Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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G.AI: an AI-driven platform for phenotype standardization, variant interpretation and structured clinical reporting in rare disease genomic diagnosis.

BACKGROUND: The diagnosis of rare diseases increasingly relies on the interpretation of high-through...

Jun 2026 42251412
Integrated multi-omics and experimental validation reveal CSK and FBLN1 as key targets of stanozolol in accelerating atherosclerosis.

BACKGROUND: Stanozolol, a synthetic anabolic androgenic steroid (AAS) widely abused to enhance perfo...

Jun 2026 42250865
Predictive modeling of urinary 8-hydroxy-2ยด-deoxyguanosine (8-OHdG) in metal workers: A comparative study of machine learning algorithms in toxicology.

Urinary 8-hydroxy-2ยด-deoxyguanosine (8-OHdG), a biomarker for oxidative DNA damage, is commonly used...

Jun 2026 42246313
Resolving variants of uncertain significance in neurofibromatosis: An integrated approach combining deep learning and minigene assays.

Neurofibromatosis (NF) comprises genetic disorders mainly caused by pathogenic variants, yet its phe...

Jun 2026 42247039
Machine Learning-Guided Survival Prediction and Treatment Sequencing in Advanced Soft Tissue Sarcoma Beyond Second-Line Therapy: A Retrospective Cohort Study.

INTRODUCTION: Evidence guiding the optimal sequencing of later-line systemic therapy in advanced sof...

(1)
Jun 2026 42247057
Deep learning for H&E-based meningioma molecular classification and outcome prediction: a retrospective cohort study.

BACKGROUND: The introduction of genomic profiling as a tool for molecular classification and clinica...

Jun 2026 42248714
Multidimensional proteomics and explainable AI feature selection identify cross-platform lung cancer molecular signature in blood plasma.

BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide despite the availability ...

Jun 2026 42249069
Multiscale learning of gene network-driven phenotypic dynamics of single cells.

Understanding how gene regulatory networks (GRNs) dynamically orchestrate cell fate emergence remain...

(1)
Jun 2026 42249125
Deconstructing cancer in 3D: models, mechanisms, and personalized solutions.

Three-dimensional (3D) cancer models, notably patient-derived organoids (PDOs), address the critical...

Jun 2026 42249357
Identification MYD88 as a candidate molecule of sodium overload-induced cell death in myocardial ischemia-reperfusion injury.

BACKGROUND: Myocardial ischemia-reperfusion (I/R) injury disrupts intracellular ion homeostasis, tri...

Jun 2026 42249419
Identification of potential key efferocytosis-related genes in rheumatoid arthritis using machine learning.

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial infl...

Jun 2026 42243611
Decoding neuron-specific lineage to identify diagnostic biomarkers and therapeutic targets for ischemic stroke.

Ischemic stroke (IS) imposes a major global health burden. To uncover new diagnostic and therapeutic...

Jun 2026 42291234
Benchmarking reveals the superiority of nucleic acid foundation models in predicting lncRNA coding potential.

BACKGROUND: A subset of long noncoding RNAs (lncRNAs) contains short open reading frames and can enc...

(2)
Jun 2026 42243956
Understanding resistance in glioblastoma: insights into personalized and targeted therapeutic strategies.

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despi...

Jun 2026 42248236
Multi-omics analysis identifies CD48 and ITIH5 as potential diagnostic biomarkers and therapeutic targets for metabolic disorders associated with obesity.

BACKGROUND: Obesity-driven metabolic disorders involve pathological remodeling of white adipose tiss...

Jun 2026 42248268
Machine Learning Reveals the Contribution of Rare Genetic Variants and Enhances Risk Prediction for Coronary Artery Disease in the Japanese Population.

BACKGROUND: GWASs (genome-wide association studies) have advanced our understanding of coronary arte...

Jun 2026 42237915
Predicting Treatment Response After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

OBJECTIVE: To develop a predictive model for pathological complete response (pCR) after total neoadj...

Jun 2026 42240534
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