HRT

Teriparatide reduces spinal neuroinflammatory phenotypes in ovariectomized rats revealed by an artificial intelligence-driven glial cell morphometry of bright-field tissue sections.

Osteoporosis frequently presents with lower back pain, often accompanied by hypersensitivity, even in the absence of vertebral fractures, suggesting the involvement of central neuroinflammatory mechanisms. The activation of spinal glia has been implicated as a key driver of pain. Clinical and preclinical studies have also shown that teriparatide (TPTD), a bone anabolic drug, alleviates osteoporoti...

Artificial intelligence models for osteoporosis risk prediction in postmenopausal women with CKD: A cross-sectional analysis of NHANES 2005 to 2018.

Artificial intelligence (AI) can transform osteoporosis (OP) screening, but its application in high-risk, complex populations like postmenopausal women with chronic kidney disease remains limited. We sought to develop and interpret an explainable AI model specifically for identifying low bone mass (LBM) or OP in this vulnerable group. Using data from the National Health and Nutrition Examination S...

Advancing diagnostic equity through artificial intelligence chest radiograph screening for osteoporosis in Asian populations.

Early identification of abnormal bone mineral density (BMD) through opportunistic screening is critical for preventing osteoporotic fractures. We vali...

The ATF5-GPER1 axis drives female protection in hepatocellular carcinoma through dual tumor-suppressive and immune-modulatory mechanisms.

Hepatocellular carcinoma (HCC) exhibits marked sexual dimorphism, with females demonstrating superior survival, yet the underlying molecular mechanism...

Identification and validation of NETs-associated biomarkers in osteoporosis with diabetes.

Osteoporosis and diabetes represent major global public health challenges. Neutrophil extracellular traps (NETs) serve as key components of the innate...

A metabolomics-driven machine learning model for osteoporosis risk prediction.

Osteoporosis, marked by decreased bone mineral density (BMD), poses a major public health concern by increasing fracture risk, lowering quality of lif...

Use of artificial intelligence and radiomics for diagnosis and prediction of osteoporotic fractures: a systematic review.

AIM: Osteoporosis (OP) is a prevalent metabolic bone disease causing millions of fractures annually, leading to significant healthcare and economic bu...

Molecular-level understanding of the aging bone and regeneration mechanisms using computational methods.

Bone degeneration diseases, such as osteoporosis, are skeletal disorders characterized by diminished bone mass and increased susceptibility to fractur...

Clinical implementation of AI for vertebral fracture detection in CT aligned with fracture liaison services: high prevalence of undiagnosed vertebral fractures.

UNLABELLED: We assessed feasibility and effectiveness of AI-based VF screening in CT, integrated with a local FLS. The system identified VFs in 14% of...

The application of machine learning-assisted serum SERS technology in the early screening and prognosis evaluation of osteoporosis.

Early detection, early intervention, early treatment, and timely prognostic monitoring of osteoporosis are crucial for improving patients' quality of ...

Prediction of surgery type for uterine fibroids using machine learning algorithms and hormone values.

This study aimed to develop and externally validate machine learning (ML)-based models to characterize surgical classification patterns between hyster...

Machine learning model integrating oral microbiota and clinical features for predicting osteoporosis and bone loss in high-altitude populations.

Women's reproductive factors predict local brain aging profiles mapped using deep neural networks.

Deep neural networks (DNNs) trained on magnetic resonance images can estimate global brain age (GBA), which reflects women's neurological disease risk...

Bone Mineral Density of Spine Patients with CT Hounsfield Units and AI Segmentation: A Contemporary Review.

It is widely accepted that bone mineral density affects outcomes for spinal arthrodesis surgeries. Traditional techniques such as dual-energy X-ray ab...

Integration of multi-omics and machine learning to reveal the anti-osteoporosis effects of Hederagenin by inhibiting lipid peroxidation via the GPX4/p-STAT1/PTGS2 axis.

Osteoporosis (OP) is a multifactorial disease, leading to abnormal bone remodeling, requiring targeted therapeutic interventions. This study investiga...

Deep Learning-Based Prediction of Trabecular Bone Mineral Density From Lumbar CT: A Superior Alternative to DEXA in Hyperostosis.

Study DesignRetrospective Cohort Study.ObjectivesThis study explores using deep learning to predict lumbar spine bone mineral density (BMD) from CT im...

Diagnostic accuracy of deep learning vs. human raters for detecting osteoporotic vertebral compression fractures in routine CT scans.

OBJECTIVES: Vertebral fractures are severe complications of osteoporosis but are frequently missed on computed tomography (CT). Differentiating true f...

Two -stage contrastive learning framework for vertebral compression fracture screening in frontal chest X-ray.

Vertebral Compression Fractures (VCFs) are early signs of osteoporosis and the most common type of osteoporotic fracture. In clinical practice, the pi...

Immunotherapy in Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Medicine-Overcoming Resistance and Optimizing Clinical Outcomes.

Triple-negative breast cancer (TNBC) is the most violent type of breast cancer, in which estrogen receptors (ER), progesterone receptors (PR), and hum...

Skin deep: dermatologic challenges in PCOS through the female lifespan.

INTRODUCTION: Polycystic ovary syndrome (PCOS) is a lifelong endocrine-metabolic condition with prominent dermatologic manifestations such as hirsutis...