Latest AI and machine learning research in genetics for healthcare professionals.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, caused by various epigenetic and genetic factors. This has resulted in an unclear understanding of etiology and biomarkers associated with ASD. In this study, we used RNA Seq datasets integrating with machine learning models to identify the differentially expressed genes (DEGs) between ASD and typical development (TD). The RNA Seq da...
Cancer is a heterogeneous disease, with numerous subtypes differing in molecular profiles, risk factors, clinical outcomes, and tumor locations. Lung cancer, the third most diagnosed cancer in the United States, is driven by a complex combination of molecular alterations, which influence tumor behavior and patient outcomes. Large-scale consortia such as The Cancer Genome Atlas (TCGA) have generate...
Genome editing has revolutionized molecular biology. It offers precise modification of genetic material across diverse organisms. This review outlines...
Microbe Decoder is a web server that predicts functional traits of microbes in microbiome sequencing datasets. Sequencing has revealed thousands of or...
Biliary tract cancer (BTC) is typically diagnosed at an advanced stage due to the lack of effective screening tools, resulting in limited therapeutic ...
Spinal cord injury (SCI) profoundly impairs patients' quality of life and imposes a substantial economic burden on society, often resulting in irrever...
Despite the success of targeted therapies in rheumatoid arthritis, the lack of predictive biomarkers of response leads to an empirical treatment appro...
The rapid growth of lipid nanoparticle (LNP)-based RNA therapeutics demands predictive tools to accelerate formulation and lipid design, yet developme...
BACKGROUND: Viral respiratory tract infections (vRTIs) are a leading cause of paediatric hospitalisation and healthcare utilisation. Existing syndromi...
Indigenous Cannabis sativa populations exhibit remarkable diversity in their flowering-time responses to photoperiod cues, reflecting adaptation to va...
Inherited genetic variation can weaken the ability of the immune system to detect and eliminate malignant cells, limiting the effectiveness of cancer ...
BACKGROUND AND AIM: COPD is a common respiratory disease characterized by progressive airflow restriction that severely affects patients' quality of l...
Recent advances in generative artificial intelligence (AI) have enabled the de novo design of genome-editing nucleases. For example, OpenCRISPR-1 offe...
BACKGROUND: Conventional cytogenetic analysis remains central to the diagnosis and risk stratification of hematological malignancies but is constraine...
BACKGROUND: Low-grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein-coupled receptors (GPCR) contribute to glioma mal...
BACKGROUND: Wilms tumor presents a heterogeneous tumor microenvironment. This study aimed to characterize the tumor microenvironment and identify prog...
Lignocellulosic biomass (LCB), a second-generation feedstock for cellulosic ethanol production, requires efficient pretreatment. This step is critical...
Ischemic stroke (IS) is a leading cause of death and long-term disability worldwide, with a complex and multifactorial pathophysiology that is still i...
Nonviral polymeric vectors offer a tunable platform for nucleic acid delivery, yet formulation variables beyond polymer structure remain underexplored...
PURPOSE: Missense variants represent a large proportion of variants of uncertain significance (VUS) in clinical genetics. The ClinGen framework now en...