Hemophilia

Mesoscopic structural analysis via deep learning processing, with a special reference to in vitro alteration in collagen fibre induced by a gap junction inhibitor.

Dense connective tissue, including the ligament, tendon, fascia and cornea, is formed by regularly a...

SPLDExtraTrees: robust machine learning approach for predicting kinase inhibitor resistance.

Drug resistance is a major threat to the global health and a significant concern throughout the clin...

Low Risk of Venous Thromboembolism After Robot-assisted Radical Prostatectomy Through Systemic Image Assessment: A Prospective Study.

BACKGROUND/AIM: The aim of the study was to evaluate the risk of venous thromboembolism (VTE) after ...

[Bridge between Total Synthesis of Bioactive Natural Products and Development of Drug Leads].

Although natural products are rich sources for drug discovery, only a small percentage of natural pr...

Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.

Dermatomyositis is a common connective tissue disease. The occurrence and development of dermatomyos...

Anticoagulant treatment in elderly patients with atrial fibrillation: a position paper.

Atrial fibrillation (AF) is common in the elderly. The treatment of this condition is based on antic...

Successful Resuscitation of a Young Girl Who Drank Rivastigmine With Respiratory Failure.

Rivastigmine is a non-competitive reversible inhibitor of acetylcholinesterase which is approved as ...

Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer.

Evaluation of Cyclosporine Pharmacokinetic, Monitoring, and Dosing Parameters for GVHD Prophylaxis in Hematopoietic Stem Cell Transplant (HSCT) Recipients.

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a major method of treatment for differ...

Programmed cell death protein-1/programmed death-ligand 1 blockade enhances the antitumor efficacy of adoptive cell therapy against non-small cell lung cancer.

BACKGROUND: Cytokine-induced killer (CIK) cells and natural killer (NK) cells are employed by two di...

Clinical observation of the efficacy of low-molecular-weight heparin calcium in prophylaxis of the deep venous thrombosis following the gynecological tumor surgery.

Present study is conducted to investigate the efficacy and safety of application of low-molecular-we...

The Association Between Arthralgia and Vedolizumab Using Natural Language Processing.

BACKGROUND: The gut-selective nature of vedolizumab has raised questions regarding increased joint p...

[Optimization and evaluation of an inflammatory cell model in LPS-stimulated PMA-differentiated THP-1 cells].

Objective To develop an optimal inflammatory cell model from lipopolysaccharide (LPS)-stimulated pho...

[Y-27632 protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy pathway].

Objective To investigate the protective effect of preconditioning with Rho-kinase inhibitor Y-27632 ...

Pattern and predictors of urine protein excretion among patients with type 2 diabetes attending a single tertiary hospital in Lagos, Nigeria.

Testing for proteinuria is used to screen for diabetic nephropathy. However, significant proportion ...

Antiphospholipid Syndrome with Antiβ2glicoprotein-1 Antibodies as the Cause of Recurrent Tibial Vein Thrombosis in SAPHO syndrome.

The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in ...

Plasma cytokine profiling to predict susceptibility to acute mountain sickness.

Extensive studies have been performed on acute mountain sickness (AMS), but biomarkers predicting AM...

G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis.

Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases and a major cause of li...

Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

High content analysis (HCA) has become a leading methodology in phenotypic drug discovery efforts. T...

Self-Organizing Map (SOM) and Support Vector Machine (SVM) Models for the Prediction of Human Epidermal Growth Factor Receptor (EGFR/ ErbB-1) Inhibitors.

EGFR (ErbB-1/HER1) kinase plays an important role in cancer therapy. Two classification models were ...

Discrimination of Active and Weakly Active Human BACE1 Inhibitors Using Self-Organizing Map and Support Vector Machine.

β-secretase (BACE1) is an aspartyl protease, which is considered as a novel vital target in Alzheime...