Hemophilia

E(3)-invariant diffusion model for pocket-aware peptide generation

Biologists frequently desire protein inhibitors for a variety of reasons, including use as researc...

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors.

The identification of an effective inhibitor is an important starting step in drug development. Unfo...

Histopathology Based AI Model Predicts Anti-Angiogenic Therapy Response in Renal Cancer Clinical Trial

Predictive biomarkers of treatment response are lacking for metastatic clear cell renal cell carci...

Predicting gastric cancer tumor mutational burden from histopathological images using multimodal deep learning.

Tumor mutational burden (TMB) is a significant predictive biomarker for selecting patients that may ...

Clinical Validation of Artificial Intelligence-Powered PD-L1 Tumor Proportion Score Interpretation for Immune Checkpoint Inhibitor Response Prediction in Non-Small Cell Lung Cancer.

PURPOSE: Evaluation of PD-L1 tumor proportion score (TPS) by pathologists has been very impactful bu...

Predicting Immune Checkpoint Inhibitor-Related Pneumonitis via Computed Tomography and Whole-Lung Analysis Deep Learning.

BACKGROUND: Immune checkpoint inhibitor-related pneumonitis (ICI-P) is a fatal adverse event of immu...

Elevated tissue factor pathway inhibitor is associated with intracerebral haemorrhage of unknown cause in young adults.

CLINICAL RATIONALE FOR STUDY: We have reported that intracerebral haemorrhage (ICH) of unknown cause...

Inhibition of choline kinase as an antiamoebic approach in Entamoeba histolytica infection.

Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic coliti...

Extended Venous Thromboembolism Prophylaxis after Robotic Staging for Endometrial Cancer.

OBJECTIVES: Our objectives were to estimate the incidence of venous thromboembolism (VTE) after robo...

Mesoscopic structural analysis via deep learning processing, with a special reference to in vitro alteration in collagen fibre induced by a gap junction inhibitor.

Dense connective tissue, including the ligament, tendon, fascia and cornea, is formed by regularly a...

SPLDExtraTrees: robust machine learning approach for predicting kinase inhibitor resistance.

Drug resistance is a major threat to the global health and a significant concern throughout the clin...

Low Risk of Venous Thromboembolism After Robot-assisted Radical Prostatectomy Through Systemic Image Assessment: A Prospective Study.

BACKGROUND/AIM: The aim of the study was to evaluate the risk of venous thromboembolism (VTE) after ...

[Bridge between Total Synthesis of Bioactive Natural Products and Development of Drug Leads].

Although natural products are rich sources for drug discovery, only a small percentage of natural pr...

Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.

Dermatomyositis is a common connective tissue disease. The occurrence and development of dermatomyos...

Anticoagulant treatment in elderly patients with atrial fibrillation: a position paper.

Atrial fibrillation (AF) is common in the elderly. The treatment of this condition is based on antic...

Successful Resuscitation of a Young Girl Who Drank Rivastigmine With Respiratory Failure.

Rivastigmine is a non-competitive reversible inhibitor of acetylcholinesterase which is approved as ...

Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer.

Evaluation of Cyclosporine Pharmacokinetic, Monitoring, and Dosing Parameters for GVHD Prophylaxis in Hematopoietic Stem Cell Transplant (HSCT) Recipients.

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a major method of treatment for differ...

Programmed cell death protein-1/programmed death-ligand 1 blockade enhances the antitumor efficacy of adoptive cell therapy against non-small cell lung cancer.

BACKGROUND: Cytokine-induced killer (CIK) cells and natural killer (NK) cells are employed by two di...

Clinical observation of the efficacy of low-molecular-weight heparin calcium in prophylaxis of the deep venous thrombosis following the gynecological tumor surgery.

Present study is conducted to investigate the efficacy and safety of application of low-molecular-we...

The Association Between Arthralgia and Vedolizumab Using Natural Language Processing.

BACKGROUND: The gut-selective nature of vedolizumab has raised questions regarding increased joint p...