Latest AI and machine learning research in genetics for healthcare professionals.
OBJECTIVES: Transarterial chemoembolization (TACE) is a promising locoregional therapy for unresectable colorectal liver metastases, but patient selection remains challenging. We aimed to develop and validate prognostic radiomics-based machine learning models in a multicenter, prospectively collected drug-eluting microsphere TACE cohort. MATERIALS AND METHODS: We retrospectively analyzed 76 patien...
Autonomous laboratories hold great promise for accelerating materials discovery but often inherit hidden limits because experimental boundaries have been predefined by human intuition or literature precedents. Such a priori constraints risk excluding feasible regions, particularly since synthesizable conditions can shift with hardware or environmental factors. We present SPACESHIP, an AI framework...
Most genetic variants in the human genome reside in non-coding regions, where they can perturb regulatory element activity to influence gene expressio...
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity in complex biological systems. However, analyzin...
BACKGROUND: As a critical hallmark of systemic lupus erythematosus, lupus nephritis (LN) stands as a major organ-threatening condition driven by sophi...
BACKGROUND: The process of fracture healing encompasses tightly regulated cellular and molecular interactions. However, the precise regulatory mechani...
The human microbiome is ubiquitous across nearly all body sites and exhibits biological characteristics that enable stable detection under diverse env...
Squamous cell carcinomas of unknown primary (SCCUP), accounting for approximately 5% of head and neck malignancies, present significant clinical chall...
BACKGROUND: Placenta is a focal point of cellular interactions of maternal and fetal immune systems, fostering immune tolerance essential for a succes...
Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in metastatic castration-sensitive prostate canc...
BACKGROUND: The identification of reliable biomarkers for atrial fibrillation (AF) recurrence post-catheter ablation remains a clinical challenge. Thi...
INTRODUCTION: Autoimmune thyroid diseases (AITDs), including Graves' disease and Hashimoto's thyroiditis, arise from genetic, epigenetic, and environm...
BACKGROUND: The role of extrachromosomal DNA (ecDNA)-related genes in osteosarcoma remains largely unexplored. The aim of this study is to investigate...
Prioritizing a reliable list of cancer-associated epigenetic regulators (cERs) is critical for cancer diagnosis and discovery of drug targets. While v...
Amyloid fibrils, a form of peptide aggregates, are associated with multiple diseases and hinder the development of therapeutics. The experimental char...
PTEN hamartoma tumor syndrome (PHTS), caused by germline PTEN mutations, exhibits pleiotropic manifestations, including hamartomas, cancers, and neuro...
Establishing viable solid-state synthesis pathways for novel inorganic materials remains a major challenge in materials science. Previous pathway desi...
Lipid nanoparticle (LNP) delivery of RNA therapeutics is constrained by poor tissue selectivity and off-target toxicity. Most high-throughput screenin...
The generation of transcript variants via alternative utilisation of transcription start sites (TSSs) is a pivotal regulatory mechanism in physiologic...