Geriatrics

Radiomics-enhanced 18F-AV45 PET/MRI for integrative assessment and centiloid estimation of amyloid-β burden in Alzheimer's disease.

OBJECTIVE: Reliable assessment of cerebral amyloid-β (Aβ) deposition is essential for the diagnosis and management of Alzheimer's disease (AD). This study aimed to evaluate the feasibility of integrating radiomics-enhanced 18F-florbetapir positron emission tomography/magnetic resonance imaging (18F-AV45 PET/MRI) features for Aβ status evaluation and to further explore their potential for continuou...

Integrating chronological aging and asynchronous aging for enhanced biological age prediction using artificial intelligence model.

The accurate estimation of biological age (BA) is limited by the reliance on chronological age (CA), which does not account for asynchronous aging-heterogeneity in individual aging trajectories. To address this, we propose a unified artificial intelligence framework that explicitly integrates CA with a quantifiable measure of asynchronous aging for BA prediction. We quantify asynchronous aging ind...

GENIE: A Two-Stage Interpretable Deep Learning Framework for Revealing the High-Order Genetic Interaction Network of Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. The underlying mechanisms ...

End-to-End PET/CT Interpretation and Quantification with an LLM-Orchestrated AI Agent: A Real-World Pilot Study.

Although deep learning models have improved individual PET analysis, image processing, and quantification tasks, end-to-end automation from raw DICOM ...

High-throughput signal detection of hepatotoxic drug-drug interactions in hospitalized elderly patients: an NLP-driven pharmacovigilance study.

BACKGROUND: Elderly patients are highly susceptible to drug-drug interaction (DDI)-induced liver injury, yet comprehensive real-world evidence remains...

Identification of depression types and key influencing factors among rural elderly in China: a comprehensive analysis based on machine learning and network analysis.

BACKGROUND: Depression poses a severe public health challenge for older adults, especially in rural China. In rural settings, the heavy burden of chro...

From out-of-pocket to prepaid financing? projected health expenditure and financing mix in Egypt, 1995-2050.

BACKGROUND: Egypt's health financing is characterised by persistently high out-of-pocket (OOP) payments exceeding 50% of total health expenditure and ...

Psychometric performance and student perceptions of AI- versus student-generated multiple-choice questions: a single-center randomized controlled trial.

BACKGROUND: Developing high-quality multiple-choice examinations in medical education is time- and resource-intensive. Large language models (LLMs) of...

Development of an Arterial Carbon Dioxide Estimation Model Using End-Tidal Carbon Dioxide Levels during Surgery in the Pediatric Population.

BACKGROUND: Intraoperative arterial carbon dioxide partial pressure monitoring is essential for pediatric ventilatory management but requires invasive...

Clinical Implementation of Opportunistic Screening for Osteoporosis.

Opportunistic screening leverages existing imaging examinations performed for unrelated routine clinical indications to systematically extract quantit...

Novel aptamers targeting heparan sulfate for delivery of RNA therapeutics in Alzheimer's disease.

Heparan sulfate (HS) proteoglycans are abundant, sulfation-patterned glycosaminoglycans on brain cells and the neurovascular unit that interact with a...

Allergic rhinitis in the elderly. In collaboration with ARIA guidelines.

Rhinitis in the elderly represents a unique challenge, due to specific clinical profiles, needs and expectations. Allergic rhinitis (AR) in the elderl...

Clinical Validation of the MC-80 Digital Morphology Analyzer in Leukocyte Classification: A Large-Scale Comparison With Manual Microscopy.

INTRODUCTION: Although AI-powered digital morphology analyzers are widely used for leukocyte classification, their reliability in detecting clinically...

Computer-aided diagnosis system for thoracic computed tomography of rib fractures in older emergency patients: A preliminary study.

The peculiarities of older individuals related to osteoporosis and hyperostosis may lead to a higher rate of misdiagnosis of rib fractures on computed...

Leveraging Natural Language Processing and Structured Scoring to Evaluate Operative Note Quality in Surgical Training.

OBJECTIVE: To evaluate resident versus attending operative notes using a two-phase approach combining natural language processing (NLP) diffing and st...

Radiomics-based unsupervised clustering and deep learning nomogram for response prediction after neoadjuvant chemotherapy in locally advanced laryngeal cancer.

OBJECTIVES: To develop a nomogram model for individualized prediction of neoadjuvant chemotherapy (NAC) response in locally advanced laryngeal cancer ...

Prediction of Alzheimer's disease risk factors from retinal images via deep learning: Development and validation of biologically relevant morphological associations in the UK Biobank.

BackgroundThe systemic, metabolic, lifestyle factors have established associations with Alzheimer's disease (AD) through epidemiologic and AD-specific...

Web-Based Gamified Auditory-Cognitive Dual-Task Training for Older Adults With Age-Related Hearing Loss: Pilot Randomized Controlled Trial.

BACKGROUND: Everyday listening ability is essential for individual health and well-being. Age-related hearing loss (ARHL) is associated with reduced c...

Implementing Digital Respiratory Technologies for People With Respiratory Conditions: Scoping Review.

BACKGROUND: Digital health offers opportunities for safe, equitable, and accessible care, and its integration into respiratory care is a strategic pri...

Expert Consensus Statement on Acoustic Metrics for Swallowing Dysfunction Screening in Older Adults: A Delphi Study.

OBJECTIVE: Swallowing dysfunction poses significant health risks for older adults. Early detection is crucial to prevent complications such as aspirat...