Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3' end sequencing data.

Alternative polyadenylation (APA) is a pervasive RNA-processing mechanism in eukaryotes that signifi...

Jan 2026 41620776
A novel explainable deep-learning approach for network analysis of epistatic interactions.

Epistatic interactions of gene loci often determine complex trait phenotypes and may indicate the un...

Jan 2026 41625145
Advancing climate-resilient livestock systems: Next-generation emission mitigation strategies and integrated technological innovations.

Livestock production significantly contributes to global greenhouse gas (GHG) emissions, particularl...

Jan 2026 41705029
Circulating tumor DNA dynamics predict pathological response and guide therapy personalization in the neoadjuvant setting.

Neoadjuvant therapy is a cornerstone of modern oncology, yet its efficacy is traditionally assessed ...

Jan 2026 41611911
Discovery and cultivation of prokaryotic taxa in the age of metagenomics and artificial intelligence.

Despite advances in sequencing, microbial genomics, and cultivation techniques, the vast majority of...

Jan 2026 41615027
RNA modifications in cancer and their detection: a review.

Ribonucleic acid (RNA) modifications, once viewed as static structural features, are now recognized ...

Jan 2026 41615068
Update of the Novara Cohort Study (NCS): protocol evolution of a population-based longitudinal study on ageing in Northern Italy - cohort profile.

PURPOSE: The Novara Cohort Study (NCS) was established to investigate the biological, psychological ...

Jan 2026 41617235
Identification of diagnostic and prognostic biomarkers in lung adenocarcinoma through integrated bioinformatics analysis and real time PCR validation.

Lung cancer is the third most common cancer in the US with a 5-year survival rate of 17%. Non-small ...

Jan 2026 41617774
The METTL3-IGF2BP3 axis drives osteosarcoma progression by enhancing ID1 mRNA stability.

OBJECTIVE: Osteosarcoma (OS) is a highly aggressive malignant bone tumor. While ID1 plays a critical...

Jan 2026 41618233
RNA2seg: a generalist model for cell segmentation in image-based spatial transcriptomics.

Imaging-based spatial transcriptomics enables high-resolution spatial mapping of RNA species. A key ...

Jan 2026 41618375
Parameter-efficient fine-tuning enables scalable transfer of regulatory sequence models to novel contexts.

BACKGROUND: DNA sequence deep learning models can accurately predict epigenetic and transcriptional ...

Jan 2026 41618434
Childhood dyslexia risk elevated by heavy metal mixtures from e-waste: A machine learning-driven mixture modeling study.

Environmental heavy metal mixtures from informal e-waste recycling are potential neurotoxicants, but...

Jan 2026 41617043
Hemoglobin as a Molecular Glue: Toward Potent Inhibition of HbS Polymerization in Sickle Cell Disease.

Sickle cell disease (SCD), a monogenic disorder arising from a single point mutation in the β-globin...

Jan 2026 41612602
From inhibition to regulation: serpins in health and disease.

This issue of the Biomedical Journal highlights regulatory mechanisms that shape aging, disease prog...

Jan 2026 41616576
Evolution of root nodule symbiosis via paleopolyploidy and modular pathway rewiring.

The evolution of root nodule symbiosis (RNS), a key innovation for plant nitrogen acquisition, has l...

Jan 2026 41616777
Three-dimensional phenotyping: Technological advances and applications in genomics-assisted crop breeding.

With rapid advancements in breeding technologies, phenomics, and artificial intelligence, crop breed...

Jan 2026 41618555
Rapid Detection of NDM-Producing Carbapenem-Resistant Escherichia coli Using MALDI-TOF MS Combined with Machine Learning Techniques.

BACKGROUND: Carbapenem-resistant Escherichia coli (CREC) producing New Delhi metallo-beta-lactamase ...

Jan 2026 41619912
Dual Confinement-Enhanced Multiple Single Nucleotide Variant Detection at the Single-Particle Level.

The efficacy of multiple single nucleotide variants (SNVs) analysis is far from ideal due to the lim...

Jan 2026 41604590
Renovating Neural Networks With Viral-Mediated Gene Transfer From A Tissue Contacting Matrix Mimic.

Neurodegenerative diseases such as Huntington's Disease (HD) have a significant impact on healthcare...

Jan 2026 41607219
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