Ophthalmology

Glaucoma

Latest AI and machine learning research in glaucoma for healthcare professionals.

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Dual-Field Microvascular Segmentation: Hemodynamically-Consistent Attention Learning for Retinal Vasculature Mapping

Accurate retinal Microvascular segmentation demands a balanced combination of anatomical fidelity and hemodynamic relevance. However, existing methods fall short in preserving critical structures such as capillary junctions and bifurcations, thus limiting clinical applications and causing fragmentation. To address these limitations, we propose DFMS-Net, a novel dualfield segmentation framework tha...

Equity-Enhanced Glaucoma Progression Prediction from OCT with Knowledge Distillation

To develop an equitable deep learning model with knowledge distillation to enhance the demographic equity in glaucoma progression prediction. We developed a novel deep learning model called FairDist which used baseline optical coherency tomography (OCT) scans to predict glaucoma progression. First, an equity-aware EfficientNet termed EqEffNet was trained for glaucoma detection. Next, the pretraine...

Performance of DeepSeek, Qwen 2.5 MAX, and ChatGPT Assisting in Diagnosis of Corneal Eye Diseases, Glaucoma, and Neuro-Ophthalmology Diseases Based on Clinical Case Reports

This study evaluates the diagnostic performance of several AI models, including Deepseek, in diagnosing corneal diseases, glaucoma, and neuro□ophthalm...

Enhancing Glaucoma Detection through Supervised Pre-training with Intermediate Phenotypes: A Multi-Institutional Study

Glaucoma is a leading cause of irreversible blindness worldwide, with early diagnosis often hindered by subtle symptomatology and the lack of comprehe...

Datasheet for the IDHea Primary Eye Care Dataset: A Real-World Ocular Imaging Resource for Research

Real-world ocular imaging datasets are essential for advancing research in artificial intelligence (AI), autonomous disease screening, and clinical de...

Detecting neurodegenerative changes in glaucoma using deep mean kurtosis-curve–corrected tractometry

Glaucoma is increasingly recognized as a neurodegenerative condition involving both retinal and central nervous system structures. Here, we present an...

Assessing the Potential of AI-Driven Drug Repurposing in Ophthalmology: An Analysis of ChatGPT’s Therapeutic Recommendations

This study aimed to evaluate the novelty and potential value of therapeutic suggestions made by an artificial intelligence large language model for tr...

GlaucoRAG: A Retrieval-Augmented Large Language Model for Expert-Level Glaucoma Assessment

Purpose: Accurate glaucoma assessment is challenging because of the complexity and chronic nature of the disease; therefore, there is a critical need ...

AI-GUIDED ENDPOINT SELECTION FOR NEUROPROTECTION TRIALS IN GLAUCOMA

Standard Automated Perimetry (SAP) is the mainstay for monitoring glaucoma progression and has been accepted by the U.S. Food and Drug Administration ...

Comparison of Foundation and Supervised Learning-Based Models for Detection of Referable Glaucoma from Fundus Photographs

To compare the performance of a foundation model and a supervised learning-based model for detecting referable glaucoma from fundus photographs. Evalu...

Clinically Informed Semi-Supervised Learning Improves Disease Annotation and Equity from Electronic Health Records: A Glaucoma Case Study

Clinical notes represent a vast but underutilized source of information for disease characterization, whereas structured electronic health record (EHR...

Artificial Intelligence Powered Research Automation (AIPRA) Versus Human Expert: A Two-Arm Ophthalmology Comparative Study

To compare the quality and efficiency of an AI-powered research automation (AIPRA) workflow with a conventional human-led workflow for producing a ful...

Explainable Deep Learning for Glaucoma Detection: A DenseNet121-Based Classification with Grad-CAM Visualization

One of the main causes of permanent blindness in the globe, glaucoma frequently advances symptomlessly until it reaches an advanced stage. Recent deve...

Multimodal Prediction of Primary Open-Angle Glaucoma Using Polygenic Risk Scores and Clinical Features in a High-Risk African Ancestry Cohort

Primary open-angle glaucoma (POAG) disproportionately affects individuals of African ancestry, yet early detection tools remain limited. Using the lar...

Multimodal Deep Learning for Longitudinal Prediction of Glaucoma Progression Using Sequential RNFL, Visual Field, and Clinical Data

Forecasting glaucoma progression remains a major challenge in preventing irreversible vision loss. We developed and validated a multimodal, longitudin...

Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery

The genetic architecture of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness, remains largely unexplained due to the reli...

Identification of Risk Factors for Glaucoma Progression in Free-Text Clinical Notes using a Local Large Language Model

To evaluate the performance of a large language model (LLM) in identifying medication non-adherence, visit non-adherence, and family history of glauco...

A Federated Learning-based Optic Disc and Cup Segmentation Model for Glaucoma Monitoring In Color Fundus Photographs

Glaucoma, a leading cause of blindness worldwide, depends on accurate optic nerve head assessment, particularly optic disc and cup segmentation, for d...

Glaucoma Detection Using Deep Learning and Prompt-Based Explainable Report Generation

Glaucoma is a leading cause of irreversible blindness and requires early detection to prevent vision loss. This study proposes a novel framework for a...

Leveraging molecular-QTL co-association to predict novel disease-associated genetic loci using a graph convolutional neural network.

Genome-wide association studies (GWAS) have successfully uncovered numerous associations between genetic variants and disease traits to date. Yet, ide...

Jan 1 2025 40493586
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