Hematology

Hemophilia

Latest AI and machine learning research in hemophilia for healthcare professionals.

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Showing 610-630 of 4,984 articles
Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.

The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its signifi...

(1)
Jun 2025 40288261
Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

The leucine-rich repeat kinase 2 (LRRK2) is the most mutated gene in familial Parkinson's disease, a...

Jun 2025 40415386
Identification of therapeutics against PfPK6 protein of Plasmodium falciparum: Structure and Deep Learning approach.

The Plasmodium falciparum Protein Kinase 6 (PfPK6) is a serine/threonine protein kinase categorized ...

Jun 2025 40288672
Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure.

Antibody-drug conjugates (ADCs) are promising cancer therapeutics, but optimizing their cytotoxic pa...

(1)
May 2025 40430004
Protein Profiles Predict Treatment Responses to the PI3K Inhibitor Umbralisib in Patients with Chronic Lymphocytic Leukemia.

PURPOSE: The management of chronic lymphocytic leukemia (CLL) has significantly improved with target...

May 2025 40085050
Transforming Healthcare: The Role of Artificial Intelligence.

The integration of artificial intelligence (AI) into healthcare is revolutionising the industry by e...

(2)
May 2025 40380728
Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses.

Mitochondrial heterogeneity drives diverse cellular responses in neurodegenerative diseases, complic...

May 2025 40369116
A deep learning and molecular modeling approach to repurposing Cangrelor as a potential inhibitor of Nipah virus.

Deforestation, urbanization, and climate change have significantly increased the risk of zoonotic di...

May 2025 40355437
Identification of predictive subphenotypes for clinical outcomes using real world data and machine learning.

Predicting treatment response is an important problem in real-world applications, where the heteroge...

(1)
May 2025 40355420
Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: Artificial intelligence analysis.

Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor r...

May 2025 40088978
Clinical characteristics, outcomes, and predictive modeling of patients diagnosed with immune checkpoint inhibitor therapy-related pneumonitis.

PURPOSE: The aim of this study is to better characterize the clinical characteristics and outcomes o...

(1)
May 2025 40343491
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation.

Hematopoietic progenitor kinase 1 (HPK1) is a key negative regulator of T-cell receptor (TCR) signal...

(1)
May 2025 38198294
Molecular Determinants of Orthosteric-allosteric Dual Inhibition of PfHT1 by Computational Assessment

To overcome antimalarial drug resistance, carbohydrate derivatives as selective PfHT1 inhibitor ha...

Predicting Targeted Therapy Resistance in Non-Small Cell Lung Cancer Using Multimodal Machine Learning

Lung cancer is the primary cause of cancer death globally, with non-small cell lung cancer (NSCLC)...

(2)
ProtoBERT-LoRA: Parameter-Efficient Prototypical Finetuning for Immunotherapy Study Identification

Identifying immune checkpoint inhibitor (ICI) studies in genomic repositories like Gene Expression...

(2)
Machine Learning-Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent.

The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglu...

Mar 2025 40077992
COX-2 Inhibitor Prediction With KNIME: A Codeless Automated Machine Learning-Based Virtual Screening Workflow.

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in inflammation by converting arachi...

Jan 2025 39797538
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phen...

Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model

The process of α-synuclein aggregation results in the formation of amyloid fibrils, which accumulate...

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