Heart Transplantation

Human-AI Interaction in Kidney Transplant Decision Support Systems: Qualitative Study of Patient and Support Person Expectations.

BACKGROUND: Artificial intelligence (AI) is increasingly applied in medicine, including clinical decision-making. AI-based decision support systems (DSS) can enhance early risk detection and treatment optimization. However, the perspectives of patients and their support persons on AI-assisted DSS in clinical care, particularly regarding shared decision-making (SDM), remain underexplored. OBJECTIVE...

PFAS is associated with perineural invasion in triple-negative breast cancer with a potential role for Cathepsin D dysregulation: a multi-omics and experimental study.

Per- and polyfluoroalkyl substances (PFAS) are persistent pollutants linked to breast cancer (BC), but their role in perineural invasion (PNI) of triple-negative breast cancer (TNBC) is unclear. Cathepsin D (CTSD), a lysosomal protease, is hypothesized to mediate PFAS-induced PNI, though systematic evidence is lacking. We integrated multi-omics data from TCGA-BRCA, METABRIC, and single-cell RNA-se...

Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation.

G protein-coupled receptors (GPCRs) serve as central hubs in tumor signal transduction and microenvironment regulation. However, their therapeutic exp...

Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study.

BACKGROUND: The clinical value of artificial intelligence (AI)-based diagnostic systems depends not only on their accuracy but also on how well their ...

Prospects and Challenges of Personalized Immunotherapy in Breast Cancer Treatment and Long-term Cancer Management.

Breast cancer is highly heterogeneous,and different molecular subtypes exhibit significant variations in their response to immunotherapy.While signifi...

Multimodal Artificial Intelligence for Early Detection and Precision Management of Inflammatory and Infiltrative Cardiomyopathies.

BACKGROUND: Inflammatory and infiltrative cardiomyopathies, including cardiac sarcoidosis, transthyretin amyloidosis, and autoimmune myocarditis, are ...

Synthetic Inducible Bacteria Normalize the Microenvironment of Refractory Tumors, Potentiating Checkpoint Inhibitor Responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

CSCAN: Conformational Analysis of Macrocyclic Peptides through NMR Chemical Shifts.

Macrocyclic peptides are increasingly used to bridge the gap between small molecules and biologics. Their biological activity and pharmacological prop...

Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism.

The discovery of selective immunosuppressants for T cell-mediated diseases like Ulcerative Colitis (UC) is a significant challenge. While traditional ...

Integrative multi-omics analysis identifies a core ferroptosis signature and validates resveratrol as a novel inducer in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to treatment resistance and an immunosuppressive, fibrotic microenvironment. Ferrop...

Integrating spatial and single-cell transcriptomics via machine learning to characterize efferocytosis in hepatocellular carcinoma prognosis and immunotherapy.

BACKGROUND: The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic ef...

Immunological Drug-Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence.

PURPOSE OF REVIEW: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, producing durable responses across multiple malignancies. Howe...

Neuro-Adaptive Integral Sliding-Mode Consensus Control for Multi-ASVs With Unknown Nonlinearity via Dissipative Disturbance Estimation.

This article investigates a dissipative disturbance-estimator (DDE)-based neuro-adaptive integral sliding-mode control (ISMC) for multiple autonomous ...

Single-cell and machine learning reveal ROS-associated heterogeneity in hepatocellular carcinoma for precision medicine.

BACKGROUND: Reactive oxygen species (ROS) are critical regulators of tumor development and progression, yet their clinical significance and cellular m...

Hemovigilance in a Brazilian Amazon blood center: A temporal analysis of 5-year consumption patterns.

BACKGROUND: The transfusion of blood components remains a cornerstone in the management of hematological and onco-hematological diseases. Effective bl...

Single-cell and deep learning identify hypoxia-responsive lncRNAs predicting outcomes in colorectal cancer.

Emerging evidence highlights hypoxia-responsive long non-coding RNAs (lncRNAs) as potential modulators in tumor biology. In this study, we explored th...

Copper transporters promote the malignant progression of glioblastoma by regulating the immunosuppressive tumour microenvironment via the SLC31A1-WNT5A axis.

BACKGROUND: The prognosis for patients with glioblastoma (GBM) remains extremely poor, a challenge largely attributable to the complex nature of its m...

Involved nodal versus elective neck radiotherapy (INVERT) for head and neck squamous cell carcinoma: a prospective phase II randomized controlled trial protocol.

BACKGROUND: Definitive chemoradiotherapy for head and neck squamous cell carcinomas (HNSCC) carries significant long-term toxicities, with elective ne...

Screening of Sepsis Diagnostic Biomarkers Based on Fumarate Metabolism-Related Genes with Analysis of Immune Infiltration and Subtype Identification.

BACKGROUND: Sepsis is a major global health challenge characterized by a complex pathogenesis involving an early hyperinflammatory phase followed by a...

Characterization of telomere-related gene subtypes in lung adenocarcinoma and their implications for prognosis and treatment.

BACKGROUND: Telomeres, located at chromosome ends, regulate cell division and maintain genomic stability. Telomere-related genes (TRGs) play essential...