Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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CD27 Neutralization Attenuates Rheumatoid Arthritis by Suppressing.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and de...

Apr 2026 42033547
Enhancing genomic prediction for key production traits in chickens through ultrasound phenotyping and multi-model comparative analysis.

BACKGROUND: Growth performance and carcass traits are economically vital in poultry breeding. In Wen...

Apr 2026 42032674
A hybrid deep learning framework for accurate N6,2'-O-Dimethyladenosine site prediction.

N6,2'-O-dimethyladenosine (m6Am) is a critical RNA modification that plays a pivotal role in regulat...

Apr 2026 42054815
Integrative multi-kingdom gut microbiome analysis uncovers clinical signatures of major depressive disorder.

BACKGROUND: Accumulating evidence indicates that gut microbiome is significantly altered in major de...

Apr 2026 42035799
Machine learning-based prediction of Familial Hemiplegic Migraine risk from genetic variants.

BACKGROUND: Familial Hemiplegic migraine (FHM) is a rare migraine subtype characterised by transient...

(1)
Apr 2026 42033889
Dango: Predicting higher-order genetic interactions.

Higher-order genetic interactions have profound implications for understanding the molecular mechani...

Apr 2026 42034054
Evaluation of computational tools for the prediction of CRISPR/SpCas9 gRNA activity in plants.

CRISPR/Cas9 technologies are now routinely used in plant research, with guide RNA (gRNA) design bein...

Apr 2026 42029722
Probing the Specificity of Fluorescent Deoxyribozymes Using Single-Step Selections and Machine Learning.

The ability of proteins and nucleic acids to form specific binding sites for ligands is critical for...

Apr 2026 42030482
Convolutional neural networks quantify antibiotic resistance in Mycobacterium tuberculosis with diagnostic grade accuracy and predict treatment response.

There is considerable interest in training machine learning (ML) models on genomic data that achieve...

(1)
Apr 2026 42031767
Transferability of a US claims-based machine learning model for ATTRwt-CM identification: a retrospective evaluation in a German setting.

Cardiac amyloidosis (CA), a fatal and progressive cardiomyopathy is characterized by amyloid deposit...

(1)
Apr 2026 42031926
Gene-level gut microbiome signatures as predictive biomarkers for response to immune checkpoint inhibitors across multiple cancer types.

Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CT...

Apr 2026 42026803
CNV-Hub: an integrated web-based platform for CNV classification and interpretation using multi-algorithm consensus.

Copy number variations (CNVs) are genomic alterations that can cause rare genetic diseases. Their in...

Apr 2026 42038408
The promise of AlphaFold for gene structure annotation.

Most new genomes lack annotation, automated methods are error-prone, and few genomes are ever manual...

(1)
Apr 2026 42033219
Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning.

Deep mutational scanning (DMS) has been extensively used to investigate how single-position mutation...

Apr 2026 42030951
MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells.

BACKGROUND: Emerging evidence links cellular ageing and biophysical alterations with cancer suscepti...

Apr 2026 42031621
Predicting microbial community responses to disturbance using genome-resolved trait-based life-history strategies.

Understanding how microbial communities respond to disturbance remains a fundamental question in eco...

Apr 2026 42023670
IL11⁺ fibroblasts are implicated in non-response to anti-TNFα via fibrosis in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is frequently accompanied by intestinal fibrosis, with non-response...

Apr 2026 42024442
DNA methylation-based classification of hematolymphoid neoplasms.

Accurate pathological diagnosis of hematolymphoid neoplasms (HLN) is often challenging due to their ...

Apr 2026 42024465
Target-site Dynamics Explain a Large Share of Apparent MicroRNA Differential Expression.

MicroRNA (miRNA) abundance reflects a dynamic balance between biogenesis, target engagement, and dec...

Apr 2026 42025302
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