Genetics

Integrated Single Cell Spatial Analysis Reveals Dysregulated Basal Progenitor Cells in Ulcerative Colitis Pathogenesis: A Multi Omics Study.

BACKGROUND AND AIMS: Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes persisten...

Automated high-throughput microscopy screening unveiled new Listeria monocytogenes genes involved in cell infection.

To uncover novel genetic factors required for Listeria monocytogenes cell infection, we developed an...

NEIL1 suppresses ROS accumulation to promote temozolomide resistance and malignant progression in glioma cells.

BACKGROUND: Glioma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the stand...

Programmable Smart CAR-T design: A new paradigm in precision immunotherapy driven by logic gates, conditional activation, allogeneic strategies, and artificial intelligence.

Chimeric antigen receptor T-cell (CAR-T) therapy has achieved unprecedented success in hematological...

Identifying endoplasmic reticulum stress-related key genes of vascular dementia using bioinformatics and biological experiments.

Vascular dementia (VaD) is the second most common type of dementia, yet its pathogenesis is not full...

Recent advances in the neurogenomics of autism spectrum disorder.

Neurogenomics has provided exceptional insights into the genetic architecture underlying autism spec...

WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens...

Analysis and regulation of baijiu aroma-active compounds: integrating metabolomics, sensory genomics, and artificial intelligence.

Baijiu aroma is governed by a small number of odor-active compounds present at trace or ultra-trace ...

GCLSC: Single-cell clustering model based on graph contrastive learning.

The advent of single-cell RNA sequencing (scRNA-seq) technology has enabled the analysis of cellular...

A causal bidirectional selective state space model for imaging genetics in neurodegenerative diseases.

Brain imaging genetics aims to uncover the pathological mechanisms and improve the diagnosis of brai...

Author's Reply: Unrecognized Biases and Validation Gaps in TraceOrg for Automated Autosomal Dominant Polycystic Kidney Disease Volumetry.

Unrecognized Biases and Validation Gaps in TraceOrg for Automated Autosomal Dominant Polycystic Kidney Disease Volumetry.

A multi-target therapeutic framework for Alzheimer's disease: an integrative mechanistic review.

BACKGROUND: Alzheimer's disease (AD) is increasingly recognized as a multifactorial network disorder...

Artificial intelligence and machine learning in antimicrobial discovery, resistance prediction, and precision therapy.

OBJECTIVES: The global crisis of antimicrobial resistance (AMR) demands a paradigm shift in traditio...

Metabolic engineering of Pichia pastoris for high-efficiency production of branched-chain amino acids -enriched single-cell protein.

Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential nutrien...

Machine learning and causal inference applied to the gut metagenome-metabolome axis reveals a link between neonatal jaundice and autism spectrum disorder.

UNLABELLED: Neonatal jaundice (NJ) might increase the risk of autism spectrum disorder (ASD) in chil...

Haplotype-resolved genome reveals allele-aware epigenetic and 3D chromatin regulation of heterosis in the tea hybrid.

Heterosis, widely used in plant breeding to enhance yield and quality, is not yet fully understood a...

Enhancer Dynamics for Gene Regulation in the Cardiovascular System.

Enhancers are regulatory DNA sequences that increase the transcription of a target gene when bound b...

Emerging Diagnostic Indications for Endoscopic Ultrasound.

Endoscopic ultrasound (EUS) has evolved from a diagnostic imaging tool into a versatile platform tha...

Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation.

RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisens...

Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes.

Single-walled carbon nanotubes (SWCNTs) functionalized with single-stranded DNAs can function as nea...