HRT

Body composition's effect on the bone-vascular axis of osteoporosis discovered in AI-based CT analysis of COPD patients.

OBJECTIVES: This study aimed to investigate the effect of body composition on the inverse relationship between vertebral bone density (T12 BMD) and total thoracic vascular calcification (TTVC) in patients with chronic obstructive pulmonary disease (COPD). Moreover, we aimed to assess whether intermuscular adipose tissue (IMAT) affects the bone-vascular axis. MATERIALS AND METHODS: Chest CT scans o...

Digital twins in menopause: a roadmap for integrating endocrine dynamics, multisystem physiology, and precision medicine.

The menopausal transition represents one of the most complex and heterogeneous periods of women's midlife health, marked by non-linear hormonal fluctuations and interconnected changes across cardiovascular, skeletal, metabolic, neurocognitive, and thermoregulatory systems. Despite decades of research, current approaches remain limited by sparse longitudinal measurements, fragmented organ-specific ...

An explainable machine learning model for predicting one-year osteoporosis risk: development and validation in a prospective cohort.

OBJECTIVE: This study aimed to develop and validate an interpretable machine learning model using readily available biochemical indicators to predict ...

Unraveling the adverse outcome pathways of metabolic dysfunction-associated steatotic liver disease triggered by environmental mixtures via biological knowledge-driven machine learning.

Environmental pollutant mixtures are potential risk factors for metabolic dysfunction-associated steatotic liver disease (MASLD), yet their joint effe...

BHOD: a bone health optimized dietary pattern designed for osteoporosis prevention.

Existing dietary patterns were not specifically designed to target osteoporosis and lack the precision required for effective prevention. We aimed to ...

Ultrasound-Based AI in Predicting Hormone Receptor Status in Breast Cancer: Is "Digital Biopsy" Possible.

Accurate and rapid determination of tumor histopathological features and molecular subtypes is critical for breast cancer prognosis and treatment stra...

Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

INTRODUCTION: Osteoporosis (OP) is a multifactorial skeletal disorder marked by reduced bone mass and microstructural deterioration. We investigated p...

Artificial Intelligence for Opportunistic Screening for Osteoporosis and Spine Fractures Using Computed Tomography: A Systematic Review and Meta-Analysis.

OBJECTIVE: Osteoporosis is a major global health burden and often remains undiagnosed until fragility fractures occur. Dual-energy x-ray absorptiometr...

The future of DXA: How AI is transforming bone health diagnostics.

Dual-energy X-ray absorptiometry (DXA) remains the clinical gold standard for assessing bone mineral density (BMD), guiding diagnosis and therapeutic ...

Deep Learning for Opportunistic Vertebral Fracture Detection on Routine Thoraco-abdominal Computed Tomography: A Systematic Review and Hierarchical Summary Receiver Operating Characteristic Meta-analysis of Patient-level Diagnostic Test Accuracy.

RATIONALE AND OBJECTIVES: Vertebral fractures (VFs) are common, clinically important, and often missed on routine chest or abdominal computed tomograp...

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).

Skeletal muscle functions as an endocrine organ, secreting myokines that mediate interorgan communication with bone. Exercise‑induced myokines regulat...

Identification of key predictors of postmenopausal osteoporosis from routine clinical indicators using explainable machine learning.

BACKGROUND: Machine learning (ML) shows promise in using clinical data to predict chronic diseases. However, its application in PMOP risk assessment u...

Efficacy and Hepatotoxicity of Psoralea corylifolia L.: A Meta-Analysis and Machine Learning Assessment in Postmenopausal Osteoporosis.

ETHNOPHARMACOLOGICAL RELEVANCE: Psoralea corylifolia L. (P. corylifolia, also known as Cullen corylifolium (L.) Medik.) is a traditional medicinal her...

An intelligent MRI-based all-in-one diagnostic strategy for axillary lymph node status in breast cancer.

An integrated diagnostic strategy of preoperative identification of sentinel lymph node (SLN) metastasis, SLN metastatic burden, and non-SLN (NSLN) me...

Development of an automated landmarking tool for the femur in dual-energy X-ray absorptiometry scans using contour-based image analysis.

Osteoporosis is a skeletal disease that significantly increases fracture risk and imposes a growing public health and economic burden. Notably, hip fr...

AI-derived bone mineral density from standard radiographs compared with DXA for fracture prediction in a 10-year real-world cohort study.

UNLABELLED: AI-derived bone mineral density from routine radiographs showed strong agreement with DXA and comparable ability to predict incident fract...

Understanding drug diffusion and permeation in transdermal patches: A kinetic perspective.

Transdermal drug delivery (TDD) offers a non-invasive method for systemic medication, bypassing first-pass metabolism and allowing controlled release....

Embryo transfer in dairy herds: a comprehensive review of factors affecting pregnancy success from donor to embryo and recipient.

Embryo transfer (ET) is a fundamental biotechnology in modern dairy production, utilized to maximize the propagation of superior genetics and circumve...

Clinical Implementation of Opportunistic Screening for Osteoporosis.

Opportunistic screening leverages existing imaging examinations performed for unrelated routine clinical indications to systematically extract quantit...

In Vitro Release Prediction of Colchicine Transdermal Patch Based on Raman Spectroscopy Imaging and Data-Driven Modeling.

This study explored the feasibility of combining Raman spectroscopic imaging with data-driven modeling for estimating colchicine release from transder...