Genetics

Design of highly functional genome editors by modelling CRISPR-Cas sequences.

Gene editing has the potential to solve fundamental challenges in agriculture, biotechnology and hum...

Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.

Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of l...

CYCLONE: recycle contrastive learning for integrating single-cell gene expression data.

BACKGROUND: Combining single-cell transcriptome sequencing results from several batches reduces batc...

Refined prognostication of pathological complete response in breast cancer using radiomic features and optimized InceptionV3 with DCE-MRI.

BACKGROUND: Neoadjuvant therapy plays a pivotal role in breast cancer treatment, particularly for pa...

AI expands the repertoire of CRISPR-associated proteins for genome editing.

CRISPR-GPT for agentic automation of gene-editing experiments.

Performing effective gene-editing experiments requires a deep understanding of both the CRISPR techn...

Identification of DNA damage response and crotonylation-related biomarkers for lung adenocarcinoma via machine learning and WGCNA.

DNA damage response (DDR) and crotonylation occur frequently in lung adenocarcinoma (LUAD), but thei...

Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing.

BACKGROUND: Cholesterol metabolism plays a significant role in cancer progression, including prostat...

DGMM: A Deep Learning-Genetic Algorithm Framework for Efficient Lead Optimization in Drug Discovery.

Lead optimization in drug discovery faces the dual challenge of maintaining structural diversity whi...

A prediction model for genetic cholestatic disease in infancy using the machine learning approach.

OBJECTIVES: Cholestasis in infancy poses a complex clinical conundrum for pediatric hepatologists, w...

Oxidative Stress Links Thyroid Autoimmunity to Cancer: Peroxiredoxin 2 Protection via Genomic and Single-Cell Insights.

This study identifies shared genetic factors linking Hashimoto's thyroiditis (HT) and thyroid cance...

Integrated transcriptomic and proteomic analysis identifies FBXW7 as a key regulator of tau homeostasis in Alzheimer's disease.

BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder driven by complex, in...

Methods and applications of in vivo CRISPR screening.

A fundamental goal in genetics is to understand the connection between genotype and phenotype in hea...

Transfer learning prediction of type 2 diabetes with unpaired clinical and genetic data.

The prevalence of type 2 diabetes mellitus (T2DM) in Korea has risen in recent years, yet many cases...

Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have n...

CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma.

The tumor microenvironment (TME) of kidney renal clear cell carcinoma (KIRC) exhibits complex dynami...

Interpretable graph Kolmogorov-Arnold networks for multi-cancer classification and biomarker identification using multi-omics data.

The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge...

Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma.

Strategies to slow the aging process or mitigate its consequences on health rely on the validation o...

2OMe-LM: predicting 2'-O-methylation sites in human RNA using a pre-trained RNA language model.

MOTIVATION: 2'-O-methylation (2OMe) is a common post-transcriptional modification in RNA that plays ...

Ensemble of Bayesian alphabets via constraint weight optimization strategy improves genomic prediction accuracy.

This study proposes a weight optimization-based ensemble framework aimed at improving genomic predic...

Plasmonic Fiber Optic Sensing Platform for Point-of-Care Pharmacokinetic Monitoring of Platinum Chemotherapeutics: Toward Ultratrace Multi-omics Precision Chemotherapy Management.

Precision chemotherapy management requires efficient and ultrasensitive dynamic monitoring of drug p...