Hematology

Latest AI and machine learning research in hematology for healthcare professionals.

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Predicting how perturbations reshape cellular trajectories with PerturbGen

A major challenge in biology is predicting how cells transition between states over time and how perturbations disrupt these transitions. Understanding such dynamics is critical for identifying interventions that reverse pathological programs or reprogram cells toward desired states. Although recent computational approaches can predict single-cell perturbation responses in silico, they cannot pred...

Uncertainty-aware Blood Glucose Prediction from Continuous Glucose Monitoring Data

In this work, we investigate uncertainty-aware neural network models for blood glucose prediction and adverse glycemic event identification in Type 1 diabetes. We consider three families of sequence models based on LSTM, GRU, and Transformer architectures, with uncertainty quantification enabled by either Monte Carlo dropout or through evidential output layers compatible with Deep Evidential Regre...

Mar 5 2026 2603.04955v1
Early treatment outcome prediction in metastatic castration-resistant prostate cancer utilizing 3-month tumor growth rate (g-rate) based machine learning model

Summary Background Once the treatment starts, early prediction of treatment benefit and its correlation with overall survival (OS) remains challenging...

Beyond Language Modeling: An Exploration of Multimodal Pretraining

The visual world offers a critical axis for advancing foundation models beyond language. Despite growing interest in this direction, the design space ...

Mar 3 2026 2603.03276v1
COOL-MC: Verifying and Explaining RL Policies for Platelet Inventory Management

Platelets expire within five days. Blood banks face uncertain daily demand and must balance ordering decisions between costly wastage from overstockin...

Mar 2 2026 2603.02396v1
Robust White Blood Cell Classification with Stain-Normalized Decoupled Learning and Ensembling

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monit...

Mar 2 2026 2603.01976v1
Parkinson's Disease motor and non-motor progression models emerge from pathway-level transcriptomics

Background Prognosis and therapeutic management in Parkinson's disease is a challenging task by its highly heterogeneous disease progression and sympt...

Onco-Shikshak: An AI-Native Adaptive Learning Ecosystem for Medical Oncology Education

Medical oncology education faces a dual crisis: knowledge velocity that outpaces static curricula and large language model (LLM) risks hallucination a...

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

Objective: Electronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet...

p-Brain: An Automated MRI Pipeline for Cerebral Perfusion, Microvasculature, and Blood-Brain Barrier Permeability Estimation

We present p-Brain, an end-to-end neuroimaging analysis framework for reproducible, automated quantitative DCE-MRI analysis at scale. From standard ac...

Multi-Model Clinical Validation of an AI-Powered Biomarker Analysis Framework: A Cross-Vendor Benchmark on 4,018 NHANES Patients

Background: Large language models (LLMs) show promise for clinical decision support, yet most validation studies evaluate single models, leaving quest...

Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies

Recent advances in machine learning (ML)-based protein design methods have enabled the rapid in silico generation of large libraries of miniprotein bi...

A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis

Aging of hematopoietic stem and progenitor cells (HSPCs) impairs regenerative capacity and predisposes to hematological diseases. Here, we constructed...

A custom phenotypic profile for Fanconi anemia: Addressing gaps in existing disease annotations

Fanconi anemia (FA) is a rare genetic disorder of impaired DNA repair characterized by progressive bone marrow failure, congenital malformations, and ...

AI-Driven Clinical Decision Support System for Enhanced Diabetes Diagnosis and Management

Identifying type 2 diabetes mellitus can be challenging, particularly for primary care physicians. Clinical decision support systems incorporating art...

Feb 11 2026 2602.11237v1
Predicting Obstetric and Non-obstetric Diagnoses Co-occurrences during Pregnancy

Pregnancy care often involves simultaneous obstetric and other medical conditions, but their co-occurrence patterns are rarely modeled explicitly in a...

A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue

Perivascular adipose tissue (PVAT), an intriguing layer of fat surrounding blood vessels, regulates vascular tone and mediates vascular dysfunction th...

ESUS-AI:a machine learning framework to estimate the most likely embolic source in embolic stroke of undetermined source

Background and Purpose Embolic stroke of undetermined source (ESUS) emains a major diagnostic challenge in vascular neurology, as a substantial propor...

Personalised approach to hypertension treatment: Rationale and design of the HYPERMARKER randomised trial

Background and Objective: Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent o...

Benchmarking and Enhancing PPG-Based Cuffless Blood Pressure Estimation Methods

Cuffless blood pressure screening based on easily acquired photoplethysmography (PPG) signals offers a practical pathway toward scalable cardiovascula...

Feb 4 2026 2602.04725v1
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