Genetics

Integrating deep learning and pangenomics to recover missing heritability from wild structural variations.

Crop domestication has induced a severe genetic bottleneck that reduces the adaptive diversity present in modern cultivars. Standard intra-population genomic prediction models reliant on linear reference genomes and SNPs fail to capture the full spectrum of phenotypic variance hidden in wild relatives. Realizing this potential requires broadening the predictive paradigm from selection within narro...

Identification of Mitotic Catastrophe-related Prognostic Genes in Lung Adenocarcinoma via Transcriptome Analysis.

Lung adenocarcinoma (LUAD), the most common lung cancer subtype, exhibits a poor prognosis. Although mitotic catastrophe can be induced in LUAD, leading to cell death, the prognostic and biological significance of mitotic catastrophe-related genes (MCRGs) in this disease remains unclear. Differentially expressed genes (DEGs) associated with LUAD were screened from the TCGA-LUAD cohort, and overlap...

Digital Biobanking in the Era of Artificial Intelligence.

The terminology "Biobank" is used for the organized collection of biological materials consisting of tissue samples, blood, serum, body fluids, and DN...

Comparative identification of abiotic stress-responsive differentially expressed genes in chickpea using unsupervised machine learning, and traditional meta-analysis.

BACKGROUND: Climate change poses a growing threat to chickpea production through abiotic stresses such as drought, heat, and salinity. Understanding t...

AI Structural Biology in Nephrology: Powerful Scaffolds, Fragile Certainties.

Artificial intelligence (AI)-based protein structure prediction has rapidly entered nephrology, providing plausible atomic models for channels, transp...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging.

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet prod...

Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis.

BACKGROUND & AIMS: Cholangiocarcinoma (CCA) is a major complication of primary sclerosing cholangitis (PSC), with a 20-year incidence of ∼15%. Early d...

Exploring and validating hub genes associated with atopic dermatitis through weighted gene co-expression network analysis and machine learning.

This study aimed to identify novel biomarkers of atopic dermatitis (AD) and investigate their pathogenic mechanisms. We analyzed 7 AD-related datasets...

Multidisciplinary dental treatment planning by artificial intelligence: A comparative evaluation.

PURPOSE: The purpose of this study was to evaluate and compare four AI software programs-ChatGPT-5, Microsoft Copilot, Google Gemini (V 2.5), and Open...

Integrative systems biology identifies PSMB2 as a core oxidative stress-associated target in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) represents one of the most aggressive and therapeutically challenging subtypes of breast cancer, characterized by...

RNA splicing in health and disease.

RNA splicing expands the functional output of eukaryotic genomes by enabling individual precursor messenger RNA (pre-mRNA) to generate multiple mature...

Interpretable distillation reveals that deep learning splicing models suffer from pervasive confounders and blind spots.

BACKGROUND: Predicting RNA splicing from genomic sequence is a crucial task for understanding gene regulation and interpreting genetic variation. Rece...

Single-photon emission computed tomography/computed tomography-based radiomics of bone metastases for predicting epidermal growth factor receptor mutation status and targeted therapy efficacy in non-small-cell lung cancer.

BACKGROUND: This study aimed to develop a single-photon emission computed tomography/computed tomography (SPECT/CT)-based radiomics model using bone m...

Distinguishing common respiratory pathogens using machine learning of symptom profiles to prioritize diagnostic testing.

Clinical symptoms are critical for diagnosing and managing upper respiratory tract infections, yet systematic comparisons across common pathogens rema...

A hypersensitive neuromorphic airflow sensor inspired by vision-compensatory scorpion mechanoreceptors for respiratory pattern analysis.

Efficient acquisition of spatial airflow information is vital for organisms to orient within complex environments and detect predators. For scorpions ...

Toward foundation-model-assisted biomechanical simulation of the knee joint: Current evidence, limitations, and future directions.

Subject-specific finite element analysis (FEA) can estimate tissue-level stress, strain, contact pressure, and load transfer in the knee, but building...

Advanced gene editing technologies for oncology mechanisms, applications, and clinical implementation.

Advanced gene editing tools have transformed oncology by facilitating precise molecular therapies aimed at the hereditary basis of cancer. This thorou...

Downstream-Aware Automated QC of Images and AI-Generated Segmentations.

Automated deep learning-based segmentation is increasingly used in medical imaging to enable rapid biomarker extraction. Manual quality control (QC) o...

[Paeoniflorin alleviates cancer-related fatigue during chemotherapy for breast cancer by targeting EZH2/CCNE1 to regulate cell cycle and inflammatory microenvironment].

OBJECTIVES: To explore the molecular mechanisms and key pharmacodynamic basis of Baishao for alleviating cancer-related fatigue (CRF) during chemother...

[Reflections on surgical management strategies for locally advanced gastric cancer after neoadjuvant immunotherapy].

Neoadjuvant immunotherapy is reshaping the treatment landscape of locally advanced gastric cancer (GC). The central clinical challenge has expanded fr...