Heart Transplantation

Spatial multi-omics identify an immunosuppressive lipid-laden macrophage niche in primary CNS lymphoma

Primary central nervous system lymphoma (PCNSL) is a subtype of diffuse large B-cell lymphoma (DLBCL) with confined CNS growth. We evaluated tumor microenvironment (TME) features associated with its unique tropism. Comparative spatial transcriptomic profiling of PCNSL samples (n=17) revealed increased macrophage infiltration compared to systemic DLBCL (n=76). These macrophages showed enrichment of...

Single center Automated, Multi-Source deeply Phenotyped Heart Transplant Registry as a template to build tailored data infrastructure

Background: Traditional heart transplant registries often lack the granularity required for deep phenotyping and rely on labor-intensive manual abstraction. We describe the methodology and validation of a next-generation, automated, multi-source registry designed to address these limitations. Methods: Utilizing a High-Performance Computing environment, we integrated structured data from Epic data ...

Latent Neural-ODE for Model-Informed Precision Dosing: Overcoming Structural Assumptions in Pharmacokinetics

Accurate estimation of tacrolimus exposure, quantified by the area under the concentration-time curve (AUC), is essential for precision dosing after r...

EarResp-ANS : Audio-Based On-Device Respiration Rate Estimation on Earphones with Adaptive Noise Suppression

Respiratory rate (RR) is a key vital sign for clinical assessment and mental well-being, yet it is rarely monitored in everyday life due to the lack o...

Reformulating AI-based Multi-Object Relative State Estimation for Aleatoric Uncertainty-based Outlier Rejection of Partial Measurements

Precise localization with respect to a set of objects of interest enables mobile robots to perform various tasks. With the rise of edge devices capabl...

Noise-Robust Contrastive Learning with an MFCC-Conformer For Coronary Artery Disease Detection

Cardiovascular diseases (CVD) are the leading cause of death worldwide, with coronary artery disease (CAD) comprising the largest subcategory of CVDs....

Pharmacogenomic Determinants of Post-Liver Transplant Diabetes Mellitus: A Systematic Review and In Silico Pharmacogenomic Analysis

Introduction: Tacrolimus remains central to liver transplantation, yet its narrow therapeutic index and pharmacokinetic variability are associated wit...

Drastic changes in collaboration networks and publication patterns in research using the CDC WONDER dataset

The growth of generative AI and easily available Open Access health datasets has transformed researcher productivity, leading to an explosion in publi...

High-dimensional spatial proteomics and novel machine learning pipeline identifies disease specific renal damage states

Lupus nephritis (LuN) and renal allograft rejection (RAR) manifest inflammation and fibrosis that ultimately lead to kidney failure. To quantitatively...

Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.

Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs)...

Blended cellulose nitrate/cellulose acetate membranes for enhanced water treatment performance in ultrafiltration.

The utilization of cellulose derivatives offers an eco-friendly alternative to petroleum-based polymers, necessitating research into effective water p...

Improving the Reasoning of Multi-Image Grounding in MLLMs via Reinforcement Learning

Recently, Multimodal Large Language Models (MLLMs) excel at visual grounding in single-image scenarios with textual references. However, their perfo...

Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects.

Cellular senescence is a complex biological process with a dual role in tissue homeostasis and aging-related pathologies. Accumulation of senescent ce...

Deep learning-based histopathologic segmentation of peritubular capillaries in kidney transplant biopsies.

BACKGROUND: Assessing the extent of inflammation in peritubular capillaries (PTCs) is important for diagnosing antibody-mediated rejection in kidney t...

DFT-assisted machine learning for polyester membrane design in textile wastewater recovery applications.

Resource recovery from textile wastewater has attracted increasing interest because it simultaneously addresses wastewater treatment and maximizes the...

SABRE-FL: Selective and Accurate Backdoor Rejection for Federated Prompt Learning

Federated Prompt Learning has emerged as a communication-efficient and privacy-preserving paradigm for adapting large vision-language models like CL...

Personalized translational medicine: Investigating YKL-40 as early biomarker for clinical risk stratification in hepatocellular carcinoma recurrence post-liver transplantation.

Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) presents a significant challenge, with recurrence rates ranging from 8% to ...

Online-Optimized Gated Radial Basis Function Neural Network-Based Adaptive Control

Real-time adaptive control of nonlinear systems with unknown dynamics and time-varying disturbances demands precise modeling and robust parameter ad...

Reinforcing Spatial Reasoning in Vision-Language Models with Interwoven Thinking and Visual Drawing

As textual reasoning with large language models (LLMs) has advanced significantly, there has been growing interest in enhancing the multimodal reaso...

Evidential Deep Learning with Spectral-Spatial Uncertainty Disentanglement for Open-Set Hyperspectral Domain Generalization

Open-set domain generalization(OSDG) for hyperspectral image classification presents significant challenges due to the presence of unknown classes i...