Heart Transplantation

Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.

The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolving rapidly from the successful application of chimeric antigen receptor T (CAR-T) cells in hematologic malignancies to a multiplatform landscape characterized by the concurrent development of diverse strategies. Current research focuses on T cell re...

Metabolic reprogramming of myeloid cells in cancer: from lactate-NAMPT axis to AI-guided therapeutics.

Myeloid cells-including macrophages, monocytes, neutrophils and dendritic cells-are metabolically plastic sentinels that shape the tumor microenvironment. Among the myriad metabolites in cancer, lactate and nicotinamide adenine dinucleotide (NAD⁺) stand out as central coordinators of myeloid cell fate. Lactate accumulation, driven by tumor glycolysis, profoundly reprograms myeloid metabolism throu...

OracleScreen-LILRB4: machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells.

The identification of small molecule modulators of immune checkpoint proteins remains a significant challenge in drug discovery due to the flat, featu...

Mapping the intellectual landscape of malaria drug repurposing: a systematic analysis of the 51 most cited studies.

BACKGROUND: The escalating threat of Plasmodium falciparum resistance to artemisinin-based therapies necessitates accelerated drug development. Drug r...

Genomic scale analysis of assembly-line polyketide synthase diversity and evolution.

Covering: up to 2026Assembly-line polyketide synthases (PKSs) are among the most sophisticated catalysts in nature, responsible for the biosynthesis o...

Multidrug resistance in cancer: current understandings and future perspective.

Multidrug resistance (MDR) remains the core clinical barrier limiting the achievement of durable and effective treatment for various tumors. With the ...

Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer.

BACKGROUND: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain lar...

Immunosuppressive regimens and long-term kidney transplant outcomes: A dual survival modeling framework.

Optimizing immunosuppressive therapy remains central to improving long-term outcomes after kidney transplantation. Both induction and maintenance ther...

Integrated single-cell RNA sequencing and Bulk-RNA technologies reveal the immunological characteristics of lactylation related-genes in glioblastoma.

OBJECTIVE: Glioblastoma (GBM) is the most aggressive type of intracranial malignant tumor, known for its extremely poor prognosis. Lactylation, a newl...

Data-driven design of hybrid graphene oxide-MXene polymeric membranes for water purification.

Two-dimensional (2D) materials offer promising platforms for water purification, particularly for challenging oil-in-water emulsions. Here, a hybrid m...

A novel model (SED-GNDE) integrating graph neural differential equations with selective electrodialysis process for nutrient prediction from synthetic wastewater.

Selective electrodialysis (SED) is a promising method for recovering nutrient ions, such as phosphate, ammonium, sulfate and potassium, from wastewate...

IL4Rα blockade inhibits proliferation of malignant lymphocytes and the immunosuppressive tumor microenvironment of mycosis fungoides.

BACKGROUND: Limited therapeutic options are available for patients with advanced-stage mycosis fungoides (MF), and the 5-year survival rate is 25%. Du...

Molecular characteristics and modifications of glioblastoma affecting the efficacy of immunotherapy.

Glioblastoma is a highly aggressive brain tumor characterized by complex genetic, molecular, and epigenetic features that present significant challeng...

A self-orchestrating physics-discovering neural architecture for adaptive and fault-resilient robotic motion control via RPA and digital twins.

To autonomously control a robot's movement in complex and unpredictable environments, adaptive models must be developed that can continuously learn ab...

Engineered Neutrophils in Translational Medicine: Gene Editing, Nanotechnology, and AI-Driven Clinical Breakthroughs.

Engineered neutrophils, modified via advanced biotechnological tools, are emerging as pivotal agents in translational medicine. By integrating gene ed...

Integrative multi-omics analysis and machine learning identify M2 macrophage-induced ferroptosis resistance in glioblastoma.

Glioblastoma (GBM) is characterized by profound intratumoral heterogeneity and an immunosuppressive microenvironment that drive therapeutic resistance...

Barriers and enablers for publishing results of randomized trials: a cross-sectional survey of principal investigators in sub-Saharan Africa.

OBJECTIVES: To investigate the views and experiences of principal investigators (PIs) based in sub-Saharan Africa (SSA) regarding publication bias of ...

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.

BACKGROUND: Immunotherapy has shown limited efficacy in a substantial subset of CRC patients, yet the mechanisms underlying therapeutic resistance rem...

Multi-Omics Analysis Identifies Paxillin as a Biomarker of Doxorubicin Resistance via Cytoskeletal Remodeling and Immune Exhaustion.

Chemotherapy resistance remains a primary cause of treatment failure in breast cancer, yet the global proteomic landscape driving this phenotype has n...

Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients.

BACKGROUND: Donor-specific antibodies (DSA) against human leukocyte antigens (HLA) are associated with increased immunologic risk in kidney transplant...