Latest AI and machine learning research in heart transplantation for healthcare professionals.
BACKGROUND: The peer review system faces increasing strain from rising manuscript volumes, reviewer fatigue, and well-documented interreviewer disagreement. Large language models (LLMs) have shown potential to support the peer review process, but their ability to replicate editorial decisions at high-impact medical journals and their utility as manuscript screening tools remain unknown. PURPOSE: T...
BACKGROUND: To identify serum metabolic biomarkers that distinguish corticosteroid and cyclosporin A (CS & CsA) resistant pediatric idiopathic uveitis (PIU) patients from sensitive counterparts. METHODS: Serum samples were collected from 32 CS & CsA-sensitive PIU patients and 24 CS & CsA-resistant PIU patients, respectively. UHPLC-OE-MS was employed for comprehensive metabolic profiling of the ser...
Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to ...
Triple-negative breast cancer (TNBC) is classified as an immunologically cold tumor, which markedly weakens the therapeutic efficacy of immune checkpo...
Glioblastoma presents a significant challenge for drug development due to its complex immunosuppressive microenvironment. Identifying candidate therap...
BACKGROUND: Metabolic reprogramming represents a hallmark feature of hepatocellular carcinoma (HCC). As a crucial branch of the polyol pathway, the bi...
INTRODUCTION: Radiographic image quality is evaluated based on technical and anatomical criteria; however, this study investigates how radiographers i...
BACKGROUND: Integrating machine learning (ML) with population pharmacokinetic (PPK) modeling may improve therapeutic drug monitoring predictions. METH...
The poor prognosis of high‑grade gliomas, such as glioblastoma, is largely driven by a notably immunosuppressive tumor microenvironment (TME), wherein...
Emerging evidence indicates that aberrant cholesterol metabolism in macrophages plays a role in tumorigenesis, however, how specific metabolites relea...
Oncolytic viruses (OVs) represent a versatile platform for cancer immunotherapy, capable of selectively infecting and lysing tumor cells while trigger...
Mild traumatic brain injury (mTBI) frequently prompts computed tomography (CT) imaging in emergency departments, despite a high proportion of negative...
Tumor heterogeneity remains a major barrier to effective cancer therapy, driving the need for novel biomarkers and targeted strategies. A bibliometric...
Oral leukoplakia (OLK) is the most common oral potentially malignant disorder and carries a lifetime risk of transformation to oral squamous cell carc...
Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct clinicopatholog...
The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolv...
Myeloid cells-including macrophages, monocytes, neutrophils and dendritic cells-are metabolically plastic sentinels that shape the tumor microenvironm...
Mineral and bone disease (MBD) is a frequent complication after solid organ transplantation. The rapid decline in bone mineral density (BMD) during th...
The identification of small molecule modulators of immune checkpoint proteins remains a significant challenge in drug discovery due to the flat, featu...
BACKGROUND: The escalating threat of Plasmodium falciparum resistance to artemisinin-based therapies necessitates accelerated drug development. Drug r...