Latest AI and machine learning research in genetics for healthcare professionals.
DNA methylation-based age prediction has become a reliable method for individual identification. While current models have achieved high accuracy when targeting a single type of biological fluid, crime scenes often contain multiple body fluids. Applying single fluid models to other fluid types may result in significant prediction errors, potentially misleading investigations. Therefore, age predic...
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a leading global health burden, yet its diagnosis and staging rely heavily on invasive liver biopsies. Liquid biopsy, utilizing circulating cell-free DNA (cfDNA), offers a promising noninvasive alternative to capture hepatic genomic instability. This review consolidates current knowledge on cfDNA biomarkers in MASLD, movin...
Next-generation sequencing (NGS) has revolutionized the field of genomics by providing rapid, high-throughput, and cost-effective platforms for analyz...
BACKGROUND: Host dependency factors (HDF) are essential for viral replication and are promising targets for broad-spectrum antivirals. However, most w...
OBJECTIVE: Diabetic kidney disease (DKD) is a leading microvascular complication of diabetes in which vascular smooth muscle cell (VSMC) senescence pl...
Variability in Alzheimer's disease (AD) clinical presentation complicates mechanistic studies and therapeutic outcome prediction. Brain protein aggreg...
BACKGROUND: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor ...
Since the emergence of synthetic biology, biofoundries have developed as enabling infrastructures that scale engineering biology globally. Landmark in...
BACKGROUND: Ovarian cancer (OC) is a leading cause of cancer-related mortality in women, largely due to the lack of effective strategies for early det...
Strong non-invasive tests (NITs) are needed to predict decompensation in patients with compensated advanced chronic liver disease (cACLD) and improve ...
As dairy enterprises increasingly focus on microbial contamination, traditional detection technologies are gradually showing limitations in terms of d...
The application of artificial intelligence in computational pathology depends on both robust algorithms and high-quality, clinically reliable data. Pr...
While the heterogeneity and co-occurrence of heritable neurodevelopmental conditions such as autism, attention deficit hyperactivity disorder (ADHD), ...
PURPOSE: Placental growth factor (PGF) is associated with the progression of hepatocellular carcinoma (HCC), but current research on this relationship...
The efficacy of PD-1 inhibitor pucotenlimab (HX008) in solid tumors exhibits heterogeneity. This study integrated data from 6 clinical trials (coverin...
Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, se...
BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence larg...
BACKGROUND: The prediction of Epidermal Growth Factor Receptor (EGFR) mutation status in advanced lung adenocarcinoma is crucial for targeted therapy....
INTRODUCTION: Subtle PD motor abnormalities can be underappreciated in examination but are overtly present in handwriting. Spiral, meander, and wave d...
BACKGROUND/AIM: Chemotherapy with gemcitabine and cisplatin remains the cornerstone of treatment for advanced urothelial carcinoma (UC), yet response ...