Heart Transplantation

Single-cell and spatial transcriptomic landscapes reveal PIGT as a pivotal regulator of immunometabolic remodeling in colorectal cancer liver metastasis.

Colorectal cancer liver metastasis (CRLM) represents the leading cause of mortality in colorectal cancer (CRC). However, the molecular mechanisms enabling metastatic adaptation within the hepatic microenvironment remain unclear. We integrated single-cell RNA sequencing, spatial transcriptomics, and bulk transcriptomic data from CRC patients to characterize the immunometabolic landscape of CRLM. Ma...

Artificial intelligence predicts recurrent autoimmune hepatitis after liver transplantation in a multicenter cohort study.

BACKGROUND: Autoimmune hepatitis (AIH) is an important indication for liver transplantation (LT), but recurrence affects over 30% of recipients, threatening long-term survival. Current strategies to prevent recurrence and progressive graft fibrosis remain suboptimal, with limited evidence to guide selection of immunosuppressive regimens. We aimed to develop a dynamic, individualized, artificial in...

Retinal Pigment Epithelium and Microglia Transplantation in Age-related Macular Degeneration.

Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, characterized by the progressive breakdown of the ...

The single-cell atlas of programmed cell death signature: A machine learning-based prognostic framework in breast cancer.

Breast cancer remains a leading cause of cancer-related mortality in women, and current prognostic models are suboptimal. The transcriptomic role of p...

Can large language models provide high-quality desk review decisions in an orthopaedic surgery journal? A concordance study comparing three AI models to human editorial decisions.

BACKGROUND: Artificial intelligence (AI) is increasingly integrated into scientific publishing workflows, yet no study has formally evaluated the abil...

Single-cell and spatial transcriptomics reveal SUV39H1 as a master epigenetic driver of immunosuppressive niche and stemness in bladder cancer.

Bladder cancer (BC) exhibits profound molecular heterogeneity and a highly dynamic tumor microenvironment, posing major challenges for effective thera...

Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics.

Despite advancements in therapeutic cancer vaccines, clinical translation has been hindered by limited efficacy, with Sipuleucel-T remaining the only ...

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 ...

Keratin gene expression signature predicts prognosis and immunotherapy efficacy in lung adenocarcinoma.

Keratins (KRTs) are intermediate filament proteins expressed in epithelial cells and serve as diagnostic cancer biomarkers. They serve pivotal roles i...

Recent Advances in Immunotherapy for Breast Cancer: An Updated Review.

Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-negative breast cancer (TNBC), yet primary and acqu...

Enhancing the performance of diabetic retinopathy grading models using synthetic images.

PURPOSE: To determine whether strictly curated synthetic images can improve grading performance in diabetic retinopathy (DR) diagnosis within limited ...

Identification and analysis of EphrinB2/EphB4 signaling pathway and angiogenesis related biomarkers in coronary artery disease based on bioinformatics.

BACKGROUND: EphrinB2 and its receptor EphB4 have been reported to play a crucial role in the development of the cardiovascular system, and the process...

Quantifying Artificial Intelligence Contribution in Academic Writing: Development of the Transparency and Reporting of Artificial Intelligence Contribution for Evaluating Submissions Instrument.

BACKGROUND: There has been an increase in the availability and use of artificial intelligence (AI) across many professional domains, and there are tra...

Identification of Microbiome Associations with Tacrolimus Pharmacokinetics in Adult Hematopoietic Cell Transplantation Using Population Pharmacokinetic and Machine Learning.

PURPOSE: Tacrolimus (TAC) is known for its high pharmacokinetic variability which cannot be fully explained by pharmacogenomic (PGx) and clinical vari...

Hypoxia tumor-associated macrophages facilitate hepatocellular carcinoma metastasis via uPA-uPAR pathway.

BACKGROUND: Hepatocellular carcinoma (HCC) arises within a hypoxic and immunosuppressive tumor microenvironment (TME), where tumor-associated macropha...

Neoadjuvant Chemoradiotherapy on Postoperative Complications of Rectal Cancer: A Retrospective Study Integrating MRI Radiomics and Deep Learning.

Neoadjuvant chemoradiotherapy (nCRT) is standard for locally advanced rectal cancer but increases postoperative complication (POC) risks due to tissue...

Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.

The therapeutic landscape of colorectal cancer (CRC) has evolved with the identification of molecular subtypes, including mismatch repair-deficient/mi...

Atomic Uncertainty Pinpoints Critical Failure Structures for Trustworthy Molecular Property Prediction.

Accurate prediction of molecular properties is essential for accelerating drug discovery, yet current deep learning methods generally lack reliable un...

Activated Cancer-Associated Fibroblasts Are Associated with Immunosuppression and Poor Prognosis in Clear Cell Renal Cell Carcinoma.

INTRODUCTION: Clear cell renal cell carcinoma (ccRCC) exhibits substantial heterogeneity within its tumor microenvironment, contributing to variable c...

MAPPING THE MTOR PATHWAY IN LUNG TRANSPLANTATION: IS IT TIME FOR A BIOMARKER-DRIVEN PRECISION THERAPY?

Solid organ transplantation has revolutionized the treatment of end-stage diseases, yet long-term graft survival remains constrained by immune-mediate...