Genetics

CRMIPred: Identifying the spatial interactions among cis-regulatory modules via considering their cross-attended epigenetic profiles.

BACKGROUND AND OBJECTIVE: Modular DNA elements known as cis-regulatory modules (CRMs) play central r...

Artificial intelligence assisted multi-model pathological diagnosis of breast cancer based on multispectral autofluorescence images.

Virtual staining technology offers a promising solution to overcome the time-consuming and sample-co...

Foundation Model and Multi-Instance Learning-Based Framework for Predicting Lymphovascular Invasion in Prostate Cancer.

BACKGROUND: Lymphovascular invasion (LVI) is a well-established adverse prognostic factor in prostat...

Translating tumor epigenetic subtyping into methylome network-based prognostic models in early-stage NSCLC: results from the prospective MOBIT study.

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data.

Clustering is commonly used in single-cell RNA sequencing (scRNA-seq) to assess cellular heterogenei...

Beyond the baseline: mapping the context-specific regulatory landscape of disease.

Genome-wide association studies have identified thousands of intergenic variants associated with dis...

Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling.

Intracranial aneurysm (IA) rupture causes severe brain hemorrhage with high mortality, yet its molec...

Computational Redesign of an Ancestral Xylose Isomerase: Tuning the Substrate Preference and Thermostability for Biomass Valorization.

Xylose isomerase is a promising biocatalyst for lignocellulose valorization, but natural enzymes are...

RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss.

BACKGROUND: The molecular landscape of lung adenocarcinoma (LUAD) is often illustrated as a driver-o...

Soft selective sweeps predominate in the yellow fever mosquito Aedes aegypti.

The Aedes aegypti mosquito is a vector for human arboviruses and zoonotic diseases and therefore pos...

Multiclass Radiomics-Based Prediction of BRAF Mutation Status in Pediatric Low-Grade Gliomas Using Multisequence MRI.

BACKGROUND AND PURPOSE: Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in chil...

Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping.

BACKGROUND: Eosinophilic esophagitis (EoE) and its related subtypes-such as EoE-like esophagitis, ly...

Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model.

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...

Microfluidic electroporation for drug and gene delivery: Driving innovation from single-cell precision to high-throughput preclinical and therapeutic platforms.

Intracellular delivery of therapeutic biomolecules represents a fundamental prerequisite for cell-ba...

Identification and validation of ferroptosis-related genes for diabetic nephropathy.

BACKGROUND: Emerging evidence highlights the pivotal role of ferroptosis in the pathophysiology of d...

Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.

Cell migration underlies immune surveillance, tissue repair, embryogenesis, and-when dysregulated-tu...

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, y...

G-quadruplexes and i-motifs: Emerging regulatory elements in plant genomes.

G-quadruplexes (G4s) and i-motifs (iMs) are emerging as key cis-regulatory elements in plant genomes...

Untangling biological complexity: A deep learning approach to separating multiple signals in single-cell data.

Single-cell RNA sequencing (scRNA-seq) provides an instantaneous snapshot of the transcriptional sta...

Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain.

Aging is a major risk factor for neurodegenerative diseases, yet the underlying epigenetic mechanism...

Targeting metabolism to combat anticancer and antibacterial drug resistance.

Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutio...