Latest AI and machine learning research in genetics for healthcare professionals.
The genome-wide binding of many transcription factors (TFs) depends not only on the presence of their recognition motifs, but also on the surrounding chromatin context. This raises the question of how binding specificity is achieved, which is essential for the proper activation of regulatory regions during developmental and differentiation processes. Two competing hypotheses have been proposed: ei...
The rapid growth of genomic and metagenomic data has underscored the pressing need for advanced computational tools capable of deciphering complex biological sequences. In this study, we introduce Generanno, a compact yet powerful genomic foundation model (GFM) specifically optimized for metagenomic annotation. Trained on an extensive dataset comprising 715 billion base pairs (bp) of prokaryotic D...
Language models starting from biological sequence data are advancing many inference problems, both at the scale of single proteins, and at the scale o...
Understanding how regulatory complexity and constraint shape organismal development remains a central challenge in biology. The developmental hourglas...
The majority of existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to research molecular mechanisms underlying brain-relat...
Alternative splicing (AS) is a central mechanism of gene regulation that enables condition- and tissue-specific expression of gene isoforms. Its dysre...
Deciphering DNA sequences is fundamental to unlocking the mysteries of life, but the high dimensionality and complexity of biological sequence data si...
Cancer morbidity disproportionately affects patients in low- and middle-income countries (LMICs), where timely and accurate tumor profiling is often n...
All physiological processes fundamentally rely on continuous cellular cross-talk to maintain organization and ensure proper function. Among the variou...
The rapid advancement in single-cell, spatial omics, imaging, and genomic technologies requires robust analytical and visualisation platforms capable ...
RNA language models have achieved strong performances across diverse down-stream tasks by leveraging large-scale sequence data. However, RNA function ...
Enzymes accelerate biochemical reactions in living organisms, thus playing an important role in metabolism. Although metabolic pathway databases are g...
Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to restrict invading DNA. They can also be used with si...
Broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) of human immunodeficiency virus-1 (HIV-1) have been utilized in cl...
Endosomal escape remains a major barrier to effective nucleic acid delivery via lipid nanoparticles (LNPs). Here, we address this challenge by incorpo...
DNA methylation (DNAm) plays a key role in mediating phenotypic responses to environmental variation. Various approaches exist to link DNAm variation ...
Single-cell RNA-sequencing (scRNA-seq) enables the study of hierarchical and branching patterns in organismic development at high resolution. Analyzin...
The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteria remain poorly understood. A recent theoretical m...
The Religious Orders Study and Memory and Aging Project (ROSMAP) cohort has generated the world’s most comprehensive single-cell transcriptomic resour...
Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and tight junction...