Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND: Gastric cancer remains one of the most prevalent malignancies globally. As early-stage gastric cancer is typically asymptomatic or presents with non-specific symptoms, most patients are diagnosed at advanced stages, leading to poor survival outcomes. Effective early detection strategies are important for reducing gastric cancer-related mortality. In this study, we developed a non-invas...
Primary biliary cholangitis (PBC) is an immune-mediated cholestatic liver disease, and osteoporosis (OP) is a prevalent comorbidity that aggravates the disease burden of PBC patients. Although the co-occurrence of the 2 diseases has been widely observed, the underlying molecular mechanisms remain unclear. Herein, we evaluated the causal link between PBC and OP using Mendelian randomization (MR) an...
Colorectal cancer (CRC) is characterized by high incidence and mortality rates. Early identification of high-risk CRC patients and timely intervention...
Screening for endogenous anabolic-androgenic steroid abuse has long relied on the urinary testosterone/epitestosterone (T/E) ratio. However, this metr...
BACKGROUND: The bark of Magnolia officinalis Rehder & E. Wilson, used in TCM for abdominal distension, pain, and diarrhea, aligns with IBS-D symptoms....
Autoimmune diseases (AIDs) affect 5-10% of the global population, yet effective diagnosis and treatment remain challenging due to their complexity and...
Pheochromocytoma (PCC) and paraganglioma (PGL), collectively referred to as pheochromocytomas and paragangliomas (PPGLs), are rare neuroendocrine tumo...
Mycotoxins, toxic secondary metabolites generated by fungi such as Aspergillus, Fusarium, and Penicillium species pose substantial concerns to food sa...
Nanobodies are antigen-binding proteins of great interest as diagnostics and therapeutics. Accurate and fast characterization of their complementarity...
Bacteria use antagonistic interbacterial weapons, such as polymorphic toxin secretion systems (TSS), to compete for niches in the human gut microbiome...
BACKGROUND: Accurate identification of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal canc...
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the highly lethal and aggressive malignant tumors worldwide. To effectively prevent an...
Advances in metagenomics, deep learning, and generative protein design have enabled broad in silico exploration of sequence space, but experimental ch...
The widespread contamination of the environment with antibiotic residues is a significant factor contributing to the global crisis of antimicrobial re...
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by immune dysregulation and pulmonary vascular remod...
Genome-editing tools for the precise, efficient modification of DNA have led to groundbreaking advances in crop improvement and basic plant science re...
The progression of lung adenocarcinoma (LUAD) is influenced by polyamine metabolism, which modulates antitumor immunity, although the underlying mecha...
The success of COVID-19 mRNA vaccines has made the in-solution stability optimization of mRNAs a key objective. However, we still lack a complete unde...
PURPOSE: magnetic resonance imaging (MRI)-based radiomics has emerged as a promising approach for non-invasive prediction of treatment response in rec...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and limited diagnosti...