Latest AI and machine learning research in heart transplantation for healthcare professionals.
T-cell bispecific antibodies (TCBs), a specialized subclass of bispecific antibodies (BsAbs), are engineered to simultaneously engage T cells and tumor cells by binding two distinct antigens-or two epitopes on a single antigen-thereby redirecting cytotoxic T lymphocytes to eliminate malignant cells. These agents enhance anti-tumor immunity through dual mechanisms: direct activation of T cell recep...
Organ transplantation remains a gold-standard intervention for numerous end-stage organ failure diseases. However, allograft rejection is still a barrier to long-term graft survival. Conventional allograft monitoring approaches, including tissue biopsies and functional evaluations, are constrained by their invasiveness, limited specificity, and time-consuming nature. Biosensor platforms have emerg...
Cancer-associated fibroblasts (CAFs) are major stromal components of the tumor microenvironment (TME) and play diverse roles in gastrointestinal (GI) ...
BACKGROUND: Ammonia, which was traditionally regarded as a metabolic by-product, has more recently emerged as a crucial regulator of tumor metabolism ...
PURPOSE OF REVIEW: Asthma continues to pose a serious global health issue affecting billions of people and causing significant morbidity. It is immuno...
BACKGROUND: Thyroid carcinoma (TC) presents a rising global incidence, with a subset of cases progressing aggressively despite standard therapies. The...
Cyclosporine A (CsA) functions as a calcineurin inhibitor that perturbs T cell activation via calcineurin-nuclear factor of activated T cells (CaN-NFA...
BACKGROUND: Acute myeloid leukemia (AML) remains a therapeutic challenge due to chemoresistance and immunosuppression. This study aimed to discover no...
BACKGROUND: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high recurrence and limited therapies. Microvascular invasion (MVI) is a...
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive subtype of primary liver cancer with insidious onset, early metastasis, and p...
Streptomyces are renowned for their unparalleled capacity to produce bioactive natural products, making them prime candidates for industrial antibioti...
The dicentric chromosome assay (DCA) serves as the gold standard for quantifying ionising radiation exposure in individuals. However, the conventional...
Cancer immunotherapy has revolutionised oncology by utilising immune-mediated mechanisms to achieve durable anti-tumour responses and long-term clinic...
Artificial intelligence (AI) has emerged as a transformative force in liver transplantation (LT), spanning patient selection, donor-recipient matching...
INTRODUCTION/BACKGROUND: To determine whether a prompting-based, interpretable artificial intelligence (AI) system, specifically a large language mode...
Despite thorough characterizations of cellular compositions within the breast tumor microenvironment (TME), their implications for disease progression...
High-frequency oscillations (HFOs), transient burst of ≥ 80 Hz activity, are increasingly recognized as promising EEG biomarkers of the epileptogenic ...
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis and variable response to therapy. E...
BACKGROUND: Mitochondrial metabolism (MM) abnormalities have been implicated in multiple diseases, but its contribution to sepsis-associated encephalo...
Unmanned Aerial Vehicles (UAVs) equipped with robotic manipulators have emerged as a powerful paradigm for advanced aerial manipulation tasks, includi...