Genetics

Enhanced Dhole Optimization Algorithm for hyperparameter tuning of a TCN-BiGRU-MHA hybrid architecture for wind power forecasting.

This study presents Temporal Convolutional Network-Bidirectional Gated Recurrent Unit-Multi Head Attention (TCN-BiGRU-MHA) hybrid deep learning model optimized with the Enhanced Dhole Optimization Algorithm (EDOA) for wind power estimation using real-world wind turbine data. The original Dhole Optimization Algorithm (DOA) exhibits limitations such as early convergence, getting stuck in local optim...

Enhanced multicancer screening assay through whole-genome methylation sequencing-based multimodal cell-free DNA analysis.

The rapid and accurate detection of multiple cancers presents considerable challenges, especially for stage I disease, due to the low concentration and heterogeneous nature of circulating tumor DNA. Here we introduce an enhanced multicancer screening assay that integrates whole-genome methylation sequencing with an innovative multimodal analytical framework for cell-free DNA. The ensemble machine ...

Amino acid metabolism in retinal diseases: Mechanisms, diagnostics, and therapeutic opportunities.

Amino acid metabolism serves as a central hub linking retinal energy supply, neurotransmission, and cell signaling, which is critical for maintaining ...

Whole genome sequencing precision medicine strategy to shorten treatment for rifampicin-resistant tuberculosis (SMARTT): a pragmatic, randomised, single-blind phase 4 trial.

BACKGROUND: All patients with rifampicin-resistant tuberculosis should receive a short course of effective treatment. We aimed to evaluate the effecti...

The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.

The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift, an...

Identification and Experimental Validation of Biomarkers Associated with PI3K/AKT Signaling Pathway in Spinal Cord Injury.

Spinal cord injury (SCI) refers to trauma to the spinal cord resulting in functional deficits. Dysregulation of the phosphoinositide 3-kinase/serine-t...

In vivo CAR-cell therapy: current challenges and emerging therapeutic advances.

In vivo chimeric antigen receptor (CAR) cell therapy is undergoing a transformative shift from conventional ex vivo manufacturing toward in situ cellu...

Optimizing Pichia Pastoris Cell-Free Protein Synthesis to Improve Economics.

Cell-free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the ge...

Turbocharging crop breeding with integrated biotechnology for a climate-resilient future.

Global agriculture faces unprecedented challenges from climate change and population growth, creating an urgent demand for the rapid development of re...

Variant Calling in the Dark Genome: Benchmarking SNV Calls in the Flanks of Structural Variants.

Single nucleotide variant calling protocols routinely discard calls in the regions immediately flanking structural variants (often 50 bp either side) ...

Integrating multi-encoding sequence features via stacking ensemble learning for RNA m5C site prediction.

RNA 5-methylcytosine (m5C) is an important epitranscriptomic modification involved in RNA stability, translation, and post-transcriptional regulation....

Optimal treatment selection for hepatocellular carcinoma in the era of immunotherapy.

Immunotherapy has revolutionized hepatocellular carcinoma (HCC) management, necessitating personalized strategies in current guidelines. Despite curat...

Clinician-deployable deep hypergraph model integrating clinical and CT radiomics predicts immunotherapy outcomes in NSCLC.

Current image-based deep learning models that predict the benefits of immunotherapy in non-small cell lung cancer (NSCLC) require high-performance har...

Deciphering the molecular network of Trichostatin A in regulating Alzheimer's disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation.

BACKGROUND: Histone deacetylases (HDACs) regulate neuroprotection; however, Trichostatin A (TSA), an HDAC inhibitor, lacks clear molecular mechanisms ...

SOHO State of the Art Updates and Next Questions | Management of Primary Central Nervous System Lymphoma.

Primary Central Nervous System Lymphoma (PCNSL) is a rare and aggressive form of extranodal non-Hodgkin lymphoma. Recent insights into the molecular c...

plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis-Derived Variants in Liquid Biopsies from Patients with Solid Tumors.

PURPOSE: Targeted next-generation sequencing (NGS) of cell-free DNA (cfDNA) enables comprehensive molecular profiling and can guide the selection of g...

Clinical Machine Learning Model for Predicting Pathological Complete Response in Patients with Esophageal and Gastroesophageal Junction Adenocarcinoma After Trimodality Therapy.

BACKGROUND: Accurate prediction of pathological complete response (pCR) after preoperative chemoradiation therapy, followed by surgery (trimodality th...

From Time-Limited Therapy to Treatment-Free Observation: The Evolving Role of MRD in CLL Management.

The integration of measurable residual disease (MRD) into the management of chronic lymphocytic leukemia (CLL) has emerged as a major advance in risk ...

Genomic characterization and breed identification of Wannan Yellow-feathered chicken using whole-genome resequencing and machine learning.

Accurate identification of indigenous chicken breeds is fundamental for the conservation and utilization of poultry genetic resources. To enable relia...

Advances in Oral Cavity Stem Cell Research Revealed through Multi-omics Analysis.

Oral stem cell research encompasses the study of dental pulp stem cells, periodontal ligament stem cells, regeneration of dental pulp and periodontal ...