Latest AI and machine learning research in genetics for healthcare professionals.
The Nearest Neighbor model is the $\textit{de facto}$ thermodynamic model of RNA secondary structure formation and is a cornerstone of RNA structure prediction and sequence design. The current functional form (Turner 2004) contains $\approx13,000$ underlying thermodynamic parameters, and fitting these to both experimental and structural data is computationally challenging. Here, we leverage recent...
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects millions of women worldwide and is characterized by ovarian dysfunction, hyperandrogenism, and metabolic abnormalities. The traditional diagnostic and therapeutic approaches often fail to address the multifaceted nature of PCOS. Recent advancements in next-generation sequencing (NGS), bioinformatics, and precision medici...
Plants have evolved diverse adaptive mechanisms to sense and respond to environmental stimuli such as cadmium stress. The regulation of gene expressio...
For many years, machine learning-based gene finding approaches have been the central components of eukaryotic genome annotation pipelines, and they r...
Deforestation, urbanization, and climate change have significantly increased the risk of zoonotic diseases. Nipah virus (NiV) of Paramyxoviridae famil...
The properties of biological materials like proteins and nucleic acids are largely determined by their primary sequence. Certain segments in the seque...
While predicting structure-function relationships from sequence data is fundamental in biophysical chemistry, identifying prospective single-point and...
Neuroimaging in ALS has contributed considerable academic insights in recent years demonstrating genotype-specific topological changes decades before ...
BACKGROUND: CD8T cells, also known as cytotoxic T lymphocytes, play a key role in the tumor immune microenvironment (TME) and immune response. The aim...
Inherited platelet disorders (IPDs) are rare conditions with diverse underlying pathophysiology which should be suspected in patients presenting with ...
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer, often diagnosed at advanced stages wi...
Retroviruses such as HIV cause significant diseases in humans and other organisms, making the discovery of antiretroviral (ARV) drugs a critical prior...
Text-to-image (T2I) models have significantly advanced in producing high-quality images. However, such models have the ability to generate images co...
Graph-structured combinatorial problems in complex networks are prevalent in many domains, and are computationally demanding due to their complexity...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, heterogeneous, and systemic disease defined by a suite of symptoms, includin...
Chromosome segmentation in metaphase images is a critical yet challenging task in cytogenetics and genomics due to the inherent complexity, variabilit...
Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially du...
Neurodegenerative diseases (NDD) are characterized by the progressive loss of neurons and the impairment of cellular functions. Messenger RNA (mRNA) h...
Nanopore sequencing allows identification of base modifications, such as methylation, directly from raw current data. Prevailing approaches, including...
As antimicrobial resistance continues to undermine the efficacy of antibiotics, the global medical community is increasingly turning to alternative tr...