Latest AI and machine learning research in genetics for healthcare professionals.
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality, and early diagnosis and personalized therapy are constrained by complex molecular mechanisms. We integrated high-throughput bulk RNA sequencing with weighted gene co-expression network analysis (WGCNA) to prioritize AMI-associated genes, externally validated findings in two independent cohorts, and screened candi...
Transcription factors establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility and regulating gene expression1. Mapping accessible chromatin offers critical insights into transcriptional control, but available datasets for human development are restricted to bulk tissue, single organs or single modalities2. He...
Similar to proteins, many RNAs fold into three-dimensional (3D) structures to perform biological functions. Here we present the trRosettaRNA server, a...
Industrial microorganisms combine genomic robustness with process resilience to achieve high-level bioproduction, and these traits are usually governe...
BACKGROUND: Major depressive disorder (MDD) is common and disabling, and antidepressant selection often follows a trial-and-error process. Predictix i...
N6-methyladenosine (m6A) is the most common mRNA modification and plays key role in RNA metabolism, gene regulation, and disease. Accurate identificat...
The widespread use of CRISPR-Cas9 (Clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9) in plants highlights the nee...
The CRISPR-Cas12a system offers a promising platform for simple and sensitive nucleic acid diagnostics, including tumor-associated variant detection a...
Identifying and understanding cryptic pockets remains a compelling goal in drug discovery, as they can offer new avenues for targeting proteins that a...
BACKGROUND: Lung adenocarcinoma (LUAD) is the predominant pathological subtype of non-small cell lung cancer. Its considerable tumor heterogeneity and...
OBJECTIVE(S): Periodontitis is a chronic inflammatory disease characterized by progressive alveolar bone destruction. While lipid metabolism and neutr...
Accurate RNA 3D structure evaluation on candidates is critical for accurate RNA 3D structure predictions. Although some knowledge-based potentials and...
The normal tension glaucoma (NTG) has limited drug options since current antiglaucoma medications are mostly designed to decrease intraocular pressure...
OBJECTIVE: Current tissue-based methods for ruling out endometrial cancer in symptomatic women are highly invasive. We explored whether non-invasive v...
Genomic diagnostics is revolutionizing disease management and forms the cornerstone of precision medicine. This review details the multi-stage operati...
Cancer therapy-related cardiac dysfunction remains a major cause of morbidity among cancer survivors and may interrupt life-saving oncologic therapy o...
Respiratory disease classification using lung sound analysis offers a non-invasive and cost-effective diagnostic alternative to traditional imaging-ba...
BACKGROUND: Mammograms contain imaging biomarkers that can predict future breast cancer risk using deep learning (DL) models. We evaluated whether add...
OBJECTIVE: Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy characterized by metabolic reprogramming and immune dysregul...
Warnings of pathogens manufactured to target a specific ethnic group, so-called genetic bioweapons, have recently received considerable media attentio...