Ophthalmology

Glaucoma

Latest AI and machine learning research in glaucoma for healthcare professionals.

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GLLaucoMed: A Secure LLM-Powered Agentic Workflow for Automated Medication Extraction from Free-Text Glaucoma Clinical Notes

Purpose: To evaluate the efficacy of large language models (LLMs) in extracting medication-related information from glaucoma clinical notes in the electronic health record (EHR). Design: Cross-sectional. Subjects: 1,250 subjects in the Bascom Palmer Ophthalmic Repository. Methods: Extracted clinical notes from glaucoma-related encounters between 2014 and 2024 were labeled by two glaucoma specialis...

Ellipse Meets Bit-Planes: A Novel Approach to RNFL based Glaucoma Detection Using Advanced Image Processing and Deep Learning

This work proposes an integrated pipeline for automatic glaucoma detection method from easily available colour fundas images based on an adaptive algorithm for ellipse-based polar transformation, to enhance the analysis of the Retinal Nerve Fiber Layer (RNFL) as the primary biomarker for observing glaucomatous changes, regardless of optic disc and macula position. Utilizing this transformation, we...

Jun 14 2026 2606.15772v1
DiffSight-Former: Modeling Structural Differences and Temporal Dynamics for Glaucoma Progression Prediction

Glaucoma is a leading cause of irreversible blindness worldwide, and early detection from fundus images is critical for effective disease management. ...

Jun 8 2026 2606.09140v1
Neovascular Glaucoma at a Tertiary Centre in Finland, 2008-2024: A Retrospective Cohort Study

Background/Aims: Neovascular glaucoma (NVG) is an aggressive secondary glaucoma with limited longitudinal data. This study reports the aetiologies, tr...

Developing and Evaluating Deep Learning Approaches for Visual Field Denoising in Glaucoma

Purpose To investigate the relative efficacy of nine distinct visual field (VF) denoising artificial intelligence (AI) methods and a pathology-aware A...

Deriving OCT-Equivalent Retinal Nerve Fiber Layer Thickness Maps from Fundus Photographs with Deep Learning Improves Glaucoma Diagnosis

Purpose: To develop and evaluate a deep learning model that predicts optical coherence tomography (OCT)-equivalent retinal nerve fiber layer thickness...

Deep Learning Prediction of Personalized Peripapillary Retinal Nerve Fiber Layer Thickness Norms from Fundus Images in Glaucoma

Purpose: To predict retinal nerve fiber layer thickness (RNFLT) norms from fundus images. Methods: We selected 18,000 OCT scans and visual fields (VF)...

Design and Validation of an AI-Assisted Sequential Screening Framework for Psychological Distress in Glaucoma

Purpose: Psychological distress is highly prevalent in glaucoma and is associated with worse adherence, reduced quality of life, and faster disease pr...

Language-dependent diagnostic safety of medical AI systems: a cross-lingual benchmarking and prospective clinical study

Background Patients worldwide receive healthcare in many languages, yet medical AI systems are validated almost exclusively in high-resource languages...

The German National Cohort: Ophthalmological Assessment, Baseline Profile and Potential for AI-based Eye Research

Objective: To describe the ophthalmic examination protocol within the German National Cohort (NAKO) / NAKO Gesundheitsstudie, to report the baseline p...

Deep Kernel Learning for Stratifying Glaucoma Trajectories

Effectively stratifying patient risk in chronic diseases like glaucoma is a major clinical challenge. Clinicians need tools to identify patients at hi...

May 1 2026 2605.00708v1
Validating a Deep Learning Algorithm to Identify Patients with Glaucoma using Systemic Electronic Health Records

We evaluated whether a glaucoma risk assessment (GRA) model trained on All of Us national data can identify patients at high probability of glaucoma u...

Apr 22 2026 2604.20921v1
Fundus Image-based Glaucoma Screening via Retinal Knowledge-Oriented Dynamic Multi-Level Feature Integration

Automated diagnosis based on color fundus photography is essential for large-scale glaucoma screening. However, existing deep learning models are typi...

Apr 14 2026 2604.12351v1
Nested Radially Monotone Polar Occupancy Estimation: Clinically-Grounded Optic Disc and Cup Segmentation for Glaucoma Screening

Valid segmentation of the optic disc (OD) and optic cup (OC) from fundus photographs is essential for glaucoma screening. Unfortunately, existing deep...

Apr 10 2026 2604.09062v1
Retinal Layer Segmentation in OCT Images With 2.5D Cross-slice Feature Fusion Module for Glaucoma Assessment

For accurate glaucoma diagnosis and monitoring, reliable retinal layer segmentation in OCT images is essential. However, existing 2D segmentation meth...

Mar 25 2026 2603.24115v1
CataractSAM-2: A Domain-Adapted Model for Anterior Segment Surgery Segmentation and Scalable Ground-Truth Annotation

We present CataractSAM-2, a domain-adapted extension of Meta's Segment Anything Model 2, designed for real-time semantic segmentation of cataract opht...

Mar 23 2026 2603.21566v1
Multimodal Machine Learning for Glaucoma Detection in a Sub-Saharan African Clinical Population

Purpose: To evaluate the performance of machine learning models for automated glaucoma detection using multimodal clinical, structural, and functional...

Joint Segmentation and Grading with Iterative Optimization for Multimodal Glaucoma Diagnosis

Accurate diagnosis of glaucoma is challenging, as early-stage changes are subtle and often lack clear structural or appearance cues. Most existing app...

Mar 15 2026 2603.14188v1
GLEAM: A Multimodal Imaging Dataset and HAMM for Glaucoma Classification

We propose glaucoma lesion evaluation and analysis with multimodal imaging (GLEAM), the first publicly available tri-modal glaucoma dataset comprising...

Mar 13 2026 2603.12800v1
CausalFund: Causality-Inspired Domain Generalization in Retinal Fundus Imaging for Low-Resource Screening

Early screening for glaucoma and diabetic retinopathy (DR) is critical to prevent irreversible vision loss, yet remains inaccessible to many underserv...

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