Latest AI and machine learning research in genetics for healthcare professionals.
Precision medicine aims to identify significant biomarkers and effective drugs tailored to individual genomic profiles, thereby enabling personalized treatment strategies. Drug efficacy is often attributed to drug response, commonly measured as the concentration of a drug required to inhibit a biological activity. In contrast, drug sensitivity reflects how strongly a tumor responds to a drug, wher...
Accurate identification of small molecule binders to RNA is critical for chemical probes and therapeutics. Computational approaches offer a cost-effective strategy to identify small molecules targeting RNA but are often limited by poor predictive accuracy and high computational demands. Here, we introduce Small Molecule Approaches to RNA Targeting Binder Discovery (SMARTBind), a structure-agnostic...
Although individual Mendelian diseases—those caused by a single gene—are rare, their collective disease burden is substantial. Identifying the causal ...
Transcription factors (TFs) regulate gene expression by binding to specific DNA sites on genome, making accurate TF binding site prediction critical f...
Enzymes are extensively utilized for catalyzing the production of value-added compounds in diverse sectors with significant economic impact. However, ...
Scientific discovery in the life sciences remains hindered by fragmented workflows, narrow-scope computational models, and inefficient links between i...
The vast majority of the human genome comprises non-protein-coding regions whose structural and functional roles remain poorly understood. Many of the...
Ensemble of multiple genomic prediction models have grown in popularity due to consistent prediction performance improvements in crop breeding. Howeve...
De novo genome assembly remains a central challenge in computational biology, particularly for diploid genomes where maternal and paternal haplotypes ...
Spatial Transcriptomics (ST) integrates histology with spatially resolved gene expression, offering rich insights into tissue architecture and functio...
Secretion systems play critical roles in bacterial growth, survival, and pathogenesis. Genes encoding secretion system components often co-occur toget...
Persistent environmental pollutants demand the use of diverse microbial metabolic capabilities for effective degradation. While naturally occurring co...
Advancements in whole genome sequencing have increased the number of variants of uncertain significance (VUS) identified in patient genomes. This has ...
Artificial intelligence–assisted scientific prompting is reshaping how biological targets can be rapidly identified and contextualized. In this work, ...
The cannabinoid type-1 receptor (CB1R) signaling pathway plays a central role in regulating motivational and feeding behaviors. Neutral CB1R antagonis...
MicroRNAs (miRNAs) serve critical regulatory roles in gene expression and are valuable biomarkers for early disease detection. However, their inherent...
Antimicrobial Resistance (AMR) is a rapidly escalating global health crisis. While genomic sequencing enables rapid prediction of resistance phenotype...
Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, yet the majority lie in noncoding regions...
Precise profiling of epigenomes is essential for better understanding chromatin biology and gene regulation. Cleavage Under Targets & Tagmentation (CU...
Protein solubility is an attractive engineering target because it is a critical property influencing the scalability of protein production and the suc...