Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

Exon splicing triggered by unpredicted genetic mutation can cause translational variations in neurod...

Jan 2021 33397809
On the critical review of five machine learning-based algorithms for predicting protein stability changes upon mutation.

A review, recently published in this journal by Fang (2019), showed that methods trained for the pre...

Jan 2021 31885042
Domain-specific introduction to machine learning terminology, pitfalls and opportunities in CRISPR-based gene editing.

The use of machine learning (ML) has become prevalent in the genome engineering space, with applicat...

Jan 2021 32008042
Deep learning-based clustering approaches for bioinformatics.

Clustering is central to many data-driven bioinformatics research and serves a powerful computationa...

Jan 2021 32008043
Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations.

Assessing the causal tissues of human complex diseases is important for the prioritization of trait-...

Jan 2021 33300042
m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome.

N 6-Methyladenosine (m6A) is the most prevalent RNA modification on mRNAs and lncRNAs. It plays a pi...

Jan 2021 32821938
iModulonDB: a knowledgebase of microbial transcriptional regulation derived from machine learning.

Independent component analysis (ICA) of bacterial transcriptomes has emerged as a powerful tool for ...

Jan 2021 33045728
FireProtDB: database of manually curated protein stability data.

The majority of naturally occurring proteins have evolved to function under mild conditions inside t...

Jan 2021 33166383
Open Targets Platform: supporting systematic drug-target identification and prioritisation.

The Open Targets Platform (https://www.targetvalidation.org/) provides users with a queryable knowle...

Jan 2021 33196847
Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.

The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism know...

Jan 2021 33231642
Machine Learning Approaches on High Throughput NGS Data to Unveil Mechanisms of Function in Biology and Disease.

In this review, the fundamental basis of machine learning (ML) and data mining (DM) are summarized t...

Jan 2021 34479914
Applying Machine Learning for Integration of Multi-Modal Genomics Data and Imaging Data to Quantify Heterogeneity in Tumour Tissues.

With rapid advances in experimental instruments and protocols, imaging and sequencing data are being...

Jan 2021 32804368
Synergistic Drug Combination Prediction by Integrating Multiomics Data in Deep Learning Models.

Intrinsic and acquired drug resistance is a major challenge in cancer therapy. Synergistic drug comb...

Jan 2021 32926369
Artificial Intelligence for Epigenetics: Towards Personalized Medicine.

Epigenetics is a field of biological sciences focused on the study of reversible, heritable changes ...

Jan 2021 33208060
Sequence-Based Deep Learning Frameworks on Enhancer-Promoter Interactions Prediction.

Enhancer-promoter interactions (EPIs) in the human genome are of great significance to transcription...

Jan 2021 33234095
Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery.

Artificial Intelligence revolutionizes the drug development process that can quickly identify potent...

Jan 2021 33397265
Using machine learning method to identify as a novel marker to predict biochemical recurrence in prostate cancer.

This study aims to identify novel marker to predict biochemical recurrence (BCR) in prostate cancer...

Jan 2021 33427497
Machine Learning Frameworks to Predict Neoadjuvant Chemotherapy Response in Breast Cancer Using Clinical and Pathological Features.

PURPOSE: Neoadjuvant chemotherapy (NAC) is used to treat locally advanced breast cancer (LABC) and h...

Jan 2021 33439725
Prediction of Rice Transcription Start Sites Using TransPrise: A Novel Machine Learning Approach.

As the interest in genetic resequencing increases, so does the need for effective mathematical, comp...

Jan 2021 33471337
Overcoming Interpretability in Deep Learning Cancer Classification.

Since its inception, deep learning has revolutionized the field of machine learning and data-driven ...

Jan 2021 33606264
Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer.

About a third of patients with kidney cancer experience recurrence or cancer-related progression. Cl...

Jan 2021 33626918
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