Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Droplet Digital CRISPR for Nucleic Acid Detection.

Droplet digital (dd) clustered regularly interspaced short palindromic repeats (CRISPR) integrates t...

Jan 2026 41608958
Organ preservation in rectal cancer: an endoscopist's perspective on current evidence and future directions.

Rectal cancer management has increasingly shifted toward organ-preserving strategies that aim to mai...

Jan 2026 41609210
Unraveling heterogeneity in LUAD via multi-omics integration: molecular classification and therapeutic implications.

Lung adenocarcinoma (LUAD) displays significant morphological and molecular heterogeneity both withi...

Jan 2026 41609946
Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson's disease.

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Pa...

Jan 2026 41611872
Prefrontal cortex-extracellular vesicle RNAs coupling in alcohol use disorder: towards non-invasive biomarkers and targeted therapeutics.

Alcohol use disorder (AUD) poses a substantial global health burden, with its molecular mechanism re...

Jan 2026 41604521
Detecting optimal biomarkers in ovarian cancer cells from high-dimensional mRNA expression data using machine learning.

BACKGROUND AND OBJECTIVE: Reliable detection of robust biomarkers from high-dimensional transcriptom...

Jan 2026 41643488
AI-Guided Conformational Dynamics of p53 L1 Loop Reveal an Allosteric Switch Regulating DNA Binding and Cancer Hotspots.

The tumor suppressor p53 regulates transcription in response to cellular stress, with mutations in i...

Jan 2026 41606807
Lipoprotein(a) Selectively Associates with Vulnerable Coronary Plaque Phenotypes in Comparison with Other Established Risk Markers.

AIMS: Lipoprotein(a) [Lp(a)] is an inherited cardiovascular risk factor. However, its association wi...

Jan 2026 41593891
Expanding role of cell-free DNA for the early diagnosis and monitoring of pulmonary diseases.

Circulating cell-free DNA (cfDNA) has firmly established itself as a cornerstone of liquid biopsy, a...

Jan 2026 41603032
Sperm DNA fragmentation and its influence on mammalian reproduction.

Sperm DNA fragmentation is a recognized factor in male infertility with direct implications for embr...

Jan 2026 41606137
Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review.

Coronary atherosclerosis is a leading cause of morbidity and mortality worldwide and is characterize...

Jan 2026 41593207
Large-scale DNA organization analysis of primary breast cancers for prediction of axillary lymph node metastases.

Breast cancer is the leading cause of cancer-related deaths among women worldwide. It is standard pr...

Jan 2026 41637792
deepNoC: A deep learning system to assign the number of contributors to a short tandem repeat DNA profile.

A common task in forensic biology is to interpret and evaluate short tandem repeat DNA profiles. The...

Jan 2026 41650721
Predicting and interpreting protein and phosphoprotein abundance from pan-cancer and single-cell transcriptomes.

Proteins that impact phenotype and disease are often approximated by RNA expression, which poorly in...

Jan 2026 41816284
Integrated bioinformatics and machine learning deciphering IL12RB2 and FYN as key immune biomarkers in brucellosis.

BACKGROUND: Brucellosis remains a major zoonotic threat worldwide, and early diagnosis is challengin...

Jan 2026 41605052
Role of WNK4 and FKBP5 in asthma: Insights from bioinformatics analysis, machine learning, and preliminary validation.

BACKGROUND: The complex and heterogeneous molecular mechanisms of asthma are currently unclear, and ...

Jan 2026 41610713
Evaluation of a machine learning system for genomic antimicrobial susceptibility determination on a clinically representative test set.

UNLABELLED: Next-generation sequencing is anticipated to transform infectious disease treatment by e...

Jan 2026 41589861
AI-Guided Design and Predictive Modeling of Synthetic Escherichia coli Promoters through Comprehensive -10/-35 Box Engineering.

Promoters are essential in transcriptional regulation, with the -10 and -35 boxes playing a critical...

Jan 2026 41589500
Benchmarking Density Functional Theory for Accurate Calculation of Nitride Band Gaps.

We benchmark exchange-correlation functionals for the calculation of fundamental band gaps of inorga...

Jan 2026 41591797
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