for single-cell RNA-seq data using residual graph convolutional neural network with contrastive learning.

Cell type annotation is a critical step in analyzing single-cell RNA sequencing (scRNA-seq) data. A ...

Nov 2024 39708840
KPRR: a novel machine learning approach for effectively capturing nonadditive effects in genomic prediction.

Nonadditive genetic effects pose significant challenges to traditional genomic selection methods for...

Nov 2024 39749663
RiceSNP-ABST: a deep learning approach to identify abiotic stress-associated single nucleotide polymorphisms in rice.

Given the adverse effects faced by rice due to abiotic stresses, the precise and rapid identificatio...

Nov 2024 39757606
Integrating scRNA-seq and scATAC-seq with inter-type attention heterogeneous graph neural networks.

Single-cell multi-omics techniques, which enable the simultaneous measurement of multiple modalities...

Nov 2024 39800872
Deep learning in integrating spatial transcriptomics with other modalities.

Spatial transcriptomics technologies have been extensively applied in biological research, enabling ...

Nov 2024 39800876
scGO: interpretable deep neural network for cell status annotation and disease diagnosis.

Machine learning has emerged as a transformative tool for elucidating cellular heterogeneity in sing...

Nov 2024 39820437
scHiClassifier: a deep learning framework for cell type prediction by fusing multiple feature sets from single-cell Hi-C data.

Single-cell high-throughput chromosome conformation capture (Hi-C) technology enables capturing chro...

Nov 2024 39831891
Inferring the genetic relationships between unsupervised deep learning-derived imaging phenotypes and glioblastoma through multi-omics approaches.

This study aimed to investigate the genetic association between glioblastoma (GBM) and unsupervised ...

Nov 2024 39879386
Classification-based pathway analysis using GPNet with novel P-value computation.

Pathway analysis plays a critical role in bioinformatics, enabling researchers to identify biologica...

Nov 2024 39879387
Introducing TEC-LncMir for prediction of lncRNA-miRNA interactions through deep learning of RNA sequences.

The interactions between long noncoding RNA (lncRNA) and microRNA (miRNA) play critical roles in lif...

Nov 2024 39927859
Inferring tumor purity using multi-omics data based on a uniform machine learning framework MoTP.

Existing algorithms for assessing tumor purity are limited to a single omics data, such as gene expr...

Nov 2024 39950745
DECA: harnessing interpretable transformer model for cellular deconvolution of chromatin accessibility profile.

The assay for transposase-accessible chromatin with sequencing (ATAC-seq) identifies chromatin acces...

Nov 2024 39987573
Noninvasive fetal genotyping using deep neural networks.

Circulating cell-free DNA (cfDNA) is a powerful diagnostics tool that is widely studied in the conte...

Nov 2024 39992001
Reducibility among NP-Hard graph problems and boundary classes

Many NP-hard graph problems become easy for some classes of graphs, such as coloring is easy for b...

An Evolutional Neural Network Framework for Classification of Microarray Data

DNA microarray gene-expression data has been widely used to identify cancerous gene signatures. Mi...

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