Hemophilia

Dual-Mode Detection of Trypsin and Screening of Trypsin Inhibitors on the Basis of a Colorimetric/Fluorescence Sensing Probe.

Trypsin is a specific and reliable diagnostic biomarker of pancreatic function and pathological changes. Thus, detecting trypsin and screening trypsin inhibitors are highly important for clinical diagnosis and disease treatment. Herein, we propose a colorimetric/fluorescence sensing probe based on carbon quantum dots (O-CDs) and cytochrome C (Cyt C) for sensitive and specific trypsin detection and...

Multiple mutations in succinate dehydrogenase subunits conferring resistance to fungicide Pydiflumetofen in Magnaporthe oryzae.

BACKGROUND: Magnaporthe oryzae is the causal agent of rice blast disease. Pydiflumetofen, a novel succinate dehydrogenase inhibitor (SDHI), has promising potential for controlling rice blast owing to the antifungal activity of this fungicide.

Serum sclerostin as a marker of microvascular and macrovascular complications among children and adolescents with type 1 diabetes mellitus.

BACKGROUND: Uncontrolled diabetes mellitus (DM) accelerates atherosclerosis and vascular diseases, leading to micro- and macrovascular complications. ...

Dynamics of Modified Cardiovascular Risk Factors in Patients with Rheumatoid Arthritis on the Background of 5-Year Therapy with an Interleukin 6 Receptor Inhibitor.

UNLABELLED: The effect of an inhibitor of interleukin (IL) 6 receptors on the state of the cardiovascular system in patients with rheumatoid arthritis...

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib.

Fruquintinib (FRUZAQLA) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (-1, -2, and -3). Tw...

Efficacy and Safety of rVIII-SingleChain in Surgical Prophylaxis.

INTRODUCTION: RVIII-SingleChain is a B-domain-truncated factor VIII construct with a covalent bond between the factor VIII heavy and light chains.

Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.

OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of...

HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia.

BACKGROUND: Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) ...

Study on the effect and mechanism of PM on the expression of alzheimer's-like lesions related proteins in SH-SY5Y cells.

Fine particulate matter (PM) is recognized as one of the most harmful environmental pollutants to human health. Current research indicates that PM exh...

Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.

Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East Asia, has been recognized for its anticancer proper...

Inhibition mechanism of α-amylase and amyloglucosidase by spherical nanocrystalline cellulose with varying particle sizes.

In this study, spherical nanocrystalline cellulose (SNC) was isolated from native cellulose through phosphoric acid hydrolysis and ultrasonic treatmen...

Mechanisms involved in pro-inflammatory responses to traffic-derived particulate matter (PM) in THP-1 macrophages compared to HBEC3-KT bronchial epithelial cells.

The pro-inflammatory responses in THP-1-derived macrophages and human bronchial epithelial cells (HBEC3-KT) were examined after exposure to size-fract...

Discovery of Diphenylsilane Compounds as Potential Inhibitors of Zn-Metalloproteinase Thermolysin Using Artificial Neural Networks.

INTRODUCTION/OBJECTIVE: Artificial neural networks are very powerful machine learning and artificial intelligence tools for computer-aided drug discov...

Biocatalytic production of a monoamine oxidase B/catechol-O-methyltransferase inhibitor from piperine by engineered P450 BM3.

The single-step biotransformation of the natural compound piperine into a known dual inhibitor of monoamine oxidase B (MAO-B) and catechol-O-methyltra...

Comprehensive analysis of Syzygium cumini L. pomace extract as an α-amylase inhibitor: In vitro inhibition, kinetics, and computational studies.

Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by impaired regulation of blood glucose levels. Jamun (Syzygium cumin...

A cascade nanoreactor based on metal azolate framework integrated natural enzyme for α-glucosidase activity assay and inhibitor screening.

Enzyme cascades have attracted widespread attention owing to the exceptional specificity and efficient signals transduction, however, constrained by t...

A new computational cross-structure-activity relationship (C-SAR) approach applies to a selective HDAC6 inhibitor dataset for accelerated structure development.

Several structure-activity relationship (SAR) methodologies have been developed for the research community to improve the potential activity of protot...

Ligand-Based Drug Discovery Leveraging State-of-the-Art Machine Learning Methodologies Exemplified by Cdr1 Inhibitor Prediction.

Artificial intelligence (AI) is revolutionizing drug discovery with unprecedented speed and efficiency. In computer-aided drug design, structure-based...

Exploring 4 generation EGFR inhibitors: A review of clinical outcomes and structural binding insights.

Epidermal growth factor receptor (EGFR) is a potential target for anticancer therapies and plays a crucial role in cell growth, survival, and metastas...

DruGagent: Multi-Agent Large Language Model-Based Reasoning for Drug-Target Interaction Prediction.

Advancements in large language models (LLMs) allow them to address diverse questions using human-like interfaces. Still, limitations in their training...