Genetics

Pharmacological Nuances and Epigenetic Precision: Critical Additions to Plasma Protein-Targeted IBD Research.

Interpretable deep learning model of circulating genomics for quantitative survival prediction in advanced non-small cell lung cancer.

PURPOSE: Accurate quantitative survival prediction in advanced non-small cell lung cancer (NSCLC) re...

Evaluation of Artificial Intelligence-Generated DNA Aptamers Against Treponema pallidum Surface Proteins.

DNA aptamer sequences were selected in silico with assistance from artificial intelligence (AI) usin...

Combating Antiviral Drug Resistance: A Multipronged Strategy.

ConspectusViral proteases are essential enzymes required for viral replication and assembly, making ...

Multidisciplinary prediction of running-related injuries using machine learning.

The causes of endurance running-related injury (RRI) are multifactorial, yet little research has bee...

Single-round evolution of RNA aptamers with GRAPE-LM.

The directed evolution of biomolecules is an iterative process. Although advancements in language mo...

Classification of DNA secondary structures by combining multiple spectral techniques with machine learning.

BACKGROUND: The identification of structural features is an essential prerequisite for the determina...

Neural network-assisted RNA velocity imputation for empowering transcript dynamics-based analyses.

Existing RNA velocity estimation tools often fail to calculate velocities for a substantial portion ...

Mechanism of action of piperine in the treatment of retinal ischemic injury based on bioinformatics and network pharmacology.

Piperine is a common anti-ischemic compound and an active ingredient of herbal medicine for various ...

Non-coding RNAs as prognostic biomarkers in autoimmune disease.

Autoimmune diseases comprise a broad spectrum of disorders in which both the innate and adaptive bra...

Computational Advances in RNA-Small Molecule Binding Site Prediction.

RNA-small molecule interactions are fundamental to cellular regulation and have emerged as highly at...

Comparative analysis of key phagocytic genes in humans and mice using machine learning integrated with single-cell RNA sequencing.

Microglial phagocytosis is essential for neurological recovery after intracerebral hemorrhage (ICH)....

Mamba6mA: A Mamba-based DNA N6-methyladenine Site Prediction Model.

MOTIVATION: N6-methyladenine (6 mA) is an important epigenetic modification of DNA that regulates bi...

From sequence to structure: A comprehensive review of deep learning models for RNA structure prediction.

RNA structure prediction remains one of the most challenging problems in computational biology, with...

IUPAC-induced computational approaches for identifying boosters of small biomolecule functionality: A case study of human tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

This paper introduces several proof-of-concept (PoC) computational methods intended to offer biochem...

Reliable detection of Host-Microbe Signatures in cancer using PRISM.

Recent controversy in the cancer microbiome field highlights the need for more reliable microbial de...

Concordant and Discordant Transcriptomic Signatures of Twin Placentas in the Setting of Preeclampsia.

BACKGROUND: Multifetal pregnancies have increased preeclampsia risk, but the underlying pathogenesis...

Integrative bioinformatics and machine learning approaches identify novel diagnostic signatures for oxaliplatin-resistant colorectal cancer.

BACKGROUND: Oxaliplatin resistance significantly impairs therapeutic outcomes in colorectal cancer. ...

Extracellular vesicles in colorectal cancer: immunomodulation, diagnostics, and therapeutic perspectives.

Colorectal cancer (CRC) remains a significant global health concern and is among the leading causes ...

Enhancing Transcription Factor Regulatory Network Analysis through Data Balancing and Representation Learning.

Transcription factor (TF) and target gene interactions are pivotal in gene regulatory networks, infl...

A hybrid feature extraction framework combining PCA and mutual information for gene expression based lung cancer classification.

Lung cancer remains a leading cause of cancer-related mortality worldwide, with early and accurate d...