Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcome in Sarcoma.

PURPOSE: Immune checkpoint blockade (ICB) benefits only a subset of sarcoma patients. Biomarkers of ...

Feb 2026 41677857
Ancestry-Associated Performance Variability of Open-Source AI Models for EGFR Prediction in Lung Cancer.

IMPORTANCE: Artificial intelligence (AI) models are emerging as rapid, low-cost tools for predicting...

Feb 2026 41678173
Comprehensive Serum Proteomics Uncovers Epigenetic and Inflammatory Pathways Underlying Primary Open-Angle Glaucoma.

Glaucoma is a leading cause of irreversible blindness, driven by progressive Retinal ganglion cell l...

Feb 2026 41679738
Linking cortical structure and delirium in the elderly: insights from cohort study and shared genetic risk analysis.

BACKGROUND: This study aimed to assess the association between regional cortical changes measured vi...

Feb 2026 41680881
NTDscope: A multi-contrast portable microscope for disease diagnosis.

Accurate diagnostics are essential for disease control and elimination efforts. However, access to d...

Feb 2026 41678589
Toward genomic personalization of breast cancer radiotherapy: foundations, challenges, and a roadmap for clinical integration.

Personalizing radiotherapy dose in breast cancer remains a major unmet need, as current treatment pa...

Feb 2026 41691765
Lactylation-based machine algorithm combined with multi-omics analysis to predict prognosis in cervical cancer.

Although lactylation has been investigated in cancer biology, its mechanistic role in cervical cance...

Feb 2026 41743011
Predicting DNA damage response using synthetic cell painting profiles and experimental analysis.

Detecting DNA damage response (DDR) using cell painting profiles is challenging due to limited sampl...

Feb 2026 41797930
Accelerating rare disease diagnostics by linking DNA and RNA through an explainable and interactive RNA-guided workflow.

Challenges preventing mainstream use of RNA-sequencing (RNA-seq) in genome diagnostics are sources o...

Feb 2026 41685349
Plant genome assembly and annotation.

Plant genome biology is entering a new era defined by fully phased, chromosome-scale, telomere-to-te...

Feb 2026 41678991
Hierarchical multi-resolution deep encoder-decoder network for MRI Brain Tumor segmentation.

So far, many multi-scale encoder-decoder image segmentation architectures have been introduced to ut...

Feb 2026 41604712
Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet mod...

Feb 2026 41669835
DNA Methylation Markers for Pregnancy Hypertension via Machine Learning Methods.

BACKGROUND: This study aims to develop a prediction model to identify individuals at risk of hyperte...

Feb 2026 41669844
Selective multimodal deep learning for reliable breast cancer subtype classification from histopathology and genomic data.

Accurate classification of breast cancer subtypes is critical for personalized treatment plannin...

Feb 2026 41671586
Immune-related biomarkers for major depressive disorder identified via integrated bioinformatics and machine learning.

Background: Major depressive disorder (MDD) is a leading cause of disability worldwide, yet its earl...

Feb 2026 41665627
Multimodal machine learning models for predicting remission in major depressive disorder using clinical data, blood biomarkers, and DNA methylation.

Major depressive disorder (MDD) is a leading global health burden, yet only one-third of patients ac...

Feb 2026 41679390
Characterization of cutaneous wound healing in swine.

The porcine excisional wound model is widely regarded as the most translationally relevant preclinic...

Feb 2026 41853464
Unveiling hidden variables in stressed bacteria.

Phenotypic heterogeneity is a defining feature of bacterial stress responses, long framed as irreduc...

Feb 2026 41671084
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