Geriatrics

Latest AI and machine learning research in geriatrics for healthcare professionals.

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Hippocampal grey matter changes across scales in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disease of the central ...

A Systematic Fairness Evaluation of Racial Bias in Alzheimer’s Disease Diagnosis Using Machine Learning Models

Alzheimer’s disease (AD) is a major global health concern, expected to affect 12.7 million Americans...

Robust prediction of drug combination side effects in realistic settings

Side effects caused by drug combinations pose a major challenge in healthcare. Knowledge of these si...

Long-Read epigenetic clocks identify improved brain aging predictions

Epigenetic clocks are widely used to estimate biological aging, yet most are built from array-based ...

Cooperative multi-view integration with Scalable and Interpretable Model Explainer

Single-omics approaches often provide a limited perspective on complex biological systems, whereas m...

Accurate and efficient phylogenetic inference through end-to-end deep learning

Accurate phylogenetic inference is crucial for understanding evolutionary relationships among specie...

Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection

This study critically reevaluates the utility of brain-age models within the context of detecting ne...

One-Class Bioacoustic Detector for Monitoring the Critically Endangered Pied Tamarin (Saguinus bicolor)

The pied tamarin (Saguinus bicolor) is a critically endangered primate with a small geographic range...

HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease

Alterations in metabolism, stress response, sleep, circadian rhythms, and neuroendocrine processes a...

MRI-based classifier to identify close-to-onset cases in C9orf72 genetic frontotemporal dementia

Predicting symptom onset in genetic frontotemporal dementia (FTD) is crucial for advancing targeted ...

Scale-dependent brain age with cosmological higher-order statistics from structural magnetic resonance imaging

Inferring chronological age from magnetic resonance imaging (MRI) brain data has become a valuable t...

Neural Underpinnings of Olfactory Dysfunction across Parkinson’s and Alzheimer’s Spectra

Olfactory dysfunction is a frequent yet understudied feature of neurodegenerative spectrum disorders...

A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons

Joint pain is an increasing concern for our aging population, as current therapies to slow joint dis...

Facial photographs as proxies for inflammatory aging

Systemic chronic inflammation is a major determinant of aging and disease risk, yet current biomarke...

From Circles to Signals: Representation Learning on Ultra-Long Extrachromosomal Circular DNA

Extrachromosomal circular DNA (eccDNA) is a covalently closed circular DNA molecule that plays an im...

PRSNet-2: End-to-end genotype-to-phenotype prediction via hierarchical graph neural networks

The emergence of large-scale biobanks has opened unprecedented opportunities for the development of ...

The influence of power-training and aging on endomysium content and fiber cross-sectional area in the human soleus muscle

The Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) set ...

Bridging Language Markers and Pathology: Correlations Between Digital Speech Measures and Surrogate CSF Biomarkers in Alzheimer’s Disease

Digital language markers show promise in detecting early cognitive impairment related to Alzheimer’s...

Automatic measurement of temporalis muscle thickness from CT head scans using deep learning

To construct and validate a deep-learning (DL) model for the automatic quantification of temporalis ...

MARRVEL-MCP: A Context-Engineered Natural-Language Query-to-Response Interface for Mendelian Disease Discovery

Rare disease variant interpretation requires navigating multiple genomic databases with strict input...

Direct Training of Networks of Morris-Lecar Neurons with Backprop

Spiking Neural Networks (SNNs) have the potential to replicate the brain’s computational efficacy by...

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