HRT

Computer-aided diagnosis system for thoracic computed tomography of rib fractures in older emergency patients: A preliminary study.

The peculiarities of older individuals related to osteoporosis and hyperostosis may lead to a higher rate of misdiagnosis of rib fractures on computed tomography (CT) images in older than in middle-aged/young people when using radiologist-only reading. However, none of these studies on rib fracture computer-aided diagnostic (CAD) systems grouped patients by age or evaluated the value of using CAD ...

Deep-Learning Solution Providing Molecular Marker Subtyping of Breast Cancer Whole Slide Images: Protocol for a UK Clinical Service Evaluation Study.

BACKGROUND: As the histopathology workforce continues to struggle and service demand continues to increase, it has become prudent to consider viable avenues to try to alleviate diagnostic workload burden. One such avenue is computer-based technologies (CBTs). Breast cancer (BC) is the most common malignant neoplasm in the United Kingdom and requires additional testing for estrogen receptor (ER), p...

AI-driven discovery of synergistic combinations from Psoralea corylifolia fruit for treating osteoporosis.

BACKGROUND: Estrogen-deficient osteoporosis demands safe and effective therapies. Psoralea corylifolia fruit (PCF), a phytoestrogenic herbal medicine ...

Exploring the ROS-Related Therapeutic Mechanism of Bushen Huoxue Decoction in Postmenopausal Osteoporosis through Transcriptomics and Network Pharmacology.

INTRODUCTION: Postmenopausal osteoporosis (PMOP) involves bone loss and fracture risk, driven by estrogen deficiency, oxidative stress, immune dysregu...

Identification of estrogen-related biomarkers in metabolic dysfunction-associated steatotic liver disease (MASLD) through machine learning and single-cell analysis.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a preval...

AI-assisted extraction of opportunistic findings from oncologic CT reports using large language models.

Opportunistic findings at imaging (iOFs), such as osteoporosis, liver steatosis, or coronary artery calcifications, are clinically relevant abnormalit...

Challenges and opportunities of implementing open-source digital pathology in sub-Saharan Africa: Lessons learned from deploying QuPath for breast cancer biomarker assessment in Cameroon.

BACKGROUND: Digital pathology and artificial intelligence (AI) are transforming cancer diagnostics worldwide, yet their implementation in sub-Saharan ...

Identification of Chronic Stress-Related Biomarkers for Potential Diagnosis and Treatment of Osteoporosis: An Integrated Multi-omic and Clinical Data Analysis.

OBJECTIVE: The mechanisms through which chronic stress-related genes influence the diagnosis of osteoporosis (OP), where chronic stress serves as a ri...

MedADL: High-Throughput Information Extraction of Functional Status from Electronic Health Records to Advance Frailty Assessment in Older Adults.

BACKGROUND: Functional status is essential for assessing frailty and planning care in older adults but is often under-documented in the structured fie...

Heat shock protein-mediated remodeling of the bone immune microenvironment: mechanisms and precision therapeutic strategies for osteoporosis.

BACKGROUND: Osteoporosis is a systemic bone disorder marked by reduced bone mass and deteriorating bone microstructure, commonly associated with infla...

Comment on "Integrating machine learning into fracture liaison services: Toward precision risk stratification in osteoporosis care: A prospective cohort study".

Ultrasound-based multiregional radiomics nomogram for predicting recurrence in HER2-positive breast cancer.

PURPOSE: Accurate prediction of recurrence risk is crucial for personalizing therapy in human epidermal growth factor receptor 2-positive (HER2-positi...

ABCA8 drives bone loss via disrupting Th17/Treg imbalance: a novel immunometabolic target for osteoporosis.

BACKGROUND: Osteoporosis is a metabolic bone disease characterized by reduced bone mass and microarchitectural deterioration, with complex involvement...

An explainable machine learning approach to predict fragility fractures and the identification of important features.

In this study, we developed ML algorithms to predict fragility fractures, considering the occurrence of fractures at different skeletal sites, using t...

Integrating network toxicology, machine learning, and single-cell sequencing to reveal the FASN-mediated role of phenolic endocrine disruptors in water in promoting prostate cancer.

BACKGROUND: Phenolic endocrine-disrupting chemicals (EDCs) like nonylphenol (NP) and octylphenol (OP) are widespread water pollutants. Their estrogen-...

Fractal analysis in dentistry: a bibliometric analysis (1991-2024).

OBJECTIVES: This study aims to provide a comprehensive bibliometric mapping of the scientific evolution and research trends of fractal analysis (FA) i...

Environmental Levels of Sodium p-Perfluorous Nonenoxybenzene Sulfonate Induce Nephritis in Renal Proximal Tubular Epithelial Cells via Modulation of Estrogen Signaling Pathways.

Sodium p-perfluorous nonenoxybenzene sulfonate (OBS), widely used as an alternative to per- and polyfluoroalkyl substances, has been implicated in tox...

Exosomes in bone health and disease: cellular crosstalk, systemic signaling, and AI-driven advances in regenerative therapy.

Exosomes have emerged as critical mediators of intercellular and inter-organ communication in bone biology. Secreted by bone-resident cells such as os...

Machine learning identifies traffic-related pollutant mixtures as potential factors suggestive of association with osteoporosis in a cross-sectional analysis of NHANES.

The combined effect of traffic-related pollutant mixtures on osteoporosis (OP) remains unclear. This study aimed to evaluate such associations using m...

Integration of network pharmacology, deep learning, and molecular biology reveals the efficacy of Citrus aurantium L. var. amara Engl. blossom extract in ameliorating diabetic osteoporosis.

ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic osteoporosis (DOP) is a type of metabolic bone disease. Blossom of Citrus aurantium L. var. amara Engl. (CAVA...