Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Molecular diagnostics in clinical microbiology: Advances, applications, and future directions.

Molecular diagnostics have transformed clinical microbiology by enabling rapid, accurate, and highly...

Dec 2025 41406849
The best from both disciplines: integrating human and microbial signatures from whole genome sequencing to advance cancer diagnostics.

Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, a...

Dec 2025 41369197
An Exosome-Based Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer: The ENCODER Multicenter Study.

BACKGROUND & AIMS: The incidence of early-onset colorectal cancer (EOCRC; diagnosed before age 50 ye...

Dec 2025 41364052
Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia.

INTRODUCTION: Blood-based biomarkers that can aid diagnosis of Parkinson's Disease (PD) dementia (PD...

Dec 2025 41385896
CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

Epigenetic macromolecular enzyme complexes tightly regulate gene expression at the chromatin level a...

Dec 2025 41364533
Fully automated Res3DNet model to predict IDH mutation of gliomas from whole-brain MRI free of tumor segmentation.

Accurate prediction of IDH mutation status in gliomas is critical for guiding diagnosis, prognosis, ...

Dec 2025 41531733
Transcriptome-wide RNA Stability Across Cancers Reveals Therapeutic Vulnerabilities.

The steady-state abundance of mRNA is governed by the interplay between transcription and degradatio...

Dec 2025 41371605
scSemiPLC: a semi-supervised learning framework for annotating single-cell RNA-Seq data by generating pseudo-labels through clustering.

UNLABELLED: Single-cell RNA sequencing (scRNA-seq) technology enables researchers to explore heterog...

Dec 2025 41358754
Deep learning assisted PfAgo-programmable genetic circuit for ultrasensitive visual detection of foodborne pathogen in one-tube.

Foodborne pathogens represent a significant threat to public health. The development of rapid and se...

Dec 2025 41418735
Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review).

Prostate cancer remains one of the most prevalent malignancies and a major cause of cancer‑related m...

Dec 2025 41347816
Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review).

Alternative splicing (AS) is one of the principal mechanisms of post‑transcriptional regulation that...

Dec 2025 41347834
Bioinformatics applications in pharmacogenomics: towards personalized medicine.

Pharmacogenomics investigates how genetic variation influences individual responses to drug therapy ...

Dec 2025 41352693
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.

DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted b...

Dec 2025 41349541
Integrated m6A reader network in acute myeloid leukemia: prognostic modeling, immune modulation, and functional validation of YTHDF3.

Emerging evidence highlights RNA N6-methyladenosine (m6A) modifications as pivotal regulators of tum...

Dec 2025 41349468
Genomic assessment of reproduction traits in Holstein dairy cattle across 3 lactations using additive genetic models and post hoc random forest analysis.

The typical objective of genomic analyses is to assess additive genetic variance in traits. However,...

Dec 2025 41349814
Prediction of IDH-mutation and 1p19q-codeletion status in adult-type diffuse gliomas using three-class radiomics models.

PURPOSE: To predict the genetic subtypes of adult-type diffuse gliomas with three-class MRI radiomic...

Dec 2025 41364966
Machine learning-assisted photoelectrochemical biosensor based on DNA-AgNCs nanowires for exosomal lncRNA intelligent diagnosis.

BACKGROUND: Exosomal long non-coding RNA (lncRNA) as a burgeoning biomarker, its abnormal expression...

Dec 2025 41513350
Biological multi-omics approaches to next-generation biomarkers in immune-related disorders and malignancies: An overview.

Cancer and autoimmune diseases are major global health challenges characterized by molecular and cli...

Dec 2025 41324821
Graph-based deep learning approach for high-throughput protein-DNA interaction scoring.

Accurately quantifying protein-DNA interactions (PDIs) is critical for understanding biological proc...

Dec 2025 41326808
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