Latest AI and machine learning research in hematology for healthcare professionals.
Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasis underlie distinct clinical phenotypes and the positive and negative molecular regulators of disease severity across tissue compartments. We performed comprehensive RNA-sequencing of skin an...
Cancer subtype classification is critical for precision therapy and there is a growing trend of augmenting histopathology testing procedures with omics-based machine learning classifiers. However, analytical challenges remain for pediatric cancer on the scope and precision of the current classifiers as well as the evolving subtype standardization. To address these challenges, we built Cancer Ident...
Crossing the blood–brain barrier (BBB) remains a major obstacle for central nervous system therapeutics. Short peptides have emerged as promising vect...
Chimeric antigen receptor (CAR) T cell therapy holds transformative potential for hematologic malignancies, yet predicting patient-specific treatment ...
The majority of existing DNA methylation (DNAm) studies have used peripheral surrogate tissues to research molecular mechanisms underlying brain-relat...
Quantitative oblique back-illumination microscopy (qOBM) has emerged as a powerful technique for label-free, 3D quantitative phase imaging of arbitrar...
The rapid advancement in single-cell, spatial omics, imaging, and genomic technologies requires robust analytical and visualisation platforms capable ...
Functional hyperaemia is a well-established hallmark of healthy brain function, whereby local brain blood flow adjusts in response to a change in the ...
Extracellular vesicles (EVs), including exosomes, are emerging as promising carriers of disease-specific biomarkers due to their molecular cargo refle...
The zoonotic bacterium, Mycobacterium bovis, causes bovine tuberculosis (bTB) and is closely related to Mycobacterium tuberculosis, the primary cause ...
Protein–protein interactions (PPIs) are central to cellular processes and host–pathogen dynamics, yet bacterial interactomes remain poorly mapped, esp...
Hematopoietic stem and progenitor cell (HSPC) transplantation offers a potentially curative therapy for aggressive hematologic malignancies and bone m...
All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors1,2. Physiology...
Epigenetic clocks can predict biological age but cannot prescribe the interventions needed to reverse it. Here, we introduce REjuVenatIon Via Epigenet...
We evaluate emerging machine learning models for pattern recognition, focusing on the YOLOv11 architecture for detecting and classifying red blood cel...
Red blood cell (RBC) alloimmunization is a common complication from blood transfusion, often resulting in accelerated donor RBC destruction. Patients ...
Brain metastasis (BrM) is a serious complication of advanced cancers and remains difficult to predict before clinical symptoms appear. To investigate ...
Sarcoidosis is a heterogeneous disease with unknown mechanisms, nonspecific therapies, and multiple etiologies. The role of blood extracellular vesicl...
In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridization are routinely employed to detect malignancy-as...
Genome-scale DNA methylation (DNAm) profiles capture organismal physiology, but most predictive models lack transparency and multi-level applicability...