Latest AI and machine learning research in genetics for healthcare professionals.
Poorly soluble drug delivery is a long-standing core challenge in the pharmaceutical field. With a drug loading capacity close to 100% and no requirement for carrier materials, nanosuspensions offer an ideal solution for delivering poorly soluble drugs. By reducing the drugs particle size to 100-500 nm, the nanosuspensions exhibited satisfied surface area and dissolution kinetics improvement. Howe...
The structural dynamics of DNA underpin essential biological processes, yet conventional structural biology methods often obscure conformational heterogeneity through ensemble averaging. Atomic force microscopy (AFM) provides single-molecule topographical maps capable of capturing both local and global variation, but extracting quantitative insight from these images remains challenging. Here, we i...
The discovery of CRISPR-Cas system has significantly advanced genome editing, offering vast applications in medical treatments and life sciences resea...
AIMS: Long QT syndrome (LQTS) is a life-threatening genetic disorder characterized by prolonged QT intervals on electrocardiograms. Congenital forms a...
Plant cell walls are complex networks of polysaccharides that underpin plant structure and provide dietary fibers that promote human health. These pol...
Sequence-based deep learning has advanced genome interpretation, yet most models remain task-specific and rely on retraining, limiting scalability acr...
Organoids offer a powerful platform to model human development and disease in vitro, while preserving key features of in vivo tissue architecture and ...
The assessment of tumor-infiltrating lymphocyte (TILs), together with gene expression signatures (GES), has the potential to guide personalized breast...
This century, global human health has been marked by a seemingly increasing list of outbreaks and epidemics caused by RNA viruses - masters of rapid e...
Autonomous microrobots can reach hard-to-access regions in the human body for minimally invasive therapy. However, their microscale size limits the in...
The global demand for plasmid DNA (pDNA) is rapidly increasing due to its key role in the manufacture of mRNA vaccines and advanced therapy medicinal ...
The number of possible variants representing the landscape of a protein sequence of length N residues, made of the standard unmodified proteinogenic a...
INTRODUCTION AND AIMS: Oral exfoliative DNA aneuploidy cytology by image cytometry (DNA-ICM) has been introduced for the early diagnosis of malignant ...
Cellular senescence is increasingly recognized as a fundamental driver of cardiovascular ageing; however, its molecular heterogeneity, cell-type speci...
BACKGROUND: Human aneuploid conception, a leading cause of infertility, pregnancy loss, and congenital disorders (e.g. Down's syndrome), arises from e...
Foodborne pathogens present a major threat to global public health. However, conventional detection methods and equipment are often unsuitable for the...
Sugar crops, including but not limited to sugarcane, sugar beet, sweet sorghum and stevia, are major sources of sugar production in the world. However...
Single-cell RNA sequencing (scRNA-Seq) enables analysis of gene expression at single-cell resolution. RNA velocity analysis infers the temporal dynami...
Chronic tendinopathy is typified by persistent tendon-associated pain, transmitted by local nociceptive neurons. However, the regulatory function of s...
OBJECTIVE: To assess the diagnostic performance of semen RNA-based biomarkers for detecting prostate cancer and differentiating cancer grade groups. M...