Latest AI and machine learning research in heart transplantation for healthcare professionals.
BACKGROUND: Immune checkpoint molecules are pivotal regulators of immune activation and tolerance, playing critical roles in cancer, autoimmunity, infectious diseases, and transplantation. While programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) remain the most extensively studied checkpoints, immune checkpoint receptors beyond PD-1 and CTLA-4, includin...
UNLABELLED: Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key information for clinical decisions. A better understanding of the molecular mechanisms underlying PNI could lead to improved patient treatment strategies. Here, we generated whole-exome, whole-genome, and RNA sequencing data from tumors and matched nor...
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, primarily due to its low immunogenicity and immunosuppre...
Chen et al's research provides valuable data supporting the cautious use of transfusions during gastric cancer surgery. However, to interpret causalit...
While neutrophils represent a prominent myeloid component in non-small cell lung cancer (NSCLC), the specific immunosuppressive functions of N2-polari...
BACKGROUND: Tacrolimus is a first-line immunosuppressant essential for preventing graft rejection after liver transplantation, but its narrow therapeu...
Ovarian cancer (OC) ranks among the most aggressive malignancies of the female reproductive system. The immunosuppressive tumor microenvironment (TME)...
Breast cancer heterogeneity limits the precision of current prognostic and therapeutic strategies, underscoring the need for molecular frameworks that...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder in which aberrant B-cell activation, persistent autoantibody production, and...
Large Language Models (LLMs) with hundreds of billions of parameters have exhibited human-like intelligence by learning from vast amounts of internet-...
PURPOSE: Obesity is strongly associated with hepatocellular carcinoma (HCC), yet the molecular mechanisms linking them remain unclear. This study aime...
INTRODUCTION/AIMS: Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been...
OCCUPATIONAL APPLICATIONSThis pilot study demonstrates the feasibility of using EEG-derived features to characterize behavioral reliance among enginee...
BACKGROUND: There is an increasing amount of evidence on microbiome-drug interactions in several clinical settings, including in immunocompromised pat...
The ubiquitous use of plastics in modern society is accompanied by the pervasive occurrence of plastic pollution. Of particular concern are nanoplasti...
In order to address the tracking accuracy degradation of the tank gun control system (TGCS) with inherent structural nonlinearity and feedback hystere...
Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable success in hematologic malignancies but continues to face significant barriers ...
Glioblastoma (GB), the most aggressive primary brain tumor, is characterized by profound inter- and intratumoral heterogeneity and a highly immunosupp...
Therapeutic resistance remains the principal barrier to durable clinical benefit in oncology, particularly in oncogene-driven malignancies and immune-...
Electroencephalography (EEG)-based brain computer interface (BCI) systems hold significant promise across diverse applications; however, their perform...