Heart Transplantation

Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.

BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflammatory response during the IRI process. The objective of this study is to conduct an analysis of the developmental and differentiation characteristics ...

Transcriptome analysis reveals the potential role of neural factor EN1 for long-terms survival in estrogen receptor-independent breast cancer.

Breast cancer patients with estrogen receptor-negative (ERneg) status, encompassing triple negative breast cancer (TNBC) and human epidermal growth factor receptor 2 positive breast cancer, are confronted with a heightened risk of drug resistance, often leading to early recurrence; the biomarkers and biological processes associated with recurrence is still unclear. In this study, we analyzed bulk ...

Design and implementation of an independent-drive bionic dragonfly robot.

Bionic flapping wing robots achieve flight by imitating animal flapping wings, which are safe, flexible, and efficient. Their practicality and human-m...

Plant-inspired decentralized controller for robust orientation control of soft robotic manipulators.

Due to the complexity of deformations in soft manipulators, achieving precise control of their orientation is particularly challenging, especially in ...

Comparison of time-to-event machine learning models in predicting biliary complication and mortality rate in liver transplant patients.

Post-Liver transplantation (LT) survival rates stagnate, with biliary complications (BC) as a major cause of death. We analyzed longitudinal data with...

Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions.

Kidney transplantation is the definitive treatment for end-stage renal disease (ESRD), yet challenges persist in optimizing donor-recipient matching, ...

An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine.

Esophagitis is a frequent, but at the molecular level poorly characterized condition with diverse underlying etiologies and treatments. Correct diagno...

Modeling and control of a sperm-inspired robot with helical propulsion.

Efficient propulsion has been a central focus of research in the field of biomimetic underwater vehicles. Compared to the prevalent fish-like reciproc...

Machine learning and molecular subtyping reveal the impact of diverse patterns of cell death on the prognosis and treatment of hepatocellular carcinoma.

Programmed cell death (PCD) is a significant factor in the progression of hepatocellular carcinoma (HCC) and might serve as a crucial marker for predi...

Monkeypox diagnosis based on probabilistic K-nearest neighbors (PKNN) algorithm.

Although it is not a new illness and has been around since the previous century, monkeypox later resurgence is fraught with difficulties. This study p...

Assessing donor kidney function: the role of CIRBP in predicting delayed graft function post-transplant.

INTRODUCTION: Delayed graft function (DGF) shortens the survival time of transplanted kidneys and increases the risk of rejection. Current methods are...

Active Disturbance Rejection Control for an automotive suspension system based on parameter tuning using a fuzzy technique.

Road surface roughness is the cause of vehicle vibration, which is considered a system disturbance. Previous studies on suspension system control ofte...

Integrated RNA sequencing analysis and machine learning identifies a metabolism-related prognostic signature in clear cell renal cell carcinoma.

The connection between metabolic reprogramming and tumor progression has been demonstrated in an increasing number of researches. However, further res...

A deep learning approach to perform defect classification of freeze-dried product.

Cosmetic inspection of freeze-dried products is an important part of the post-manufacturing quality control process. Traditionally done by human visua...

Knowledge domain and frontier trends of artificial intelligence applied in solid organ transplantation: A visualization analysis.

BACKGROUND: Solid organ transplantation (SOT) is vital for end-stage organ failure but faces challenges like organ shortage and rejection. Artificial ...

Integrating immune multi-omics and machine learning to improve prognosis, immune landscape, and sensitivity to first- and second-line treatments for head and neck squamous cell carcinoma.

In recent years, immune checkpoint inhibitors (ICIs) has emerged as a fundamental component of the standard treatment regimen for patients with head a...

Unveiling the intricate interplay: Exploring biological bridges between renal ischemia-reperfusion injury and T cell-mediated immune rejection in kidney transplantation.

UNLABELLED: Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well kn...

Serum PD-1 regulation and PD-1 expression of CD4+Foxp3+ regulatory T cells in patients in thyroid eye disease associated with immunosuppression treatment.

PURPOSE: Thyroid eye disease (TED) primarily occurs in hyperthyroid patients, sometimes resulting in poor visual prognosis. Although other autoimmune ...

Using machine learning for personalized prediction of longitudinal coronavirus disease 2019 vaccine responses in transplant recipients.

The coronavirus disease 2019 pandemic has underscored the importance of vaccines, especially for immunocompromised populations like solid organ transp...

Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA sequencing and molecular docking.

Post-transplant allograft fibrosis remains a challenge in prolonging allograft survival. Regulated cell death has been widely implicated in various k...