Hematology

Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability.

BACKGROUND AND OBJECTIVE: Eltrombopag is the first oral, small-molecule, non-peptide thrombopoietin receptor agonist for the treatment of idiopathic thrombocytopenic purpura. This study investigated the pharmacokinetics of eltrombopag in healthy Chinese subjects and evaluated the effect of sex and genetic polymorphisms on its variability.

A comparison of surgical outcomes among robotic cases performed with an employed surgical assist versus a second surgeon as the assist.

To examine whether utilizing an employed surgical first assistant or a physician as an assistant during gynecologic robotic cases affects surgical variables. A high volume gynecologic oncologist's robotic case data spanning fourteen years (2005-2018) was analyzed. We separated the cases based on the type of assistant used: either an employed surgical first assist or another physician. The assistin...

Robotic infant surgery with 3 mm instruments: a study in piglets of less than 10 kg body weight.

No data exist concerning the appication of a new robotic system with 3 mm instruments (Senhance®, Transenterix) in infants and small children. Therefo...

Management of Significant Airway Bleeding during Robotic Assisted Bronchoscopy: A Tailored Approach.

Robotic assisted bronchoscopy represents a major turning point in bronchoscopic history. The management strategies to address significant airway bleed...

Blood Pressure Morphology Assessment from Photoplethysmogram and Demographic Information Using Deep Learning with Attention Mechanism.

Arterial blood pressure (ABP) is an important vital sign from which it can be extracted valuable information about the subject's health. After studyin...

AIDeveloper: Deep Learning Image Classification in Life Science and Beyond.

Artificial intelligence (AI)-based image analysis has increased drastically in recent years. However, all applications use individual solutions, highl...

Fast and efficient retinal blood vessel segmentation method based on deep learning network.

The segmentation of the retinal vascular tree presents a major step for detecting ocular pathologies. The clinical context expects higher segmentation...

Artificial Intelligence Applied to the Rapid Identification of New Antimalarial Candidates with Dual-Stage Activity.

Increasing reports of multidrug-resistant malaria parasites urge the discovery of new effective drugs with different chemical scaffolds. Protein kinas...

Deep Transfer Learning for Automated Intestinal Bleeding Detection in Capsule Endoscopy Imaging.

PURPOSE: The objective of this paper was to develop a computer-aided diagnostic (CAD) tools for automated analysis of capsule endoscopic (CE) images, ...

Rapid analysis of streaming platelet images by semi-unsupervised learning.

We developed a fast and accurate deep learning approach employing a semi-unsupervised learning system (SULS) for capturing the real-time noisy, sparse...

The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?

Microglia performs a variety of functions during brain development designed to maintain brain homeostasis. Triggering receptor expressed on myeloid ce...

The effect of diabetes on major robotic hepatectomy.

Studies regarding the influence of diabetes on perioperative outcomes after major hepatectomy are conflicting. The objective of this study is to analy...

Classification of red blood cell aggregation using empirical wavelet transform analysis of ultrasonic radiofrequency echo signals.

Grading red blood cell (RBC) aggregation is important for the early diagnosis and prevention of related diseases such as ischemic cardio-cerebrovascul...

Reduction of quantitative systems pharmacology models using artificial neural networks.

Quantitative systems pharmacology models are often highly complex and not amenable to further simulation and/or estimation analyses. Model-order reduc...

Trends in application of advancing computational approaches in GPCR ligand discovery.

G protein-coupled receptors (GPCRs) comprise the most important superfamily of protein targets in current ligand discovery and drug development. GPCRs...

Protein glycation - biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine.

Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA (A1C). It is a biomarker for diagnosis of diabetes and pred...

An inguinal hernia that arose after robot-assisted radical prostatectomy and the repair of an intraoperative external iliac vein injury: A case report.

This case involved a 63-year-old man. He underwent robot-assisted radical prostatectomy (RARP) for prostate cancer. One year after the operation, he c...

Artificial intelligence supported anemia control system (AISACS) to prevent anemia in maintenance hemodialysis patients.

Anemia, for which erythropoiesis-stimulating agents (ESAs) and iron supplements (ISs) are used as preventive measures, presents important difficulties...

Propensity matched analysis of short term oncological and perioperative outcomes following robotic and thoracolaparoscopic esophagectomy for carcinoma esophagus- the first Indian experience.

Thoracolaparoscopic esophagectomy (TLE) for carcinoma esophagus has better short-term outcomes compared to open esophagectomy. The precise role of rob...

Improving blood cells classification in peripheral blood smears using enhanced incremental training.

Peripheral Blood Smear (PBS) analysis is a vital routine test carried out by medical specialists to assess some health aspects of individuals. The aut...