Hematology

Latest AI and machine learning research in hematology for healthcare professionals.

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CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy

Chimeric antigen receptor (CAR) T cell therapy holds transformative potential for hematologic malign...

Leaping over the blood-brain barrier: DNA methylation as a link between peripheral and central immune systems

The majority of existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to re...

Single Capture Quantitative Oblique Back-Illumination Microscopy

Quantitative oblique back-illumination microscopy (qOBM) has emerged as a powerful technique for lab...

A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

Functional hyperaemia is a well-established hallmark of healthy brain function, whereby local brain ...

Accurate and robust classification of Mycobacterium bovis-infected cattle using peripheral blood RNA-seq data

The zoonotic bacterium, Mycobacterium bovis, causes bovine tuberculosis (bTB) and is closely related...

ppIRIS: deep learning for proteome-wide prediction of bacterial protein-protein interactions

Protein–protein interactions (PPIs) are central to cellular processes and host–pathogen dynamics, ye...

Advanced Deep Learning Enables Prediction of Allogeneic Stem Cell Mobilization Success

Hematopoietic stem and progenitor cell (HSPC) transplantation offers a potentially curative therapy ...

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in ...

Deep Learning Detection and Classification of Red Blood Cells: Towards a Universal Dataset

We evaluate emerging machine learning models for pattern recognition, focusing on the YOLOv11 archit...

CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

Brain metastasis (BrM) is a serious complication of advanced cancers and remains difficult to predic...

New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study

Sarcoidosis is a heterogeneous disease with unknown mechanisms, nonspecific therapies, and multiple ...

Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells

In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridizat...

System-level health profiling from blood DNA methylation with explainable deep learning

Genome-scale DNA methylation (DNAm) profiles capture organismal physiology, but most predictive mode...

A structure and function-based complete mutational map of Human Hemoglobin using AI

Hemoglobin (Hb), a well-characterized protein central to oxygen transport and molecular medicine, se...

Automatic Classification of Circulating Blood Cell Clusters based on Multi-channel Flow Cytometry Imaging

Circulating blood cell clusters (CCCs) containing red blood cells (RBCs), white blood cells (WBCs), ...

CellDiffusion: a generative model to annotate single-cell and spatial RNA-seq using bulk references

Annotating single-cell and spatial RNA-seq data can be greatly enhanced by leveraging bulk RNA-seq, ...

Facial photographs as proxies for inflammatory aging

Systemic chronic inflammation is a major determinant of aging and disease risk, yet current biomarke...

XChrom: a cross-cell chromatin accessibility prediction model integrating genomic sequence and cellular context

Single-cell chromatin accessibility offers unique insights into transcriptional regulation beyond ge...

Predicting Toxicity and Bioactivity of the Chemical Exposome: A Case Study for the Blood Exposome Database

Humans are exposed to thousands of chemicals throughout their life. Many of these chemicals are dete...

Deep Learning links TP53 genotype to expression-defined transcriptional program in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a hematological cancer characterized by genetic diversity and poor c...

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