Latest AI and machine learning research in hemophilia for healthcare professionals.
Background.Renoprotective therapies - SGLT2 inhibitors, finerenone, and renin-angiotensin system inh...
Liver sinusoidal endothelial cells (LSECs) are increasingly recognized as a critical yet underexplor...
Treatment of advanced head and neck squamous cell carcinoma (HNSCC) often involves radiotherapy comb...
Cancer cells display heterogeneous pathway activity that shapes therapeutic vulnerability, but mappi...
A key question in cell biology is how cell-scale organization emerges from a given set of molecular ...
The ABACUS study was a single arm, phase II trial evaluating neoadjuvant atezolizumab in operable ur...
Second generation antiandrogens, such as enzalutamide, are commonly prescribed to treat advanced pro...
Metabolic dysfunction is increasingly recognized as a risk factor for poor outcomes in breast cancer...
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but can cause ser...
Rational design of covalent inhibitors requires simultaneously optimizing multiple properties, such ...
Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic dysregulation of the disease l...
Drug discovery is often constrained by target identification, a bottleneck especially acute in antim...
Immunotherapy with immune checkpoint inhibitors and immunotherapy combined with chemotherapy have re...
Heart failure with preserved ejection fraction (HFpEF) affects over 30 million people and lacks dise...
Kinase family proteins constitute the second largest protein class targeted in drug development effo...
Biomedical knowledge graphs encode millions of relationships between drugs, proteins, pathways, and ...
Most CYP51 inhibitors act competitively and are prone to resistance, whereas allosteric inhibitors h...
Bioactivity optimization is a crucial and technical task in the early stages of drug discovery, trad...
Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with...
With the incorporation of effective therapies for myelofibrosis (MF), accurately predicting outcomes...
Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for locally advanced rectal cancer (...