Heart Transplantation

Single-cell profiling identifies a pro-tumoral VCAN positive macrophage subset and defines a prognostic signature in glioblastoma.

Glioblastoma (GBM), the most aggressive primary brain tumor, develops within a tumor microenvironment (TME) dominated by tumor-associated macrophages (TAMs) that critically influence disease progression. Through single-cell RNA sequencing (scRNA-seq) and bioinformatic analysis, we delineated macrophage heterogeneity within the GBM TME and identified a distinct VCAN⁺ macrophage subpopulation. Pseud...

Integrating machine learning and single-cell sequencing to reveal the role of kinase-related genes in subtype classification and prognostic significance of lung squamous cell carcinoma.

BACKGROUND: Lung squamous cell carcinoma (LUSC) exhibits poor prognosis and a highly complex tumor immune microenvironment (TIME), creating an urgent clinical need for novel biomarkers to guide personalized treatment. Although kinase-related genes (KRGs) play a central role in signal transduction and malignant progression across multiple tumors, large-scale systematic exploration of KRGs' regulato...

A fully automated framework for acoustic identification and localization of terrestrial wildlife at scale.

Autonomous acoustic recorders are increasingly important tools for monitoring sound-producing taxa. Coupled with advances in machine learning, they en...

Modulation of tumor-derived exosomes and reprogramming of cancer-associated fibroblasts for colorectal cancer therapy.

Hypoxia is pervasive within the solid tumor microenvironment (TME), reshaping it through exosome release. As the main component of the tumor stroma, f...

Multidimensional immune ecological subtyping identifies RUNX1 as a prognostic factor in uveal melanoma.

Uveal melanoma (UVM) is an aggressive intraocular malignancy with a high risk of metastasis but few effective therapies. However, current molecular cl...

Early identification of high-risk individuals for mortality after lung transplantation: A retrospective cohort study with topological feature engineering.

Lung transplantation remains the only definitive treatment for end-stage respiratory failure; however, it has substantial post-operative mortality ris...

Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges.

Immunotherapy has long played a pivotal role in cancer treatment, and antigen-presenting cell (APC)-based immunotherapy represents a promising strateg...

A prognostic model based on nucleotide metabolism genes in osteosarcoma.

Osteosarcoma typically arises during adolescence, posing a significant challenge. Despite comprehensive treatment strategies encompassing surgery, rad...

An Integrated Clinical-Histopathologic Prediction Model for Cardiac Allograft Rejection: Translating Machine Learning into Clinical Risk Frameworks.

BACKGROUND: Cardiac allograft rejection (CAR) remains the leading cause of early graft failure after heart transplantation (HT). Current diagnostics, ...

Synthetic inducible bacteria normalize the microenvironment of refractory tumors, potentiating checkpoint inhibitor responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

Mechanistic Insights into PFAS Rejection in Nanofiltration and Reverse Osmosis from Data-Driven Analysis.

The structural diversity and complex transport behavior of per- and polyfluoroalkyl substances (PFAS) complicate a universal characterization of their...

Neural Stem Cell-Derived Extracellular Vesicles: The Next Frontier in Neurological and Neurodegenerative Diseases.

The present manuscript provides a comprehensive overview of neural stem cell (NSC)-derived extracellular vesicles (NSC-EVs( as a cell-free approach to...

Integrated cross-organ transcriptomic analysis uncovers conserved gene signatures predictive of allograft rejection.

Long-term transplant success is limited by allograft rejection, a complex process traditionally studied on an organ-specific basis. To establish a uni...

Resolving the ambiguous binding site of quercetin at the calcineurin subunit junction using funnel metadynamics with deep learning collective variables.

Calcineurin represents a prominent target for immunosuppressive drugs, where conventional macrocyclic inhibitors utilize an immunophilin-dependent mec...

Beyond HLA-Ia: A multidimensional framework for Neoantigen immunotherapy.

Glioblastoma (GBM) and other malignant gliomas are associated with aggressive progression, high recurrence rates, and poor long-term outcomes, while c...

A machine learning-driven framework integrating cell death and senescence signatures for multi-target drug design and immunotherapy optimization in ovarian cancer.

Ovarian cancer (OC) remains therapeutic challenge due to its complex molecular heterogeneity and therapy-induced adaptive resistance. While non-apopto...

A macrophage co-expression signature enables robust prognostic prediction in glioblastoma.

BACKGROUND: Glioblastoma (GBM) exhibits profound cellular heterogeneity and a highly immunosuppressive microenvironment in which tumor-associated macr...

Optimizing Ternary Preparation Parameters of Thin-Film Nanocomposite Membranes for Tailored Selectivity via Interpretable Machine Learning.

Novel thin-film nanocomposite (TFN) nanofiltration membranes have attracted wide attention for their generally boosted water permeability. However, th...

Heterogeneity of depression and suicidal ideation among college students in Eastern China: a latent profile analysis and machine learning approach.

To investigate the heterogeneity of depression and suicidal ideation among Chinese college students and to examine the roles of family and individual ...

Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Alt...