Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND: Soybeans are widely cultivated worldwide as an important source of edible vegetable oil and protein. Due to climate change, it is repeatedly exposed to various abiotic stressors in its natural habitat. Abiotic stresses such as heat, drought, and salinity severely restrict soybean productivity, yet the conserved molecular mechanisms underlying multi-stress tolerance remain poorly unders...
BACKGROUND: Machine-learning models based on tissue transcriptomic data are powerful tools for disease classification. However, their clinical adoption is limited by the invasive nature of tissue sampling. Furthermore, transcriptomic datasets are often affected by batch effects and gene-level noise, which compromise model generalizability across platforms and clinical cohorts. METHODS: We develope...
Point-of-care (POC) biosensing holds great promise for noninvasive cancer diagnostics, as circulating tumor DNA (ctDNA) serves as a minimally invasive...
Cell fate transitions are driven by regulatory circuitry, yet RNA velocity models cellular dynamics without explicitly accounting for gene regulatory ...
Tubulointerstitial diseases represent a heterogeneous group of kidney diseases with diverse causes and overlapping histopathologic and immunophenotypi...
Immune cell engineering has emerged as a transformative frontier in medicine, reshaping therapeutic strategies for cancer, autoimmunity and infectious...
Cronobacter species are emerging foodborne pathogens, and species identification is essential because the virulence of different species is diverse, w...
Three-dimensional (3D) chromatin architecture is a fundamental regulatory layer for linking hierarchical chromatin organization to gene expression and...
Metabolic dysfunction-associated fatty liver disease (MASLD) is a highly prevalent liver condition with a complex etiology increasingly linked to air ...
INTRODUCTION: Plasma proteins reflect the combined influence of both internal and external factors, making proteomics-based aging clocks a promising a...
Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiac disease and a leading cause of heart failure, arrhythmia, and sudden cardiac d...
BACKGROUND: Intervertebral disc degeneration (IDD) is a leading cause of global disability. This study aimed to systematically investigate the role of...
BACKGROUND: Periprosthetic joint infection (PJI) remains one of the most serious complications after joint arthroplasty, and accurate diagnosis contin...
One significant advancement in synthetic biology is the development of synthetic gene circuits with predictive Boolean logic. However, there is no uni...
This paper proposes a novel Large Language Model (LLM)-assisted hyper-heuristic evolutionary algorithm framework (LLMHHEA) to enhance the accuracy of ...
Loss-of-function mutations in the autism-associated CHD8 gene are highly penetrant for trait and behavioral abnormalities in children, but there is su...
First-in-class (FIC) oncology drugs-defined by their novel mechanisms of action or targeting of previously unaddressed molecular targets-have emerged ...
BACKGROUND: Cirrhosis and sarcopenia frequently coexist and are associated with poor clinical outcomes; however, their shared genetic basis remains in...
Breast cancer is associated mostly with women; however, breast cancer also appears in men, which dictates the need to know about gender-specific diffe...
OBJECTIVE: To evaluate a novel image-based deep learning method for the automated identification of inherited retinal diseases (IRDs) and to explore t...