Genetics

FDCSNPS: A Fast Division Calculation SNP System.

Spiking Neural P system (SNP system) is a distributed parallel computing model inspired by the infor...

Bringing AI to Cancer's Regulatory Genome.

A new AI model that predicts how noncoding DNA mutations alter gene regulation is helping cancer res...

CRISPR-Cas system: recent advancements in prompt diagnosis of high-risk HPV genotypes in cervical cancer.

INTRODUCTION: The CRISPR/Cas system has emerged as a highly versatile platform for diagnosing infect...

Predictive modeling of gene expression and localization of DNA binding site using deep convolutional neural networks.

Despite the sequencing revolution, large swaths of the genomes sequenced to date lack any informatio...

Sonogenetics for Precision Medicine: A Focus on Immunoengineering and Genome Engineering.

Ultrasound can penetrate centimetres of soft tissue, focus energy with millimetre precision, and ope...

An end-to-end generalizable deep learning framework to comprehensively analyze transcriptional regulation.

Genome annotation currently requires performing dozens of molecular assays in hundreds of cell and t...

Vietnamese Odonata: bridging global biodiversity, ecological, and conservation gaps in a changing world.

Vietnam is a global hotspot, hosting 493 Odonata species, with ~95% evaluated by the IUCN. Odonata s...

Gene regulatory landscape dissected by single-cell four-omics sequencing.

Cellular diversity is governed not only by the transcriptome but also by multiple layers of epigenom...

Deep learning framework for predicting EGFR mutation status from H&E whole slide images in lung adenocarcinoma.

A novel deep learning-driven framework for improving lncRNA comprehensive annotation with LncADeep 2.0.

MOTIVATION: Long non-coding RNAs (lncRNAs) have emerged as crucial players in diverse physiological ...

Bulk Microarray and Single-Cell Transcriptomic Analyses Reveal Bacterial Lipopolysaccharide-Related Biomarkers in Sepsis.

Sepsis, a life-threatening condition triggered by dysregulated host response to infection, poses sig...

StabLyzeGraph: High-throughput screening of combinatorial mutations using graph neural networks.

Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a...

Enhanced Glioma Genotype Prediction Using CEST MRI With Full Z-Spectrum Input, Pixel-Level Learning, and Majority Voting.

Accurate glioma genotype prediction, such as the isocitrate dehydrogenase (IDH) mutation and O6-meth...

Artificial intelligence in nongynecologic cytology: A systematic review of current research and commercial tools.

BACKGROUND: Nongynecologic (non-GYN) cytology plays an important role in cellular and molecular canc...

Usefulness of Artificial Intelligence for Surgical Support in Robot-assisted Distal Pancreatectomy: A Preliminary Case Report.

BACKGROUND/AIM: The incidence of postoperative complications in minimally-invasive surgery for pancr...

Single-Cell Transcriptomic Analysis of Chemotherapy-Induced Changes in Osteosarcoma With a Pyroptosis-Related Gene-Based Prognostic Model.

Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challeng...

A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer.

The tissue-level processes underpinning metastatic outgrowth remain unclear. We combined single-cell...

Learning multi-cellular representations of single-cell transcriptomics data enables characterization of patient-level disease states.

Single-cell RNA sequencing (scRNA-seq) is a prominent tool for studying human disease biology. The a...

Testosterone-Sparing Treatment Strategies for Biochemically Recurrent Prostate Cancer After Radical Prostatectomy.

PURPOSE OF REVIEW: Biochemical recurrence (BCR) after radical prostatectomy occurs in up to one-thir...

Seeing and Feeling DNA Methylation: Single-Molecule Biophysics Meets Machine Learning.

DNA methylation at 5-methylcytosine (5mC) is crucial for embryonic development and cellular function...

Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution.

VDAC2's known role in cancer and immune regulation via enhancing the CD8+ T cell-mediated killing, a...