Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND: Renal fibrosis (RFib) is a final common pathway in chronic kidney disease (CKD) progression. Although 5-methylcytosine (m5C) RNA modification can regulate mRNA fate, its role in RFib and redox-regulated cell death remains incompletely defined. METHODS: Public GEO cohorts were analyzed to identify dysregulated m5C regulators and enriched pathways in RFib. RFib was modeled in vivo using ...
Trained immunity is defined as the epigenetic and metabolic reprogramming of innate immune cells, conferring enhanced or diminished responsiveness to secondary challenges following initial stimulation. Immune tolerance represents the state of immunological unresponsiveness to self-antigens or innocuous foreign antigens. Systems pharmacology approaches have emerged as essential tools for understand...
Bioinformatics has transformed modern virology by linking genomic variation to epidemiology, protein structure, and public health action. This review ...
OBJECTIVE: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, against high-throughput functional scores from saturati...
BACKGROUND: Osteoarthritis (OA) represents the most common degenerative joint disease, with emerging evidence linking it to lysosomal dysfunction and ...
Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been associated with the development of various malignant tumors. H...
Programmed cell death (PCD) and cellular immunity play pivotal roles in colorectal cancer (CRC) progression; understanding their crosstalk and identif...
Liquid biopsy via plasma cell-free DNA (cfDNA) is transforming precision medicine by enabling non-invasive insights into the genomic and epigenomic la...
BACKGROUND: The exact molecular mechanisms governing a heightened risk of chronic spontaneous urticaria (CSU) associated with autophagy remain largely...
BACKGROUND: Gestational diabetes mellitus (GDM) remains a prevalent and heterogeneous pregnancy complication with limited strategies for early identif...
BACKGROUND: Proteins regulate diverse biological processes through interactions with other molecules, including RNAs. RNA-binding proteins (RBPs) are ...
Establishing a cell type-specific chromatin landscape is crucial for the maintenance of cell identity during embryonic development. However, our knowl...
BACKGROUND: Stress has been negatively associated with reproductive outcomes, including poor semen quality in men; however, the molecular mechanisms u...
BACKGROUND: Thoracic aortic aneurysm (TAA) is a life-threatening disease with limited therapeutic options, largely due to an incomplete understanding ...
Urinary tract infections (UTIs) are diagnosed based on symptoms and confirmed by urine culture, despite its limitations in sensitivity. False-negative...
AIMS/HYPOTHESIS: Clinically actionable biomarkers that accurately reflect the health status of the beta cell are needed to improve risk stratification...
Human telomerase reverse transcriptase (hTERT) plays a key role in cancer cell immortalization and represents an important therapeutic target for anti...
Leptospirosis is difficult to diagnose because of protean nonspecific clinical manifestations and the lack of rapid, actionable laboratory testing. A ...
The ability of RNA-binding proteins to form complexes with other biomolecules underpins a broad range of structural properties and functions. Understa...
Insects comprise millions of species, many experiencing severe population declines under environmental and habitat changes. High-throughput approaches...