Hematology

Prognostic Modeling Based on Post-Endovascular Thrombectomy Systolic Blood Pressure Trajectories Using Explainable Artificial Intelligence: A Secondary Analysis of the OPTIMAL-BP Trial.

Blood pressure (BP) management following successful reperfusion after endovascular thrombectomy (EVT) is critical in achieving favorable clinical outcomes. Individualized BP management using predictive modeling by machine learning may further improve prediction of functional outcomes. This study was a retrospective analysis of data from the Outcome in Patients Treated with Intra-Arterial Thrombect...

Integrative multi-omics analysis identifies coronin 1C as a potential mediator linking circadian rhythm disruption to neuroimmune dysregulation in ischemic stroke.

INTRODUCTION: Circadian rhythm disruption (CRD) is a major driver of immune dysregulation; however, whether CRD promotes ischemic stroke (IS) progression through immune imbalance and the underlying molecular mechanisms remain unclear. METHODS: Transcriptomic data from human IS brain tissues were analyzed to identify CRD associated regulators using machine-learning approaches. A CRD score model was...

The association of systemic inflammatory indices with all-cause mortality risks in patients with COPD: A cohort study based on machine learning.

This study aimed to comprehensively assess the prognostic value of routinely obtained blood-based systemic inflammatory indices in predicting all-caus...

Noninvasive Screening for High-Risk Esophageal Varices in Cirrhosis: Current and Emerging Methods.

The primary goal of variceal screening in patients with cirrhosis is to identify high-risk esophageal varices (HREV) and implement preventative measur...

AI assessment of surgical technical skill adaptation across depth levels in simulated tumor resection: a case series study.

OBJECTIVE: Surgical procedures involving varying tissue depths present challenges to surgeons regarding accessibility and precision, restricting instr...

The Prognostic and Biological Value of PGF-Based H&E Pathomics in Hepatocellular Carcinoma.

PURPOSE: Placental growth factor (PGF) is associated with the progression of hepatocellular carcinoma (HCC), but current research on this relationship...

Advancing IBD Management: A Literature Review on the Role of Non-Invasive Blood-Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment.

Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflamm...

A NETs-centric multi-omics framework prioritizes PGLYRP1 and MMP9 as subtype-associated thromboinflammatory biomarker candidates and putative therapeutic hypotheses in ischemic stroke.

Neutrophil extracellular traps are implicated in immunothrombosis and neuroinflammation in ischemic stroke, but blood-based markers that distinguish s...

Risk prediction for linezolid-induced thrombocytopenia and exposure-guided safety optimization.

Linezolid (LZD)-associated thrombocytopenia (TP), a type of major hematotoxicity that can lead to the discontinuation of LZD treatment in patients wit...

Performance of large language models and clinical decision support in perioperative management of oral anticoagulants.

BACKGROUND: Perioperative anticoagulant management is critical because of the competing risks of ischemia and bleeding. Large language models (LLMs) a...

Data-Driven Modeling of Composition-Processing-Microstructure Relations for Recycled Aluminum Cast Alloys.

Aluminum is the second most widely used metal worldwide, with essential roles in transportation, construction, packaging, and energy infrastructure. R...

Peripheral blood mononuclear cell DNA methylation signatures guide surgical decision-making in indeterminate pulmonary nodules.

BACKGROUND: Distinguishing malignant from benign pulmonary nodules remained a significant clinical challenge. Given the involvement of DNA methylation...

Identification and Screening of Lactate-Related Genes as Molecular Markers for Early Diagnosis of Steroid-Induced Osteonecrosis of the Femoral Head.

Steroid-induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle-aged adults. However, current diagnosi...

[Artificial intelligence-assisted diagnostics in the pathology of internal and oncological diseases].

BACKGROUND: Artificial intelligence (AI) is increasingly being implemented in digital pathology to support the tissue classification, cell detection, ...

Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression.

INTRODUCTION: Sarcoidosis is a heterogeneous granulomatous disease with highly variable clinical trajectories, yet no validated biomarkers exist to di...

Label-free and non-invasive recovery of circulating tumor cells using an integrated acoustofluidic-SERS chip.

Accurate capture and molecular analysis of circulating tumor cells (CTCs) from whole blood are crucial for early cancer diagnosis, prognosis and perso...

Hybrid ML-driven simulation exploring the fate of environmentally relevant nanoplastics in complex aqueous matrices: Mechanistic insight into colloidal behavior via explainable AI.

Nanoplastics (NPs) are globally recognized as pervasive emerging contaminants with demonstrated toxicological risks, yet predicting their environmenta...

AI-driven Predictive Models in Endourological Treatment of Urolithiasis: A Systematic Review of Nomogram Applications from EAU Endourology.

BACKGROUND: Artificial intelligence (AI) is increasingly applied in endourology to enhance surgical planning, risk stratification, and outcome predict...

Evaluation of an AI-Driven Risk Stratification System for Clinical Deterioration in Geriatric Hip Fracture Patients.

OBJECTIVES: To determine whether an artificial-intelligence-driven Clinical Deterioration Index (CDI) could identify geriatric hip-fracture patients a...

A machine learning predictive model for staging chronic hepatitis B inflammation based on non-invasive metrics.

Early screening and antiviral therapy for significant liver inflammation in chronic hepatitis B (CHB) remain significant barriers as the key to diseas...