Genetics

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Showing 883-903 of 11,060 articles
BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.

BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acq...

Mar 2026 41807883
Discovery of a new binding site and a possible gain in neomorphic activity in R132H_IDH1.

In the Krebs cycle, isocitrate dehydrogenase 1 (IDH1) catalyses the conversion of isocitrate (ICT) t...

Mar 2026 41808665
Prediction model for periodontitis stage based on the salivary microbiome.

This study aimed to characterize salivary microbiome compositions that can classify periodontal heal...

Mar 2026 41810937
Hybrid seed production: new paradigms and challenges in the twenty-first century.

Hybrid seed technology future depends on integrating advanced genomics, AI-driven breeding, and enab...

Mar 2026 41811507
Large-scale paired chain BCR analysis reveals antibody clonal family inference bias and enhances resolution with machine learning.

A fundamental question in immunology is how the adaptive immune system encodes antigen specificity w...

Mar 2026 41811862
mirtronDB 2.0: enhanced database with novel mirtron discoveries.

MOTIVATION: MirtronDB provides a comprehensive and up-to-date resource for advancing mirtron researc...

Mar 2026 41812046
Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine.

Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising i...

Mar 2026 41813599
Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies.

RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS-mitogen-activa...

Mar 2026 41813603
A metabolic-immune subtype of breast cancer defined by G6PD and SHMT2: From single‑cell dissection to dual-targeted therapy.

Breast cancer heterogeneity limits the precision of current prognostic and therapeutic strategies, u...

Mar 2026 41819344
Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling.

Clear cell renal cell carcinoma (ccRCC) is characterized by high metastatic potential and frequent r...

Mar 2026 41864072
Population-level structural variant characterization using pangenome graphs.

Population-level structural variant (SV) profiling is crucial in the era of pangenomes. However, ide...

Mar 2026 41807798
Leveraging proteomics and machine learning for mechanism and biomarker discovery on glioma progression and transformation: from LGG to GBM.

BACKGROUND: Glioma was the most common malignant tumor of the central nervous system in adults. Low-...

Mar 2026 41807981
Deep learning with limited data: a transfer learning approach for transcriptomic survival prediction.

BACKGROUND: Deep neural networks (DNNs) are promising for analyzing high-dimensional transcriptomic ...

Mar 2026 41812364
A targeted proteomics assay for the preoperative diagnosis of thyroid nodules.

Accurate preoperative diagnosis of thyroid nodules via fine-needle aspiration (FNA) biopsy remains c...

Mar 2026 41812663
Computational redesign of a thermostable T7 RNA polymerase.

T7 RNA polymerase (T7 RNAP) is a foundational enzyme for biotechnology, but its utility for many pot...

Mar 2026 41804789
Staphylococcus aureus resistance to non-β-lactam antibiotics: global genomic epidemiology and machine learning feasibility assessment.

Staphylococcus aureus is increasingly resistant to β-lactam antibiotics, making non-β-lactam cell-wa...

Mar 2026 41806067
Nanopore direct RNA sequencing for RNA modification analysis: workflow assessment and computational tool benchmarking.

Recent advancements in sequencing technologies have transformed the characterization of genomic and ...

Mar 2026 41806147
AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remode...

Mar 2026 41807033
The essential role of methylation in maize (Zea mays) defense against the seed-colonizing fungus Aspergillus flavus.

UNLABELLED: The interaction between maize (Zea mays) and Aspergillus species poses a huge threat to ...

Mar 2026 41808726
OSCAR: A Modular Open-Source Robotic Platform for Biological Laboratories.

Biological research often involves complex, repetitive, and high-throughput manipulations that are w...

Mar 2026 41797597
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