Hematology

Hemophilia

Latest AI and machine learning research in hemophilia for healthcare professionals.

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Showing 568-588 of 4,984 articles
Non-weight-based enoxaparin dosing subtherapeutic in trauma patients.

BACKGROUND: We report our experience dosing and monitoring enoxaparin with anti-factor Xa activity (...

(1)
Oct 2015 26850200
Gingipains from Porphyromonas gingivalis promote the transformation and proliferation of vascular smooth muscle cell phenotypes.

The aim of the present study was to ascertain the effect of Porphyromonas gingivalis cysteine protea...

Oct 2015 26770435
Effect of MRP2 and MRP3 Polymorphisms on Anastrozole Glucuronidation and MRP2 and MRP3 Gene Expression in Normal Liver Samples.

Anastrozole is an aromatase inhibitor (AI) used as adjuvant therapy for breast cancer. Anastrozole i...

Sep 2015 26985457
CYP19A1 Genetic Polymorphisms rs4646 and Osteoporosis in Patients Treated with Aromatase Inhibitor-Based Adjuvant Therapy.

OBJECTIVE: Third-generation aromatase inhibitors (AI) are potent suppressors of aromatase activity. ...

(1)
Jul 2015 27026757
A Stability-Indicating HPLC Method for the Determination of Fingolimod in Pharmaceutical Dosage Forms.

Fingolimod is an immunosuppressive agent which is used for the prophylaxis of organ transplantation ...

Sep 2014 26839803
A deep learning-generated hASIC1a miniprotein inhibitor confers neuroprotection in stroke

Ion channels remain notoriously recalcitrant drug targets despite their extensive pathophysiological...

(14)
Patterns of GLP-1 Receptor Agonist Initiation Compared With Other Glucose-Lowering and Anti-Obesity Therapies Among Older Adults

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have rapidly expanded from primaril...

A Dynamics-Informed Machine Learning Framework for Inhibitor Optimization Against Quickly Evolving Targets to Avoid Resistance

Drug resistance often emerges through mutations that reshape protein conformational ensembles, allow...

SpatialTRACE predicts anatomical axes and regions in spatial transcriptomics and microscopy

Spatial transcriptomics measures gene expression in tissue sections. However, interpretation require...

Population-Scale Precision Safety in Oncology Reveals Clinical and Genetic Determinants of Systemic Therapy Toxicity

Treatment toxicity constrains the use of effective cancer therapies, but its clinical and genetic de...

Evaluating GPT-4o Model Proficiency and Clinical Reasoning for Antimicrobial Stewardship in Dentistry

Objectives: Dentists prescribe approximately one in ten antibiotics worldwide, yet antimicrobial ste...

PINPOINT: Protease INhibitor PredictiOn at the plant-pathogen INTerface using protein language models and structural modeling

Cysteine and serine proteases act as an immune hub in the plant apoplast to provide robust extracell...

External Validation and Calibration Assessment of Explainable Machine Learning Models for GVHD Prediction After Allogeneic HSCT

BackgroundGraft-versus-host disease (GVHD) remains a major determinant of morbidity and mortality fo...

Machine learning-based modeling to predict inhibitors for targets of Alzheimer's Disease

Alzheimer's Disease is a chronic neurodegenerative disorder projected to affect 115 million people b...

Neuroanatomical dimensions in recent-onset depression: clinical profiles, inflammatory markers, and proteomic ageing

Background: Major depressive disorder (MDD) is clinically heterogeneous, hindering identification of...

Comfort with AI for HIV Prevention Among Cisgender Women in New York City

Background: Long-acting pre-exposure prophylaxis (PrEP) expands HIV prevention options for women. Ho...

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