Hemophilia

Tspan4+ fibroblasts facilitate the development of NECSO in myocardial ischemia reperfusion through migrasomes-mediated Tnf-α autocrine and cardiomyocytes aldosterone generation.

Myocardial ischemia/reperfusion (I/R) is the preferred treatment for acute myocardial infarction, yet it still results in cardiomyocytes (CMs) injury. Sodium ion is essential for maintaining ionic balance and bioelectrical activity in CMs. However, whether sodium ion overload leads to CMs Necrosis by Sodium Overload (NECSO) remains uncertain. In this study, CoroNa Green revealed that I/R induces s...

Bioinformatics and machine learning identify ITIH4 and ZC3H13 as novel mRNA biomarkers for major depressive disorder that promote microglial M1 polarization.

UNLABELLED: Major depressive disorder (MDD), a prevalent mental illness, currently lacks reliable biomarkers and depends predominantly on subjective diagnostic criteria. Neuroinflammation, particularly microglial M1 polarization, plays a pivotal role in MDD pathogenesis. Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) and zinc finger CCCH-type containing 13 (ZC3H13) are inflammation-related genes,...

Repurposing Azilsartan medoxomil attenuates periodontitis by targeting SERPINB9 to promote apoptosis of IL1B+ macrophages.

Periodontitis (PD) is a common chronic inflammatory disease characterized by progressive destruction of periodontal tissues and is associated with sys...

Contrasting roles of PD-L1 expression in tumor and stroma: Biological and prognostic implications in esophageal squamous cell carcinoma.

Programmed death-ligand 1 (PD-L1) plays a central role in immune regulation in esophageal squamous cell carcinoma (ESCC) and has been widely used as a...

Integrated machine learning and multi-omics analysis identifies ALOX5 as a potential therapeutic target for tubulointerstitial inflammation in diabetic kidney disease.

Diabetic kidney disease (DKD) is a leading cause of renal failure. Inflammation of the renal tubules and interstitium is a critical factor in the prog...

Percutaneous coronary intervention in high bleeding risk patients: a review of contemporary management strategies.

INTRODUCTION: High bleeding risk (HBR) affects over one-third of patients undergoing percutaneous coronary intervention (PCI) and is associated with e...

Exploration of network-based, machine learning, MD simulations, and MM/GBSA approaches revealed luteolin from Gynura procumbens as key inhibitor of MMP9 in NSCLC.

The primary leading reason for cancer death is non-small-cell lung cancer (NSCLC) still up to date globally. Even with today's advanced technology, it...

Antibody-drug conjugate design and mechanisms of action for cancer treatment: state of the art and beyond.

Antibody-drug conjugates (ADCs) are a leading area of targeted cancer therapeutics, typically combining a tumour-associated antigen-specific antibody ...

Structural and dynamic characterization of papain-like protease ligand recognition using integrated computational and biochemical approaches.

The papain-like protease (PLpro) is a structurally conserved cysteine protease whose catalytic activity and regulatory functions are governed by a wel...

Zero-shot prediction of drug responses using biologically informed neural networks trained on phosphoproteomic timeseries.

Cellular signaling is driven by complex, dynamic phosphorylation networks that control growth and survival, and their dysregulation underlies diseases...

Comprehensive Multiomics Characterization of Perineural Invasion in Cervical Cancer Reveals Diagnostic Markers, Molecular Drivers, and Therapeutic Strategies.

UNLABELLED: Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key in...

Recent developments in pharmacophore-based modeling of Ca2+/Calmodulin-dependent protein kinase II delta (CaMkIIδ) inhibitors for heart failure therapy.

INTRODUCTION: Calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) regulates cardiac excitation - contraction coupling and contributes to he...

RaMoA: Raman Microspectroscopy and Deep Learning for the Classification of Antimicrobial Mechanism of Action.

We propose an innovative technology based on the combination of Raman microspectroscopy and deep learning to classify the Mechanism of Action (MoA) of...

Immune-activated & pathology-characterized: the distinct clear cell renal cell carcinoma subtypes for 3PM strategies derived from artificial intelligence in multi-omics.

BACKGROUND AND OBJECTIVE: Renal clear cell carcinoma (ccRCC) is highly heterogeneous, with significant differences in clinical outcomes such as progno...

Olfactomedin 1 acts as a tumor suppressor in glioblastoma: integrated analysis and mechanistic prediction.

Glioblastoma (GBM) is an aggressive brain tumor with a poor prognosis, yet its molecular mechanisms remain incompletely understood. Olfactomedin 1 (OL...

Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly.

The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of ...

De novo design of Ras isoform selective binders.

The four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents ...

BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.

BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acquired resistance remains a major barrier to curati...

A metabolic-immune subtype of breast cancer defined by G6PD and SHMT2: From single‑cell dissection to dual-targeted therapy.

Breast cancer heterogeneity limits the precision of current prognostic and therapeutic strategies, underscoring the need for molecular frameworks that...

AI-driven identification of a selective dual function inhibitor blocking HK2 activity and HK2-VDAC1 interaction displaying enhanced anticancer efficacy under hypoxia.

Selective inhibition of hexokinase 2 (HK2) represents a promising therapeutic strategy due to the pivotal role of HK2 in the Warburg effect, enhanceme...